Juvenile Idiopathic Arthritis-associated Uveitis at an Italian Tertiary Referral Center: Clinical Features and Complications

Paroli, Maria Pia; Abbouda, Alessandro; Restivo, Lucia; Sapìa, Alfredo; Abicca, Irene; Pezzi, Paola Pivetti

doi:10.3109/09273948.2013.855798

Cited by 28 publications

(28 citation statements)

References 29 publications

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“…Chronic keratic precipitates and posterior synechiae were found in 38.09% and 42.85%, respectively, of cases. In addition, posterior synechiae were found in 42.85% of cases, which is in agreement with the data reported by others (29% -52% [19,25,27]). The frequency of complications of uveitis is presented in Figure 1.…”

Section: Resultssupporting

confidence: 92%

Features of the course and treatment of JIA-associated uveitis

Panchenko¹,

Shevchenko²,

Demianenko³

et al. 2019

Oftalmol Zh

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To investigate the features of the clinical course of and the state of eye care for patients with juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U). Materials and Methods: We analyzed the results of monitoring 121 patients aged 7 to 18 years with JIA. Twenty one (17.35%) of these had uveitis. Results: In 17 (80.95%) of the examined JIA-U patients, JIA onset age was younger than 6 years, and mean JIA onset age was significantly younger than in JIA patients without uveitis (2.89±0.26 years vs 6.43±0.4 years, р<0.05). Most (85.7%) JIA-U patients were asymptomatic. Chronic keratic precipitates and posterior synechiae were found in 38.09% and 42.85%, respectively, of cases. Uveal cataract was the most common complication (57.14%), followed by corneal degeneration (33.33%), macular edema (28.57%), ocular hypertension/ secondary glaucoma (19.05%), optic nerve edema (14.28%), hypotony (14.28%), vitreous fibrosis (9.52%), and retinal detachment (4.76%). The frequency of administration of biologics was 57.14%. The mean time from disease onset to administration of biologics in our JIA-U patients (2.67±0.79 years) was 2.5 times less than the value for JIA-U patients from all over Ukraine (6.9 years), indicating that biologics were timely administered. Conclusion: Patients with the condition are commonly asymptomatic and have frequent ocular complications, with uveal cataract being the most common, followed by corneal degeneration and macular edema.

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Section: Resultssupporting

confidence: 92%

Features of the course and treatment of JIA-associated uveitis

Panchenko¹,

Shevchenko²,

Demianenko³

et al. 2019

Oftalmol Zh

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“…13 Calcific band keratopathy, a chronic degenerative condition characterized by the deposition of grayish opacities in the superficial layers of the cornea, most frequently in the interpalpebral zone, may also be a feature of systemic inflammatory conditions, especially juvenile idiopathic arthritis. 29,30 A recent retrospective cohort study showed that band keratopathy is one of the most common ocular complications in patients with juvenile idiopathic arthritis together with cataract and posterior synechia. 30 Accumulation of calcium can cause irritation, photophobia, recurrent corneal erosions, and depending on the extension, can result in significant glare and decreased vision.…”

Section: Corneal Manifestationsmentioning

confidence: 99%

“…29,30 A recent retrospective cohort study showed that band keratopathy is one of the most common ocular complications in patients with juvenile idiopathic arthritis together with cataract and posterior synechia. 30 Accumulation of calcium can cause irritation, photophobia, recurrent corneal erosions, and depending on the extension, can result in significant glare and decreased vision. Various modalities have been used in the treatment of band keratopathy, the most popular being, mechanical debridement, ethylenediaminetetraacetic acid chelation, and phototherapeutic keratectomy.…”

Section: Corneal Manifestationsmentioning

confidence: 99%

Corneal Involvement in Systemic Inflammatory Diseases

Gomes

Santhiago

Jorge³

et al. 2015

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Corneal involvement in patients with systemic inflammatory disorders may be sight threatening, and it may be associated with a life-threatening disease. Significant systemic inflammatory diseases in this context are autoimmune connective tissue diseases, systemic autoimmune dermatological disorders, and autoimmune diseases of the lacrimal system. Keratoconjunctivitis sicca is usually the most common ocular finding in these patients. Peripheral ulcerative keratitis is a rare condition usually associated with increased ocular morbidity and also mortality, as it might act as an indicator of a more widespread vasculitis. Corneal biomechanical properties may also be altered in connective tissue diseases. Although recent studies suggest that the risk for corneal complications after ocular surgery in patients with quiescent autoimmune disease is minimal, caution is still recommended, as the knowledge about the corneal wound-healing process and the corneal biomechanical properties in these patients is not yet fully understood. This article reviews corneal abnormalities and characteristics in the setting of systemic inflammatory diseases.

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“…Die Augenkomplikationen führen zu einer dauerhaften, erheblichen Sehverschlechterung (Visus <0,5) bei 10-20 % der Patienten. Blindheit (20/200 oder schlechter) in mindestens einem Auge tritt bei 5-10 % der Uveitispatienten auf (28,29). Die meisten Komplikationen und eine Visusreduktion treten innerhalb der ersten 7 Jahre auf, aber ihre Prävalenz steigt mit anhaltender Dauer der Erkrankung weiter an.…”

Section: Augenfolgeerscheinungenunclassified

Was wird aus den JIA-Patienten im erwachsenen Alter?

Minden¹,

Peitz²

2015

Kinder- und Jugendmedizin

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ZusammenfassungDie juvenile idiopathische Arthritis (JIA) gilt mittlerweile als gut zu behandelnde Erkrankung. Allerdings hat ein doch beträchtlicher Anteil der JIA-Patienten als Erwachsene residuale Schäden, teils weiterbestehende Krankheitsaktivität, teils vielfältige Einschränkungen in ganz unterschiedlichen Bereichen des täglichen Lebens. In diesem Artikel zeigen wir einen kurzen Überblick zum Thema Langzeit-Outcome und Prognose der JIA.

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Juvenile Idiopathic Arthritis-associated Uveitis at an Italian Tertiary Referral Center: Clinical Features and Complications

Abstract: Loss of vision and ocular complications still occur among children with JIA-related uveitis. Prompt diagnosis and a strict follow up associated to immunosuppressive therapy may decrease the poor visual outcome.

Cited by 28 publications

References 29 publications

Features of the course and treatment of JIA-associated uveitis

Features of the course and treatment of JIA-associated uveitis

Corneal Involvement in Systemic Inflammatory Diseases

Was wird aus den JIA-Patienten im erwachsenen Alter?

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