Juvenile primary fibromyalgia syndrome: A Review- Treatment and Prognosis

Coles, Maya Levy; Uziel, Yosef

doi:10.1186/s12969-021-00529-x

Cited by 11 publications

(14 citation statements)

References 99 publications

(112 reference statements)

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“…Additionally, although most studies have focused on investigating FM in adults, its occurrence has also been reported in children and adolescents. 16,17 Therefore, this study contributes to the understanding of this pathology in juvenile individuals, because we used prepubertal animals.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of this study was to better understand the regulation of muscle mass in a non‐inflammatory hyperalgesia model and the potential contribution of glucocorticoids in controlling protein metabolism in skeletal muscles, as well as nociception in female rats subjected to the FM model. Additionally, although most studies have focused on investigating FM in adults, its occurrence has also been reported in children and adolescents 16,17 . Therefore, this study contributes to the understanding of this pathology in juvenile individuals, because we used prepubertal animals.…”

Section: Discussionmentioning

confidence: 99%

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Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia

Costa,

da Silva,

da Cruz‐Filho

et al. 2024

Clin Exp Pharma Physio

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Although it is well established that fibromyalgia (FM) syndrome is characterized by chronic diffuse musculoskeletal hyperalgesia, very little is known about the effect of this pathology on muscle tissue plasticity. Therefore, the present study aimed to characterize the putative alterations in skeletal muscle mass in female rats subjected to a FM model by inducing chronic diffuse hyperalgesia (CDH) through double injections of acidic saline (pH 4.0) into the left gastrocnemius muscle at 5‐day intervals. To determine protein turnover, the total proteolysis, proteolytic system activities and protein synthesis were evaluated in oxidative soleus muscles of pH 7.2 (control) and pH 4.0 groups at 7 days after CDH induction. All animals underwent behavioural analyses of mechanical hyperalgesia, strength and motor performance. Our results demonstrated that, in addition to hyperalgesia, rats injected with acidic saline exhibited skeletal muscle loss, as evidenced by a decrease in the soleus fibre cross‐sectional area. This muscle loss was associated with increased proteasomal proteolysis and expression of the atrophy‐related gene (muscle RING‐finger protein‐1), as well as reduced protein synthesis and decreased protein kinase B/S6 pathway activity. Although the plasma corticosterone concentration did not differ between the control and pH 4.0 groups, the removal of the adrenal glands attenuated hyperalgesia, but it did not prevent the increase in muscle protein loss in acidic saline‐injected animals. The data suggests that the stress‐related hypothalamic–pituitary–adrenal axis is involved in the development of hyperalgesia, but is not responsible for muscle atrophy observed in the FM model induced by intramuscular administration of acidic saline. Although the mechanisms involved in the attenuation of hyperalgesia in rats injected with acidic saline and subjected to adrenalectomy still need to be elucidated, the results found in this study suggest that glucocorticoids may not represent an effective therapeutic approach to alleviate FM symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia

Costa,

da Silva,

da Cruz‐Filho

et al. 2024

Clin Exp Pharma Physio

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“…Previously referred to as 'central pain,' the symptom hallmarks include diffuse hyperalgesia (increased pain to normally pain stimuli) or allodynia (pain to normally nonpainful stimuli). CNS-derived symptoms, including fatigue, nonrestorative sleep, cognitive dysfunction, memory, and mood disturbance, are common [7][8][9].…”

Section: Fibromyalgia and Nociplastic Painmentioning

confidence: 99%

Fibromyalgia and centralized pain in the rheumatoid arthritis patient

Minhas

Murphy

Clauw

2023

Current Opinion in Rheumatology

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Purpose of reviewIndividuals with rheumatoid arthritis (RA) have traditionally been characterized as having nociceptive pain, leading to the assumption that effective immunosuppression should be enough to provide effective pain management. However, despite therapeutic advancements providing excellent control of inflammation, patients continue to have significant pain and fatigue. The presence of concurrent fibromyalgia, driven by augmented central nervous system processing and largely unresponsive to peripheral therapies, may contribute to this pain persistence. This review provides updates on fibromyalgia and RA as relevant for the clinician. Recent findingsPatients with RA have high levels of concomitant fibromyalgia and nociplastic pain. The presence of fibromyalgia can lead to higher scores on disease measures, erroneously indicating that worse disease is presently leading to the increased use of immunosuppressives and opioids. Disease scores that provide a comparison between patient-reported and provider-reported and clinical factors may be helpful to indicate centralized pain. IL-6 and Janus kinase inhibitors, in addition to targeting peripheral inflammation, may provide pain relief by acting on peripheral and central pain pathways. SummaryCentral pain mechanisms that may be contributing to pain in RA are common and should be distinguished from pain directly arising from peripheral inflammation.

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“…In general the onset of JFS is recorded during early adolescence, younger children are also identified [4]. The mean age of diagnosis is 14.5 14.5 years, although the range is 5 to 18 years overall [5]. The average age of diagnosis is 14.5 14.5 years, although the range is from 5 to 18 years.…”

Section: Introductionmentioning

confidence: 98%

Non-Pharmacological Treatments in Juvenile Fibromyalgia. Systematic Review of Clinical Trials

Jiménez¹

2022

JCRP

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Fibromyalgia is a chronic, debilitating, non-inflammatory musculoskeletal pain syndrome. In 1992, fibromyalgia was recognised by the World Health Organisation as a debilitating disease [1]. It is characterised by constant widespread pain, especially due to tender or trigger points, paraesthesia, sleep disturbances, fatigue, irritable bowel, burning during urination, headache, memory loss, difficulty concentrating and mood disorders [1,2]. It is usually diagnosed in adolescence. It can occur in school-aged children, with headache occurring in 68% of subjects [3].

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Juvenile primary fibromyalgia syndrome: A Review- Treatment and Prognosis

Cited by 11 publications

References 99 publications

Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia

Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia

Fibromyalgia and centralized pain in the rheumatoid arthritis patient

Non-Pharmacological Treatments in Juvenile Fibromyalgia. Systematic Review of Clinical Trials

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