Juvenile rheumatoid arthritis, human leukocyte antigen, and other immunoglobulin supergene family polymorphisms

Maksymowych, Walter P.; Kerckhove, Catherine Van; Glass, David N.

doi:10.1016/0002-9343(88)90377-4

Cited by 10 publications

References 9 publications

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Prolonged Continuous Acyclovir Treatment of Normal Adults With Frequently Recurring Genital Herpes Simplex Virus Infection

Kaplowitz¹

1991

JAMA

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In this 3-year study of suppressive acyclovir for recurrent genital herpes, patients with more than six recurrences per year were randomized initially to 400 mg of acyclovir or placebo orally two times per day, with recurrences treated with 200 mg of acyclovir five times per day for 5 days. In the second year of the study, all patients received acyclovir as a daily suppressive or intermittent acute therapy; in the third year, all received daily acyclovir. Among 525 patients completing 3 study years, 289 received 3 years of suppressive therapy and 236 received 1 year of acute therapy followed by 2 years of suppressive therapy. Of those who completed the third year, 61% were recurrence free that year; 25% of the suppressive therapy-only group were recurrence free for all 3 years. The annual recurrence rate dropped from more than 12 recurrences per year at baseline to 1.0 (suppressive therapy) and 1.4 (acute and suppressive therapy) recurrences during the third year. No significant toxic effects were detected. Daily suppressive acyclovir therapy was effective and well tolerated.

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Prolonged Continuous Acyclovir Treatment of Normal Adults With Frequently Recurring Genital Herpes Simplex Virus Infection

Kaplowitz¹

1991

JAMA

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Herpes simplex virus type-2 ulcers resistant to acyclovir in an AIDS patient — Successful treatment with foscarnet

et al. 1991

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The case of a 25-year-old homosexual man with large inguinal and perianal ulcers is reported. He had been pretreated extensively with acyclovir. Herpes simplex virus (HSV) was identified in the ulcer tissue by in-situ hybridization. No clinical improvement with acyclovir but a prompt response to foscarnet was noted. In a relapse after 11 weeks an acyclovir-resistant HSV type 2 was isolated. Again, a prompt response to foscarnet was noted. The case is presented in detail, and the clinical impact of resistance of HSV to acyclovir is discussed.

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Both HLA class II and class III DNA polymorphisms are linked to juvenile rheumatoid arthritis susceptibility

Vicário¹,

Martı́nez-Laso²,

Gómez-Reino³

et al. 1990

Clinical Immunology and Immunopathology

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Juvenile rheumatoid arthritis, human leukocyte antigen, and other immunoglobulin supergene family polymorphisms

Cited by 10 publications

References 9 publications

Prolonged Continuous Acyclovir Treatment of Normal Adults With Frequently Recurring Genital Herpes Simplex Virus Infection

Prolonged Continuous Acyclovir Treatment of Normal Adults With Frequently Recurring Genital Herpes Simplex Virus Infection

Herpes simplex virus type-2 ulcers resistant to acyclovir in an AIDS patient — Successful treatment with foscarnet

Both HLA class II and class III DNA polymorphisms are linked to juvenile rheumatoid arthritis susceptibility

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