Juvenile onset inflammatory bowel disease: height and body mass index in adult life

Ferguson, Anne; Sedgwick, D M

doi:10.1136/bmj.308.6939.1259

Cited by 87 publications

(63 citation statements)

References 20 publications

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“…Only a few reports have assessed the final adult height in IBD patients with paediatric onset disease [4][5][6][7][8][9]. Prospective studies mostly included paediatric patients up to the age of 18 years [4,5], and retrospective studies carried out in adult patients either analyse patients with CD diagnosed before the age of 16 or 17 years [7,8] as a single group, patients with UC and CD as a mixed group [1,9] or report height measures collected by telephone or from passports [4]. In this study, we have separately analysed patients with either UC/IU or CD and with either prepubertal, pubertal or adult-onset disease, and we have compared measured and dated final height of patients with prepubertal disease onset with that of patients with pubertal or adult disease onset and with that of healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Early-onset Crohn’s disease is a risk factor for smaller final height

Herzog

Fournier²,

Buehr³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

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OBJECTIVES: Growth retardation is a frequent complication of paediatric inflammatory bowel disease (IBD). Only a few studies report the final height of these patients, with controversial results. We compared adult height of patients with paediatric IBD with that of patients with adultonset disease. METHODS: Height data of 675 women 19-44 years of age and 454 men 23-44 years of age obtained at inclusion in the Swiss IBD cohort study registry were grouped according to the age at diagnosis: (a) prepubertal (men13, women11 years), (b) pubertal (men 13-22, women 11-18 years) and (c) adult (men>22, women>18 years of age), and compared with each other and with healthy controls. RESULTS: Male patients with prepubertal onset of Crohn's disease (CD) had significantly lower final height (mean 172±6 cm, range 161-182) compared with men with pubertal (179±6 cm, 161-192) or adult (178±7 cm, 162-200) age at onset and the general population (178±7 cm, 142-204). Height zscores standardized against heights of the normal population were significantly lower in all patients with a prepubertal diagnosis of CD (-0.8±0.9) compared with the other patient groups (-0.1±0.8, P<0.001). Prepubertal onset of CD emerged as a risk factor for reduced final height in patients with prepubertal CD. No difference for final height was found between patients with ulcerative or unclassified IBD diagnosed at prepubertal, pubertal or adult age. CONCLUSION: Prepubertal onset of CD is a risk for lower final height, independent of the initial disease location and the necessity for surgical interventions.

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Section: Discussionmentioning

confidence: 99%

Early-onset Crohn’s disease is a risk factor for smaller final height

Herzog

Fournier²,

Buehr³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

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“…Earlier paediatric IBD populations have been described as being underweight and malnourished, with lower body mass index (BMI) than the normal distribution [67]. However, studies since the turn of the millennium have revealed that children with IBD are affected by current population trends towards weight gain; 10 % and 20-30 % of incident CD and UC patients were overweight or at risk of being overweight as per BMI [68].…”

Section: The Changing Phenotype Of Ibdmentioning

confidence: 99%

The microbiota in inflammatory bowel disease

2015

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This review explores our current understanding of the complex interaction between environmental risk factors, genetic traits and the development of inflammatory bowel disease. The primacy of environmental risk factors is illustrated by the rapid increase in the incidence of the disease worldwide. We discuss how the gut microbiota is the proximate environmental risk factor for subsequent development of inflammatory bowel disease. The evolving fields of virome and mycobiome studies will further our understanding of the full potential of the gut microbiota in disease pathogenesis. Manipulating the gut microbiota is a promising therapeutic avenue.

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“…Previous studies of the juvenile IBD population diagnosed between 1963 and 1983 and followed up in adult life showed that the CD population had significantly lower body weight than people with ulcerative colitis (UC) and significantly lower BMI than the general population, whereas all UC patients had normal BMIs [4].…”

Section: Introductionmentioning

confidence: 99%

A Brief Report of the Epidemiology of Obesity in the Inflammatory Bowel Disease Population of Tayside, Scotland

2009

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Aim: Obesity in inflammatory bowel disease (IBD), particularly Crohn’s disease (CD), has previously been considered unusual (3%). CD patients who are obese tend to have increased perianal complications and a higher level of disease activity on an annual basis. Obesity in Scotland has been documented to have increased over the last decade, and over half all men and women in Scotland are now considered to be overweight. This study aims to assess obesity prevalence in the IBD community in Tayside, Scotland. Methods: All IBD patients (n = 1,269) were considered for inclusion. Inclusion criteria required a weight measurement taken from the preceding 12 months and a height measurement within the last decade. 489 patients were included in the analysis. Results: 18% of the Tayside IBD population were obese in comparison to approximately 23% of the Scottish population on a whole. A further 38% of patients were over-weight, the same percentage as the general population. In the overweight and obese ulcerative colitis patients there were higher levels of surgery, but the converse was true in the CD group, where the normal-weight group had the highest levels of surgery. There were significantly more obese men and women with CD than with ulcerative colitis (P = 0.05). Conclusion: Obesity prevalence has increased in IBD patients. This is significant because of the known increased levels of postoperative complications, perianal disease and requirement for more aggressive medical therapy. Research needs to be done to look at the effects of obesity on the co-morbid associations of other diseases with IBD, in particular colorectal cancer, and to ascertain whether or not screening frequency should be altered depending on BMI.

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Juvenile onset inflammatory bowel disease: height and body mass index in adult life

Cited by 87 publications

References 20 publications

Early-onset Crohn’s disease is a risk factor for smaller final height

Early-onset Crohn’s disease is a risk factor for smaller final height

The microbiota in inflammatory bowel disease

A Brief Report of the Epidemiology of Obesity in the Inflammatory Bowel Disease Population of Tayside, Scotland

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