Juvenile rheumatoid arthritis of the knee: MR evaluation with Gd-DOTA.

C, Hervé-Somma; Sebag, G.; Prieur, Anne Marie; Bonnerot, V; Lallemand, D

doi:10.1148/radiology.182.1.1727317

Cited by 116 publications

(45 citation statements)

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“…One major problem with the validation of Vsm determination by MRI lies in the identification of appropriate gold standards. A semi-automated method based on computerized counting of pixels fulfilling certain criteria can be used [16,17,18,19], volume measurements can be restricted to one or few slices per joint, or a semi-quantitative grading of synovial hypertrophy can be performed [3,20,21,22]. These methods are less time-consuming and faster and more attractive for applicability in larger clinical studies or in clinical routine.…”

Section: Discussionmentioning

confidence: 99%

MRI of the arthritic small joints: comparison of extremity MRI (0.2 T) vs high-field MRI (1.5 T)

et al. 2001

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The aim of this study was to compare the diagnostic capabilities of extremity MRI (E-MRI) with high-field MRI in arthritic small joints, and to evaluate the patients' acceptance and perceptions of the two MR systems. One hundred three patients (group 1 = 28 patients with RA < 3 years, group 2 = 25 patients with reactive and psoriatic arthritis and mixed connective tissue disease, group 3 = 25 patients with rheumatoid arthritis (RA) more than 3 years and group 4 = 25 patients with arthralgia) underwent dedicated E-MRI and high-field MRI of the wrist and finger joints. Coronal short tau inversion recovery and transversal 3D T1-weighted images before and after gadodiamide (Gd) were performed in both cases to outline the volume of the synovial membrane (Vsm) and to evaluate joints with enhancement, effusion, bone edema, and erosions. Investigators blinded to the clinical findings evaluated the images. Patients' compliance and acceptance of E-MRI and high-field MRI were evaluated. The median Vsm obtained on E-MRI did not differ significantly from that obtained on high-field MRI. Vsm = 1 ml (E-MRI) and 1.1 ml (high-field MRI) before Gd and Vsm = 0.1 ml (E-MRI) and 0 ml (high-field MRI) after Gd (Wilcoxon test, p > 0.05). The difference in agreement was 8% for joint enhancement, 2% for joint effusion, 3% for bone edema, and 4% for bone erosions. Of the patients, 64% preferred E-MRI due to more comfortable positioning and less claustrophobia and noise. Extremity MRI of the small arthritic joints is comparable to high-field MRI and more readily accepted than high-field MRI by this patient group.

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Section: Discussionmentioning

confidence: 99%

MRI of the arthritic small joints: comparison of extremity MRI (0.2 T) vs high-field MRI (1.5 T)

et al. 2001

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“…Both features have low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The very vascular proliferative synovitis has been shown to enhance with intravenously injected gadolinium-containing compounds, although imaging must be performed immediately after injection to avoid diffusion of contrast into the joint [6]. Chronic synovitis often has low signal intensity on both T1-and T2-weighted sequences.…”

Section: Juvenile Rheumatoid Arthritismentioning

confidence: 99%

MRI of the pediatric shoulder: nontraumatic lesions

et al. 1997

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Magnetic resonance imaging is an established technique for imaging the shoulder because it demonstrates clearly the articular surfaces, medullary canal and the extra-articular soft tissues which can be affected in shoulder disorders. The value of MR imaging in the evaluation of the traumatized shoulder has been described [1]; however, few cases of MR imaging in nontraumatic disorders in children have been reported. We reviewed the findings in 55 children undergoing MRI of the shoulder for nontraumatic conditions and included selected cases showing a broad range of imaging findings.

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“…In addition, MR is not associated with any radiation exposure. Although standard gadopentetate-enhanced MR imaging provides a high sensitivity for the detection of arthritis, it provides only a limited specificity (17)(18)(19)(20), because the enhancement of inflammatory tissues overlaps with the enhancement patterns of normal joints and other pathologic processes (17,21,22). New FR-based gadolinium (Gd) chelates are expected to improve the sensitivity and specificity of MR imaging for the diagnosis of arthritis, similar to the radiotracers mentioned above.…”

Section: Introductionmentioning

confidence: 99%

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

Saborowski

Simon

Raatschen

et al. 2007

Contrast Media & Molecular

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The purpose of this study was to investigate if the new folate receptor-targeted Gd-chelate P866 may enhance immune-mediated arthritis. A monoarthritis was induced in the right knee of 15 Sprague-Dawley rats. MR imaging of both knees was performed at 2 T before and up to 2 h and 24 h after injection (p.i.) of P866 (n = 3 dose finding study and n = 6, 0.02 mmol Gd/kg), the non-FR targeted P866 analog P1001 (n = 3 at 24 h after P866-administration, 0.02 mmol Gd/kg) or Gd-DOTA (n = 6, 0.1 mmol Gd/kg). Pulse sequences comprised T(1)-SPGR 80 degrees /50 ms/1.7 ms (flip angle/TR/TE) and inversion recovery 10 degrees /3000 ms/1500 ms/50-3050, 10 000 ms (flip angle/TR/TE/TI) sequences. DeltaSI-data and T(1)-relaxation times of arthritic knees and contralateral normal knees were determined. Folate receptor expression was confirmed with histopathology. All three contrast agents showed an initial perfusion effect with significantly higher DeltaSI-data of arthritic knees compared with normal knees (p < 0.05). In addition, P866, but not P1001 or Gd-DOTA, showed a prolonged enhancement of the synovitis. Compared with precontrast values, the T(1)-relaxation times of inflamed synovia were significantly decreased at 2 h p.i. of P866 (p < 0.05), but not P1001 or Gd-DOTA (p > 0.05). Histopathology confirmed the presence of folate receptors in the inflamed joints, but not normal joints. Thus, results suggest a specific accumulation of the folate receptor-targeted Gd-chelate P866 in this arthritis model.

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Juvenile rheumatoid arthritis of the knee: MR evaluation with Gd-DOTA.

Cited by 116 publications

References 0 publications

MRI of the arthritic small joints: comparison of extremity MRI (0.2 T) vs high-field MRI (1.5 T)

MRI of the arthritic small joints: comparison of extremity MRI (0.2 T) vs high-field MRI (1.5 T)

MRI of the pediatric shoulder: nontraumatic lesions

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

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