Juvenile Nasopharyngeal Angiofibroma in a Female: Report of a Case

Osborn, D. A.; Sokolovski, A.

doi:10.1001/archotol.1965.00760010631014

Cited by 44 publications

(13 citation statements)

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“…[2][3][4] Rare cases have been reported in men over 25 years old and in adolescent girls. [5][6][7][8][9] JNA emerges in the posterolateral wall of the nasal cavity posterior to the pterygopalatine ganglion and may extend through adjacent structures by pressure erosion through bone. 10 These tumors are nonencapsulated entities composed of a proliferating and irregular vascular component within a fibrous stroma consisting predominantly of fibroblasts.…”

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confidence: 99%

Genetic alterations in juvenile nasopharyngeal angiofibromas

2008

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Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors. Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension. The gender selectivity of JNA and the relatively young age at diagnosis suggest hormone-dependent development. Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial. Recent studies have attempted to further delineate the pathogenesis of JNA through analysis of genetic and molecular changes. Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor. In this review, we discuss published studies addressing the possible molecular pathways that might be involved in the development of JNA.

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confidence: 99%

Genetic alterations in juvenile nasopharyngeal angiofibromas

2008

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“…Further, the association of NAF with familial adenomatous polyposis, in which the prevalence of NAF is 25 times more common than in age-matched controls [15], has not been confirmed in this case series. We consider that NAF occurs exclusively in males, and previous reports in females probably do not represent this tumor, or at least, documentation is not convincing [16][17][18][19]. In 1965, Apostol and Frazell [20] reported 40 cases of NAF in male patients, and suggested that if this diagnosis is confirmed in a female, sex chromosome studies must be performed, to investigate for androgen insensitivity syndrome (formerly testicular feminization) of a phenotypic female but genetic male [18,20].…”

Section: Discussionmentioning

confidence: 86%

Nasopharyngeal Angiofibroma: A Clinical, Histopathological and Immunohistochemical Study of 42 Cases with Emphasis on Stromal Features

Sánchez‐Romero

Carlos²,

Molina³

et al. 2017

Head and Neck Pathol

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“…The histology, the site of the tumour and the history of the profuse bleeding are all characteristic of this tumour with the exception of the patient's age (49 years). But for a few exceptions -Osborn (1959); Osborn and Sokolovski (1965);Rominger and Santore (1968) -juvenile angiofibroma has been described to occur only in young male patients up to the age of 25 years.…”

Section: Discussionmentioning

confidence: 99%