Juvenile Xanthogranuloma Involving the Eye and Ocular Adnexa

Samara, Wasim A.; Khoo, Chloe T.L.; Say, Emil Anthony T.; Saktanasate, Jarin; Eagle, Ralph C.; Shields, Jerry A.; Shields, Carol L.

doi:10.1016/j.ophtha.2015.06.009

Cited by 84 publications

(74 citation statements)

References 24 publications

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“…In our case, multiple nodules on both eyelids developed after or at the same time as cutaneous lesions when our patient was 10 years old. Within ocular involvements, eyelid involvements were found in 6-25% of patients [15,32]. Most reports of JXG were a solitary lesion in the eyelid [19,20,21,22,28].…”

Section: Discussionmentioning

confidence: 99%

“…Samara et al [15] reported that periocular JXG appeared at a later age, at a mean age of 6.5 years (median, 2.1 years). The age of onset of JXG in our patient was 10 years.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular involvement in patients with cutaneous JXG is the most common symptom in extracutaneous JXG [2,13,14,15]. Ocular involvement of JXG includes the orbit, eyelid, conjunctiva, uvea, retina, and optic disc [15,16,17,18,19,20,21,22,23,24,25,26,27,28].…”

Section: Introductionmentioning

confidence: 99%

“…Ocular involvement of JXG includes the orbit, eyelid, conjunctiva, uvea, retina, and optic disc [15,16,17,18,19,20,21,22,23,24,25,26,27,28]. With regard to ocular involvement, a lesion of the iris in cutaneous JXG that has a risk of causing spontaneous hyphema is the most frequent finding [15,25]. The frequency of occurrence of lesions of the iris in JXG is less than that of eyelid nodules in JXG [15].…”

Section: Introductionmentioning

confidence: 99%

“…With regard to ocular involvement, a lesion of the iris in cutaneous JXG that has a risk of causing spontaneous hyphema is the most frequent finding [15,25]. The frequency of occurrence of lesions of the iris in JXG is less than that of eyelid nodules in JXG [15]. Most patients with JXG who have eyelid lesions present with a solitary lesion [19,20,21,22,28].…”

Section: Introductionmentioning

confidence: 99%

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Multiple Juvenile Xanthogranuloma of the Eyelids

2017

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Juvenile xanthogranuloma (JXG) is a rare and benign tumor in infants. A solitary lesion on the eyelid has been reported in patients with JXG. We report a 15-year-old boy with multiple involvement of JXG on both eyelids. A mass on the left inner canthus was resected because of disturbance of the visual field and a risk of malignancy in terms of central ulceration in the lesion. The mass was examined by light microscopy. The mass had Touton giant cells with a wreath of nuclei surrounded by foamy histiocytes. No malignancy was observed. The mass showed no recurrence after resection.

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Section: Discussionmentioning

confidence: 99%

“…Samara et al [15] reported that periocular JXG appeared at a later age, at a mean age of 6.5 years (median, 2.1 years). The age of onset of JXG in our patient was 10 years.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple Juvenile Xanthogranuloma of the Eyelids

2017

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Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children

et al. 2017

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IMPORTANCE Conjunctival tumors in children are usually benign and rarely malignant. OBJECTIVE To evaluate clinical features of conjunctival tumors in children by comparing benign tumors with their malignant counterparts. DESIGN, SETTING, AND PARTICIPANTS This retrospective case series reviewed 806 cases of conjunctival tumor in children (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and July 1, 2015. This study included 262 children who were part of a published review. MAIN OUTCOMES AND MEASURES Features of benign and malignant tumors were compared. Data were collected on patient demographics, tumor features, and specific diagnoses to determine findings related to each tumor. RESULTS Among the 806 patients with conjunctival tumor, the top 5 diagnoses included nevus (492 [61%]), benign reactive lymphoid hyperplasia (BRLH) (38 [5%]), nodular conjunctivitis (31 [4%]), dermoid (30 [4%]), and primary acquired melanosis (27 [3%]). Overall, conjunctival tumors were benign (779 [97%]) or malignant (27 [3%]), including melanoma (18 [2.2%]) and lymphoma (9 [1.1%]). The mean age at detection was 11 years for benign tumors and 14 years for malignant tumors (P = .005), with mean difference of 3 years (95% CI, 1.2-4.6). The relative frequency of any malignancy (per all conjunctival tumors) by age bracket (0-5 years, >5-10 years, >10-15 years, and >15-<21 years) was 1%, 2%, 3%, and 7%, respectively. A comparison between nevus and melanoma found differences with melanoma in the 10 to 15 years age bracket (29% vs 61%; difference of 32% [95% CI, 10%-55%];

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Ocular Juvenile Xanthogranuloma in an Older Teenager

Crowell

Burkholder

2020

JAMA Ophthalmol

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A 19-year-old man presented with recurrent left eye redness and photophobia for the past year. The patient had previously been treated with topical corticosteroid therapy, which provided temporary relief of his symptoms. Visual acuity was 20/20 OU with normal intraocular pressures. The results from the slitlamp examination of the right eye were within normal limits (Figure 1A). Examination results of the left eye demonstrated 2+ diffuse conjunctival hyperemia, 1+ anterior chamber cell, and a vascularized iris infiltrate (Figure 1B). Results of the dilated fundus examination were within normal limits in both eyes. Ultrasound biomicroscopy of the left eye demonstrated areas of ciliary body thickening 360°and a thickened iris pupillary margin superiorly and nasally. A full review of systems was negative for other abnormalities including skin lesions. Test results for tuberculosis and syphilis were negative.

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Juvenile Xanthogranuloma Involving the Eye and Ocular Adnexa

Cited by 84 publications

References 24 publications

Multiple Juvenile Xanthogranuloma of the Eyelids

Multiple Juvenile Xanthogranuloma of the Eyelids

Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children

Ocular Juvenile Xanthogranuloma in an Older Teenager

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