Juvenile Particulate Osteochondral Allograft for Treatment of Osteochondral Lesions of the Talus: Detection of Altered Repair Tissue Biochemical Composition Using 7 Tesla MRI and T2 Mapping

Vira, Shaleen; Ramme, Austin J.; Chapman, Cary B; Xia, Ding; Regatte, Ravinder R.; Chang, Gregory

doi:10.1053/j.jfas.2016.09.012

Cited by 6 publications

(13 citation statements)

References 29 publications

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“…After full-text screening, 51 studies were included. 2 , 11 - 60 There was an overall consensus in all cases of article selection between the first 2 authors.…”

Section: Resultsmentioning

confidence: 99%

“…Due to this underreporting, we were unable to compare individual location sizes within the 9-zone grid with the Student t test. 13 , 16 , 21 , 35 , 36 , 43 , 45 , 52 , 58 , 72 This can be considered a limitation of the review. Future research must focus on including the individual patient OLT-size, in order for a powerful statistical analysis on OLT-size per location to be possible.…”

Section: Discussionmentioning

confidence: 99%

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Location Distribution of 2,087 Osteochondral Lesions of the Talus

et al. 2020

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Objective The primary aim of this study was to evaluate the exact location distribution in patients with osteochondral lesions of the talus (OLTs) using a 9-grid scheme. The secondary aim is to match lesion location to lesion size, arthroscopic or open operation, and trauma occurrence. Methods A systematic review was performed in the databases PubMed, EMBASE, and Cochrane. Search terms consisted of “talus” and “osteochondral lesion.” Two independent reviewers evaluated search results and conducted the quality assessment using the Methodological Index for Non-Randomized Studies (MINORS). Primary outcome measure was OLT location in the 9 zone-grid. Secondary outcome measures were OLT size in 9-zones, preoperative radiological modality use, demographic lesion size variables as well as open or arthroscopic treatment. Results Fifty-one articles with 2,087 OLTs were included. Heterogeneity concerning methodological nature was observed and methodological quality was low. The posteromedial (28%) and centromedial (31%) zones combined as one location was the location with the highest incidence of OLTs with a rate of 59%. Individual OLT size was reported for only 153 lesions (7%). Preoperative combination of X-ray and magnetic resonance imaging (MRI), and/or computed tomography (CT) was reported in 20 studies (43%). Trauma was reported in 78% of patients. Furthermore, 67% was treated arthroscopically and 76% received primary OLT treatment. Conclusion The majority of OLTs are located in the posteromedial and centromedial zone, while the largest OLTs were reported in the centrocentral zone. Further research is required to identify the prognostic impact of location occurrence on the outcomes following OLT treatment.

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“…After full-text screening, 51 studies were included. 2 , 11 - 60 There was an overall consensus in all cases of article selection between the first 2 authors.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Location Distribution of 2,087 Osteochondral Lesions of the Talus

et al. 2020

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“…87 Interestingly, similar results were shown for the ankle in a 7 T MRI study that quantified and compared T2 values of native tibiotalar cartilage and cartilage repair tissue in patients treated with a juvenile particulate allograft for osteochondral lesions of the talus. 88 Lazik-Palm et al 21 focused on the morphology and quantitative analysis of cartilage in patients undergoing hip cartilage transplantation. They investigated 9 patients with a history of autologous acetabular cartilage transplantation with 7 T and 3 T MRI and compared the images regarding image quality, assessability of cartilage structures, and CNR among articular cartilage, joint fluid, and subchondral bone.…”

Section: Articular Cartilagementioning

confidence: 99%

“…Interestingly, similar results were shown for the ankle in a 7 T MRI study that quantified and compared T2 values of native tibiotalar cartilage and cartilage repair tissue in patients treated with a juvenile particulate allograft for osteochondral lesions of the talus. 88 …”

Section: Clinical Implementationmentioning

confidence: 99%

7 T Musculoskeletal MRI

2022

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This review summarizes the current state-of-the-art of musculoskeletal 7 T magnetic resonance imaging (MRI), the associated technological challenges, and gives an overview of current and future clinical applications of 1H-based 7 T MRI. The higher signal-to-noise ratio at 7 T is predominantly used for increased spatial resolution and thus the visualization of anatomical details or subtle lesions rather than to accelerate the sequences. For musculoskeletal MRI, turbo spin echo pulse sequences are particularly useful, but with altered relaxation times, B1 inhomogeneity, and increased artifacts at 7 T; specific absorption rate limitation issues quickly arise for turbo spin echo pulse sequences. The development of dedicated pulse sequence techniques in the last 2 decades and the increasing availability of specialized coils now facilitate several clinical musculoskeletal applications. 7 T MRI is performed in vivo in a wide range of applications for the knee joint and other anatomical areas, such as ultra-high-resolution nerve imaging or bone trabecular microarchitecture imaging. So far, however, it has not been shown systematically whether the higher field strength compared with the established 3 T MRI systems translates into clinical advantages, such as an early-stage identification of tissue damage allowing for preventive therapy or an influence on treatment decisions and patient outcome. At the moment, results tend to suggest that 7 T MRI will be reserved for answering specific, targeted musculoskeletal questions rather than for a broad application, as is the case for 3 T MRI. Future data regarding the implementation of clinical use cases are expected to clarify if 7 T musculoskeletal MRI applications with higher diagnostic accuracy result in patient benefits compared with MRI at lower field strengths.

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“…T2 relaxation time mapping has been studied in rheumatoid arthritis ( 9 ), osteoarthritis ( 10 ), postoperative knee ( 11 ) and ankle repair ( 12 ), juvenile osteochondrosis ( 13 ), and the healthy pediatric knee ( 14 ). Furthermore, in a longitudinal study of children with early juvenile idiopathic arthritis, despite improved clinical assessments, T2 values increased from the 3‐ to 24‐month assessment, suggesting progressive microstructural changes that were not detectable with standard imaging ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of T2 Mapping of the Sacroiliac Joints in Healthy Control Subjects and Children and Young Adults with Sacroiliitis

Francavilla

Serai

Brandon

et al. 2021

ACR Open Rheumatology

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Objective. To assess the feasibility of T2 mapping for evaluating pediatric SIJ cartilage at 3 Tesla (T) magnetic resonance imaging (MRI).Methods. Healthy control subjects and adolescents with sacroiliitis underwent a 3T MRI dedicated pelvic protocol that included a T2 mapping sequence consisting of multislice, multiecho acquisition. Healthy control subjects were prospectively recruited from our primary care practices as part of a larger imaging study, whereas adolescents with sacroiliitis were recruited specifically for this study. Regions of interest (ROIs) were hand-drawn by a senior pediatric radiologist twice and a radiology fellow twice to calibrate and test reliability using the intraclass correlation coefficient (ICC). T2 relaxation time between control subjects and cases was compared using univariate linear regression. We tested the association of T2 relaxation time in adolescents with sacroiliitis with patient-reported outcomes and the Spondyloarthritis Research Consortium of Canada sacroiliac joint (SIJ) inflammation and structural scores using Pearson correlation coefficients.Results. Fourteen subjects were evaluable (six control subjects: median age 13.7 years [interquartile range (IQR): 12.2-15.5], 67% male patients; eight cases: median age 17.4 years [IQR: 12.5-20], 88% male patients]. Acquisition time for T2 mapping sequences was approximately 6 minutes, and segmenting the ROI for each SIJ took approximately 3 minutes. The intrarater and inter-rater ICCs were 0.67 and 0.46, respectively, indicating good to fair reliability. There was a trend, albeit statistically insignificant, in longer median T2 relaxation time in cases (43.04 ms; IQR: 41.25-49.76 ms) versus healthy control subjects (40.0 ms; IQR: 38.9-48.6 ms). Although not statistically significant, cases with longer T2 relaxation time tended to occur with poorer patient-reported outcomes. Correlations with the SIJ inflammation and structural lesion scores were weak.Conclusion. T2 mapping of the SIJ cartilage in children was feasible and reliable. Larger controlled and longitudinal assessments are needed to assess the validity and utility of these measurements for routine clinical practice and trials.

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Juvenile Particulate Osteochondral Allograft for Treatment of Osteochondral Lesions of the Talus: Detection of Altered Repair Tissue Biochemical Composition Using 7 Tesla MRI and T2 Mapping

Cited by 6 publications

References 29 publications

Location Distribution of 2,087 Osteochondral Lesions of the Talus

Location Distribution of 2,087 Osteochondral Lesions of the Talus

7 T Musculoskeletal MRI

Feasibility of T2 Mapping of the Sacroiliac Joints in Healthy Control Subjects and Children and Young Adults with Sacroiliitis

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