Juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of mandible

Deshingkar, SA; Barpande, SR; Bhavthankar, Jyoti D

doi:10.1016/j.sjdr.2013.12.002

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The prognosis of PsJOF is good since malignant transformations have not been reported. 8 The present case was followed- up for a duration of 3 years with no recurrence.…”

Section: Discussionmentioning

confidence: 79%

“… 12 , 13 Massive aggressive maxillary JOF are frequently found to be associated with secondary ABC. 8 The origin of secondary ABC is probably attributed to trauma or to a local vascular abnormality in a pre-existing bone lesion. 4 , 5 It is proposed that there is an initial focal myxoid change in the stroma of JOF followed by hemorrhage and amassing of osteoclastic giant cells which leads to gradual expansion and formation of a cyst.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Juvenile Psammomatoid Ossifying Fibroma with Secondary Aneurysmal Bone Cyst of the Maxilla: A Case Report and Review of Literature

Sarode

Ingale³

et al. 2018

Clinics and Practice

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Juvenile ossifying fibroma is a benign fibro-osseous lesion commonly affecting the extra-gnathic craniofacial skeleton of the young individuals. The psammomatoid and trabecular variants are its two histopathological subtypes having distinctive clinico-pathological characteristics. Secondary aneurysmal bone cysts are frequently reported to arise in the pre-existing fibro-osseous lesions but rarely reported in the psammmomatoid variant of the juvenile ossifying fibroma. Such hybrid lesions, especially massive in size, tend to exhibit a greater aggressive growth potential and higher recurrence rate and mandate complete surgical removal of the lesion along with a long-term follow-up. The objective of this case report was to present a rare incident of recurrent psammomatoid ossifying fibroma associated with a secondary aneurysmal bone cyst in the maxillary jaw bone of a young patient and review the similar published reports in the English literature.

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“…The prognosis of PsJOF is good since malignant transformations have not been reported. 8 The present case was followed- up for a duration of 3 years with no recurrence.…”

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Recurrent Juvenile Psammomatoid Ossifying Fibroma with Secondary Aneurysmal Bone Cyst of the Maxilla: A Case Report and Review of Literature

Sarode

Ingale³

et al. 2018

Clinics and Practice

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“…The radiographic presentation of the case reports was analyzed based on OPG and CT scan findings. A multilocular shape was found in 14% of cases in the reports of Deshingkar et al (2014). In the remaining cases (86%), unilocular lesions were reported.…”

Section: Analysis Of Srmentioning

confidence: 94%

Juvenile psammomatoid ossifying fibroma of the maxilla and mandible: A systematic review of published case reports

Chandini

Saranya

Mohideen

et al. 2022

Clinical & Exp Dental Res

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Objective: The aim of this study is to evaluate recent evidence-based data that summarize the clinicopathological findings and treatment along with follow-up measures taken in terms of published cases of Juvenile psammomatoid ossifying fibroma (JPOF) of the maxilla and mandible by a systematic review. Materials and Methods:The databases searched were PubMed, MEDLINE, Scopus, Google scholar, and Cross references. Only those case reports of JPOFs published in the English language from 2000 to 2022 were considered. All cases included confirmed JPOF lesions histopathologically. The SR-included details like clinical and radiographic data, follow-up details such as recurrence, and the presence of any adverse outcome. Results:The database search produced 595 articles from 2000 to 2022, among which 22 case reports were included in the systematic review. The mean age of JPOF occurrence in patients was 18 ± 16 years. A male predilection was noted among patients younger than 14 years of age, whereas a female predilection was noted in patients older than 14 years of age. Frequent involvement of the mandible (56%) compared to the maxilla (44%) was reported. The posterior mandible was the most commonly affected site involving numerous adjacent structures. The expansile nature of the JPOF displayed 57% buccolingual expansion, 50% downward displacement or erosion of the lower border of the mandible and 81% of involvement of the maxillary antrum/pterygoid plate/orbital floor. Among the 20 cases reported, the treatment provided included surgical excision in 45% of the patients, jaw resection in 35% of the patients, and enucleation and curettage in 18% of the patients. Follow-up details were provided in 80% of the reports that showed recurrence. Conclusions:The diagnosis of JPOF requires correlation of the clinical and radiographic features with key histopathological features. Although long-term

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First presentation of a frameshift mutation in the SETD2 gene of a juvenile psammomatoid ossifying fibroma (JPOF) associated with an aneurysmal bone cyst

et al. 2021

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Background The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour. Case presentation A 21-year-old man presented with a hard, expanded mandibular cortex. Computed tomography revealed multilocular radiopacity in the mandible; this was reconstructed via segmental mandibulectomy using a vascularised iliac crest flap. Based on the clinical and histological findings, we diagnosed JPOF associated with an aneurysmal bone cyst. Microscopically, the solid area was characterised by many rounded or angular ossicles in a cellular fibrous stroma. The stromal cells were spindle-like or stellate. Next-generation sequencing detected a frame shift mutation of the SETD2 gene, while the copy number was normal. Conclusions Our findings suggest further genetic studies should be performed to assess whether this mutation is related to tumour genesis.

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Juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of mandible

Cited by 5 publications

References 10 publications

Recurrent Juvenile Psammomatoid Ossifying Fibroma with Secondary Aneurysmal Bone Cyst of the Maxilla: A Case Report and Review of Literature

Recurrent Juvenile Psammomatoid Ossifying Fibroma with Secondary Aneurysmal Bone Cyst of the Maxilla: A Case Report and Review of Literature

Juvenile psammomatoid ossifying fibroma of the maxilla and mandible: A systematic review of published case reports

First presentation of a frameshift mutation in the SETD2 gene of a juvenile psammomatoid ossifying fibroma (JPOF) associated with an aneurysmal bone cyst

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