Imaging plays a key role in the evaluation of patients with known or suspected arthritis. Following clinical and laboratory assessment, radiography is the traditional imaging starting point. Other potential modalities include ultrasound, computed tomography, nuclear medicine, and magnetic resonance imaging. This chapter will present the following conditions: juvenile idiopathic arthritis (JIA) along with the enthesitis-related arthritis (ERA) subtype, hemophilia, and pigmented villonodular synovitis (PVNS). Synovial chondromatosis and dermatomyositis are discussed in Chaps. 12 and 24 , respectively.