Juvenile Nasopharyngeal Angiofibroma

Abstract

Seven cases of biopsy-proved juvenile nasopharyngeal angiofibroma are presented. All patients were males. Examination under anesthesia and tomography and angiography were very rewarding in determining the full extent of tumor. Selective carotid angiography revealed a characteristic early arterial phase with reticulated vessels, and a homogeneous blush continuing into the venous phase without early draining veins. The tumor has a strong predilection for young males. Chromosomal studies and estimation of 17-ketosteroids in 4 patients were normal. None of the patients demonstrated sexual underdevelopment. All were treated by external radiotherapy with 3000 rads in 15 fractions in three weeks with good results. There were no undue side effects.

Extranasopharyngeal angiofibroma revisited

“…Although malignant transformation in angiofibroma after radiotherapy has been reported, it has been recommended for unresectable tumours, failure of complete tumour removal or for extensive intracranial extension . A local control rate of 80%‐85% in terms of symptom regression has been reported, comparable to surgical procedures . A total irradiation dose of 30‐35 Gy is recommended but may be increased to 40‐45 Gy for extensive lesions .…”

The Role of Radiation in the Treatment of Advanced Juvenile Angiofibroma

“…The results of those papers are summarized in Table II (all types of JNA treated with primary radiation) and Table III ( only advanced JNA with tumor involving the pterygomaxillary fossa, orbit, or middle cranial fossa treated with radiation), respectively. 15–23 …”

“…The results of those papers are summarized in Table II (all types of JNA treated with primary radiation) and Table III (only advanced JNA with tumor involving the pterygomaxillary fossa, orbit, or middle cranial fossa treated with radiation), respectively. [15][16][17][18][19][20][21][22][23] Although radiation has been reported to be an effective means of therapy for JNA, potential long-term complications have dissuaded some from pursuing this course of treatment. Secondary malignancies of the head and neck signify one of the most feared adverse sequelae of radiation exposure.…”

Complete resolution of stage IIIB juvenile nasopharyngeal angiofibroma with radiation therapy

“…Although radiation has been reported to be an effective measure of therapy for JNA [1,5,6,7,8,9,10,11], potential long term complications have discouraged many from pursuing this course of therapy. Thyroid carcinoma, bone and soft tissue sarcomas, basal cell carcinoma, hypopituitarism, cataract, osteoradionecrosis, optic nerve, atrophy, osteomyelitis of skull base, facial growth retardation in maturing adolescents, all have been reported by various authors [6,[10][11][12][13][14].…”