Juvenile Mandibular Chronic Osteomyelitis: Role of Surgical Debridement and Antibiotics

Renapurkar, Shravan; Pasternack, Mark S.; Nielsen, P. Gamborg; Kaban, Leonard B.

doi:10.1016/j.joms.2015.06.067

Cited by 6 publications

(11 citation statements)

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“…Topazian et al recommend continuation of treatment for 2‐4 months after resolution of symptoms, whereas Bartkowski et al used intravenous therapy for a period of 10‐24 days . Oral b‐lactam therapy is generally given at doses of approximately 75‐100 mg/kg daily for children weighing <40 kg and 2‐3 g daily for children weighing more than 40 kg . Steroids including prednisolone are given in doses of 40 and 60 mg in acute stages.…”

Section: Discussionmentioning

confidence: 99%

Chronic recurrent osteomyelitis: A surgeon's enigma

Kudva

Kamath

Dhara

et al. 2019

J Oral Pathology Medicine

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Background Chronic recurrent forms of osteomyelitis of the mandible with their morbid clinical course have long been considered a challenge to maxillofacial surgeons in terms of both diagnosis and treatment. Various classifications and treatments have been established through the ages to define and manage the inflammatory symptoms occurring in adults and children. This paper discusses two such entities occurring in an adult and a child, highlighting the diagnostic and treatment challenges of recurrent osteomyelitis. Methods A thorough workup which included clinical, radiographic, blood investigations was done, followed by administration of antibiotics and anti‐inflammatory with or without surgical debridement/adjuvant therapies. Correlation of our findings and treatment plan was done with evidence‐based literature and practice. Results Complete resolution of symptoms with radiographic evidence was achieved in both the cases. In the recurrence period, long‐term steroids, NSAIDs, antibiotics resulted in better outcomes. Conclusion The evidence‐based protocol for osteomyelitis stresses on short inpatient stays predicated on efficient literature. Thorough clinical and radiographic evaluation with aggressive medical management and surgical intervention when necessary can result in longer symptom‐free periods. Thus understanding the disease, recurrence pattern and response to therapy is essential.

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Section: Discussionmentioning

confidence: 99%

Chronic recurrent osteomyelitis: A surgeon's enigma

Kudva

Kamath

Dhara

et al. 2019

J Oral Pathology Medicine

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“…Renapurkar et al . 2016 uses Heggie's diagnosis of Juvenile Mandibular Chronic Osteomyelitis (JMCO) and hypothesises that JMCO is an infectious disease and that negative cultures might represent a failure of standard culture techniques to isolate the responsible organisms . This is based on recent studies that have used 16S ribosomal RNA sequencing to identify previously uncultured phylotypes.…”

Section: Discussionmentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis of the jaw – difficulties in diagnosis

Molyneaux

2018

Oral Surgery

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“…10-12 However, the role of these organisms is difficult to assess as they are often isolated ( with or without A israelii ) from intraoral biopsies. 1,2,4 Also, the fact that most patients experience exacerbations while receiving antibiotics suggests that antibiotic treatment has minimal effect on the course of the disorder. 1-3,6,8,13 The effectiveness of surgical procedures (ie, debridement, curettage, decortication, and resection), often performed in conjunction with antibiotic therapy on patients who continue to have frequent exacerbations, is also difficult to assess.…”

Section: Discussionmentioning

confidence: 99%

“…The absence of an explanation for causation and the use of various descriptive diagnostic terms (diffuse sclerosing osteomyelitis, ossifying periostitis, primary chronic osteomyelitis) in the early reports caused difficulties in recognizing and comparing specific clinical patterns. 1-4…”

Section: Introductionmentioning

confidence: 99%