Juvenile Rheumatoid Arthritis

Johnson, Norman J.; Dodd, Katharine

doi:10.1016/s0025-7125(16)34701-0

Cited by 22 publications

(4 citation statements)

References 31 publications

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“…Although not mentioned in Still's original article, the rash of SJIA was clearly described by Johnson and Dodd in 1955, Isdale and Bywaters in 1956, and Calabro and Marchesano in 1968 (14–17). The same rash is characteristic of AOSD (6–12).…”

Section: Discussionmentioning

confidence: 98%

A Pruritic Linear Urticarial Rash, Fever, and Systemic Inflammatory Disease in Five Adolescents: Adult‐Onset Still Disease or Systemic Juvenile Idiopathic Arthritis sine Arthritis?

Prendiville

Tucker

Cabral

et al. 2004

Pediatric Dermatology

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The characteristic rash of systemic juvenile idiopathic arthritis is a transient erythematous eruption associated with a quotidian spiking fever. Usually asymptomatic, it can be pruritic, with dermatographism at sites of scratching or pressure. An illness similar to this entity in adults is designated adult-onset Still disease. The relationship between the pediatric and adult disease is uncertain and differences in case definition have evolved. Specifically, a sustained arthritis for at least 6 weeks is required for a diagnosis of systemic juvenile idiopathic arthritis, whereas transient arthritis and arthralgia are accepted criteria in adult-onset Still disease. We describe five patients less than 16 years of age who presented with an acute illness characterized by fever and a distinctive skin eruption. Intense pruritus and linear erythematous lesions flared with a spiking fever, usually in the late afternoon and evening. Periorbital edema/erythema and nonlinear urticarial lesions were also seen. Two children had splinter hemorrhages of the nail beds and one girl developed a fixed, scaling, pigmented, linear eruption. Severe malaise, myalgia, arthralgia, and leukocytosis were present in every patient. Other systemic manifestations included sore throat, transient arthritis, abdominal pain, lymphadenopathy, hepatomegaly, splenomegaly, hyperferritinemia, and hepatic dysfunction. No patient had a sustained arthritis. The course of the disease was variable. One patient, diagnosed with macrophage activation syndrome, recovered on oral naproxen. Two patients responded to systemic corticosteroid therapy. One girl developed status epilepticus and died from aspiration and asphyxia. A boy with severe hepatitis developed renal failure and thrombotic thrombocytopenic purpura and was treated with plasmapheresis, dialysis, and systemic corticosteroids; he had recurrent episodes of rash and fever into adult life. These children did not fulfill the case definition of systemic juvenile idiopathic arthritis because they lacked a persistent arthritis. Adolescent and adult patients with the same clinical and laboratory findings are described under the rubric of adult-onset Still disease. Recognition of the distinctive urticarial skin eruption and spiking fever is important in the diagnosis of a disease with severe morbidity and potentially life-threatening complications.

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Section: Discussionmentioning

confidence: 98%

A Pruritic Linear Urticarial Rash, Fever, and Systemic Inflammatory Disease in Five Adolescents: Adult‐Onset Still Disease or Systemic Juvenile Idiopathic Arthritis sine Arthritis?

Prendiville

Tucker

Cabral

et al. 2004

Pediatric Dermatology

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“…It appears that an allergic-toxic mechanism can also be implicated in arthralgias which occur in some cases of anaphylactoid purpura and in the arthritis, which is one of the extraintestinal manifestations of ulcerative colitis. undramatic picture to a fullblown, sepsis-like condition, represented by the syndrome of Still and Wissler's "subsepsis allergica" (28, 30, 33, 34), have been confirmed in several recent reports (8,9,17,22,25,29). It is generally agreed that most cases in children show certain common trends when compared to adults with the disease.…”

mentioning

confidence: 77%

The Diagnosis and Course of Rheumatoid Arthritis and Benign Aseptic Arthritis in Children1

Hellström

1961

Acta Paediatrica

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Summary Diagnostic criteria for rheumatoid arthritis adapted for the features of the disease in children have been suggested and used for a classification in a follow‐up examination. This study comprised 87 cases of aseptic arthritis of at least three weeks duration hospitalized in pediatric departments in Stockholm during 1952–1957. Those not fulfilling the criteria were labelled benign aseptic arthritis. They were compared with the rheumatoid arthritis cases as to the early clinical picture and the prognosis. The entirely different course in the two groups indicates that the suggested classification is of value in the prognostic prediction in cases of aseptic arthritis in children.

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“…However, prior to this, in 1903, two papers, one from England and the other from the United States, described cases with a form of ‘chronic joint disease in children as described by Still’ 8 , 9 . In a review of chronic childhood arthritis, Johnson and Dodd, in 1955, 10 noted that a rash was commonly seen in this condition, finding it in 14 of 20 patients. They noted its presence during fever, its disappearance following fever and the fact that it was occasionally urticarial.…”

Section: Classification Of the Diseasementioning

confidence: 99%

Still's Disease

Ansell¹

1991

Int J Clinical Practice

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George Frederic Still (1868‐1941) was one of 12 children, three of whom died in their first year of life and two later in childhood. He was brought up in Highbury, London. He obtained a scholarship to Merchant Taylor's School and then a further scholarship to Caius College, Cambridge, where he achieved a first class honours in the Classical Tripos. He studied medicine at Guy's Hospital, London, qualifying in 1893. His first appointment was as a house physician at Guy's. He then went to the Hospital for Sick Children, Great Ormond Street, London, firstly as a house physician and then as a medical registrar and pathologist. It was from here that, in November 1896, Dr Archibald Garrod read Still's classic paper entitled ‘On a form of chronic joint disease in children’ to the Royal Medical and Chirurgical Society. The paper was published in their transactions the following year1 and was also the subject of Still's Cambridge MD thesis.

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Juvenile Rheumatoid Arthritis

Cited by 22 publications

References 31 publications

A Pruritic Linear Urticarial Rash, Fever, and Systemic Inflammatory Disease in Five Adolescents: Adult‐Onset Still Disease or Systemic Juvenile Idiopathic Arthritis sine Arthritis?

A Pruritic Linear Urticarial Rash, Fever, and Systemic Inflammatory Disease in Five Adolescents: Adult‐Onset Still Disease or Systemic Juvenile Idiopathic Arthritis sine Arthritis?

The Diagnosis and Course of Rheumatoid Arthritis and Benign Aseptic Arthritis in Children1

Still's Disease

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