Juvenile Spondyloarthritis: What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation?

Sh, Tay; Yeo, Joo Guan; Leong, Jing Yao; Albani, Salvatore; Arkachaisri, Thaschawee

doi:10.3389/fmed.2021.666772

Cited by 8 publications

(7 citation statements)

References 117 publications

(153 reference statements)

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“…Juvenile spondyloarthritis (JSpA) may be defined as a heterogeneous group of diseases, with varying degrees of peripheral and axial arthritis and enthesitis and a strong association with human leukocyte antigen-B27 (HLA-B27), affecting children under 16. JSpA is a generic term that not only includes children meeting the criteria for juvenile idiopathic arthritis (JIA), categories of seronegative or seropositive enthesitis related arthritis (ERA) and juvenile psoriatic arthritis (JPsA), but also juvenile ankylosing spondylitis (JAS), reactive arthritis and inflammatory bowel disease (IBD)-associated arthritis [ 9 ]. ERA and JPsA account for most cases of JSpA, with ERA being the most common (50%).…”

Section: Juvenile Spondyloarthritismentioning

confidence: 99%

“…The clinical feature that differentiates pediatric CRMO from SpA is mainly the localization of inflammation. In CRMO, inflammation is mainly localized in the bones and affects the metaphysis of the long bones, especially in the lower extremities (78%) near the knees and ankles, as well as in the axial skeleton (48–68%) [ 9 ]. In SpA, the main target sites are the spine and the pelvic bones [ 24 ].…”

Section: Links Between Crmo and Jspamentioning

confidence: 99%

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Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Juvenile Spondyloarthritis (JSpA): To What Extent Are They Related?

Koné‐Paut

Mannes

Dusser

2023

JCM

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Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disease occurring mainly in the pediatric age group (before 16 years) and generally presents as a separate entity. Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome combines osteoarticular and cutaneous involvement, similar to CRMO, and falls into the spectrum of spondyloarthritis (SpA). The fact that a patient can progress from one disease to another raises the question of whether CRMO, like SAPHO, could fall within the spectrum of SpA, ranging from a predominantly osteoarticular form to an enthesitic form with more or less marked skin involvement. In this review, we set out to discuss this hypothesis by highlighting the differences and similarities between CRMO and juvenile SpA in clinical, radiological and pathophysiological aspects. A common hypothesis could potentially consider intestinal dysbiosis as the origin of these different inflammatory diseases. Interindividual factors such as gender, environment, genetics and/or epigenetic background could act as combined disease modifiers. This is why we suggest that pathophysiology, rather than clinical phenotype, be used to reclassify these diseases.

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Section: Juvenile Spondyloarthritismentioning

confidence: 99%

Section: Links Between Crmo and Jspamentioning

confidence: 99%

Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Juvenile Spondyloarthritis (JSpA): To What Extent Are They Related?

Koné‐Paut

Mannes

Dusser

2023

JCM

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“…The impact of biomechanical forces has been underexplored in juvenile SpA (jSpA). 21 Several unanswered questions remain, including whether walking with adultlike velocity with immature lower limbs 22 and aberrant tendon stiffening amidst increasing body mass during childhood 23 apply increased forces on the entheses of susceptible children and hence favour disease development.…”

Section: Juvenile Spamentioning

confidence: 99%

Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with

Iyer,

Hwang,

Ridley

et al. 2023

RMD Open

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Increasing evidence suggests that there is a pivotal role for physical force (mechanotransduction) in the initiation and/or the perpetuation of spondyloarthritis; the review contained herein examines that evidence. Furthermore, we know that damage and inflammation can limit spinal mobility, but is there a cycle created by altered spinal mobility leading to additional damage and inflammation?Over the past several years, mechanotransduction, the mechanism by which mechanical perturbation influences gene expression and cellular behaviour, has recently gained popularity because of emerging data from both animal models and human studies of the pathogenesis of ankylosing spondylitis (AS). In this review, we provide evidence towards an appreciation of the unsolved paradigm of how biomechanical forces may play a role in the initiation and propagation of AS.

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“…Therefore, it is plausible that patients with this JIA subtype may develop spondylitis over time. However, HLA-B27 is also present in 5–15% of the general population, limiting its specificity as a diagnostic test [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review

Ventura,

Meira-Blanco,

Legidos-García

et al. 2024

IJMS

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Juvenile Idiopathic Arthritis (JIA) is currently the most common chronic rheumatic disease in children. It is known to have no single identity, but a variety of diagnoses. Under-diagnosis is a barrier to early treatment and reduced complications of the disease. Other immune-mediated diseases may coexist in the same patient, making research in this area relevant. The main objective was to analyse whether links could be established between the molecular basis of JIA and other immune-mediated diseases. Early diagnosis may benefit patients with JIA, which in most cases goes undetected, leading to under-diagnosis, which can have a negative impact on children affected by the disease as they grow up. Methods: We performed a PRISMA systematic review focusing on immune molecules present in different autoimmune diseases. Results: A total of 13 papers from different countries dealing with the molecular basis of JIA and other immune diseases were evaluated and reviewed. Conclusions: Most of the autoimmune diseases analysed responded to the same group of drugs. Unfortunately, the reason for the under-diagnosis of these diseases remains unknown, as no evidence has been found to correlate the immunomolecular basis with the under-diagnosis of these immune-mediated diseases. The lack of information in this area means that further research is needed in order to provide a sound basis for preventing the development of immune-mediated diseases, especially in children, and to improve their quality of life through early diagnosis and treatment.

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Juvenile Spondyloarthritis: What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation?

Cited by 8 publications

References 117 publications

Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Juvenile Spondyloarthritis (JSpA): To What Extent Are They Related?

Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Juvenile Spondyloarthritis (JSpA): To What Extent Are They Related?

Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with

Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review

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