Juvenile nasopharyngeal angiofibroma: current treatment modalities and future considerations

Hodges, John M.; McDevitt, Annette S.; Ali, Ahmed; Sebelik, Merry

doi:10.1007/s12070-010-0073-x

Cited by 18 publications

(22 citation statements)

References 39 publications

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“…While different staging systems have been proposed for JAF, a comparable classification for ENAs does not exist. One to 2 years pass before diagnosing JAF, in contrast to only several months in ENA .…”

Section: Discussionmentioning

confidence: 99%

“…Management of JAF has become more refined by high‐resolution CT/MRI, angio‐MRI, preoperative embolisation, improved anaesthesia and an increased familiarity with skull base surgical approaches including endoscopic surgical techniques . Hormonal therapy, irradiation and systemic chemotherapy have been applied in selected cases of JAF, but surgery remains the therapy of choice.…”

Section: Discussionmentioning

confidence: 99%

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Extranasopharyngeal angiofibroma revisited

Windfuhr

Vent

2017

Clinical Otolaryngology

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Background Angiofibromas in the head and neck region usually arise in the nasopharynx, but may also occur elsewhere. This study aims at evaluating the incidence and clinical features of extranasopharyngeal angiofibroma (ENA). Material and Methods Systematic review of the literature (Medline® and Google™) up to 31 December 2015. Results 174 cases of ENA were retrieved from a total of 170 publications. In contrast to former publications and previous understanding, the nasal septum was by far the most common site of the disease. Four patients had a congenital lesion, the oldest patient was 87 years old (mean: 28.7 years; median: 23 years). Male gender was predominantly affected, but the sex ratio was more balanced (2.13:1) than in previous reports in the literature until 12/2015. The majority of patients presented with nasal obstruction, either in combination with epistaxis (25.8%) or other symptoms (12.6%). Symptoms had developed within 13.1 months on average (median: 4 months). Brisk bleeding resulted in 11 of 43 biopsy procedures. Surgical resection as first‐line therapy was performed in 170 patients. A tumour regrowth within 12 months was registered in four patients. Conclusion The increasing awareness of ENA and the willingness to publish case reports—not only in Medline‐listed journals—resulted in a significant increase of published case reports lately. Although extremely rare, ENAs have to be taken into account in the differential diagnosis of unclear masses, particularly in adult patients presenting with a rapidly developing nasal obstruction resulting from a nasal septum tumour. Female gender or normal vascularity does not exclude the diagnosis. Transnasal resection is sufficient in most cases, and recurrences are rare. Pathologists as well as clinicians should consider ENA in their differential diagnosis of any mass of the upper airway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extranasopharyngeal angiofibroma revisited

Windfuhr

Vent

2017

Clinical Otolaryngology

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“…Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular and histologically benign tumour and the most common benign tumour of the nasopharynx. 1 However, it is a rare tumour accounting for 0.05% to 0.5% of all head and neck tumours. 2 They appear almost exclusively in males between the ages of 10 and 20.…”

Section: Introductionmentioning

confidence: 99%

Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ENT department of IPO‐PORTO

Sousa

Patrão

Pereira

et al. 2019

Clinical Otolaryngology

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“…In the development of the lesion, the involvement of pituitary gland-gonad axis is suggested as causative factor [8]. Latest opinions suggest JNA as developmental defect which is affecting the embryonic vascular network surrounding the sphenoid bone [9]. JNA is a highly vascular tumor.…”

Section: Discussionmentioning

confidence: 99%

Complications of Midface Swing for Management of Juvenile Nasopharyngeal Angiofibroma

Chowdhury

Rajkumar

Deshmukh

2016

J. Maxillofac. Oral Surg.

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Introduction Access osteotomies provide direct exposure to inaccessible areas of the deep part of craniofacial skeleton for treating pathologies involving vital structures. The use of maxillary swing approach for gaining wide access to the nasopharynx, infratemporal fossa, parapharyngeal space, middle fossa of skull base. Though the maxillary swing requires transfacial incision for wide exposure but with careful handling the scar is minimum and this approach can be used in young people. Materials and Methods Surgical resection is carried out following preoperative embolization of the involved feeder vessels. Total 16 cases were considered for this study. Results This article highlights cases successfully treated in our institution, the mention of complications associated with the cases along with management. Conclusion Maxillary swing is a good approach for getting access to the deep pathologies like JNA.

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Juvenile nasopharyngeal angiofibroma: current treatment modalities and future considerations

Cited by 18 publications

References 39 publications

Extranasopharyngeal angiofibroma revisited

Extranasopharyngeal angiofibroma revisited

Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ENT department of IPO‐PORTO

Complications of Midface Swing for Management of Juvenile Nasopharyngeal Angiofibroma

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