Juxtaglomerular Cell Tumor: Importance of Clinical Suspicion

Baert, Jeroen; Damme, B Van; Oyen, Raymond; Poppel, H. Van; Baert, Luc

doi:10.1159/000282716

Cited by 10 publications

(11 citation statements)

References 8 publications

(12 reference statements)

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“…Nine cases (11%) had persistent hypertension with an average follow-up period of 10 months (range 5-18 months) [3,9,11,23,40,45,46,52,60]. One of these cases was normotensive postoperatively, but developed persistent hypertension 1.5 years after surgery [52].…”

Section: Postoperative Resultsmentioning

confidence: 99%

Reninoma: case report and literature review

Wong¹,

Hsu²,

Perlroth³

et al. 2008

Journal of Hypertension

135

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Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients. The subject had persistent elevation of both plasma renin activity (PRA) and aldosterone. Imaging studies revealed the presence of a lesion in the renal cortex, which was further identified as a renin-producing lesion via selective venous catheterization following administration of an angiotensin-converting enzyme inhibitor (ACE-I). Following partial nephrectomy, the PRA and plasma aldosterone levels declined rapidly and the blood pressure and potassium supplementation requirements normalized. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis.

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Section: Postoperative Resultsmentioning

confidence: 99%

Reninoma: case report and literature review

Wong¹,

Hsu²,

Perlroth³

et al. 2008

Journal of Hypertension

135

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show abstract

“…Approximately 10% of patients are mildly hypertensive following resection of the tumor, although the hypertension is always markedly decreased from preoperative levels. 17,20,31,51,61 Bonsib and ❚Image 9❚ Juxtaglomerular cell tumor (JGCT) showing strong cytoplasmic positivity for smooth muscle actin in many of the tumor cells. This staining pattern was typical of JGCT in that only a portion of the tumor was positive for actin (smooth muscle actin, ×100).…”

mentioning

confidence: 99%

Juxtaglomerular Cell Tumor

et al. 2001

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We studied 4 new cases of juxtaglomerular cell tumor and compared their morphologic and immunohistochemicalfeatures with 2 renal hemangiopericytomas and 5 cutaneous glomus tumors. The juxtaglomerular tumors were resectedfrom 2 males and 2 females (mean age at diagnosis, 23 years). Three patients manifested with severe hypertension. Tumors ranged from 2.2 to 8.0 cm and were well circumscribed. The tumors consisted of solid sheets and nodules of variably sized tumor cells with round, oval, and spindled nuclei alternating with edematous microcystic foci. Nuclear atypia, present in all tumors, was a prominent feature in 2. Mitotic activity was not identified. All cases showed hemorrhage, numerous mast cells, and thick-walled blood vessels. Unusual features included coagulative tumor necrosis, a hemangiopericytoma-like vascular pattern, and hyalinized stroma. All tumors were immunoreactive for CD34 and actin. Ultrastructural analysis revealed the presence of rhomboid-shaped renin protogranules. Patients were treated by partial or radical nephrectomy and followed up for 14 to 48 months. There were no recurrences or metastases. The characteristic clinical and morphologic features of juxtaglomerular cell tumor permit distinction from renal hemangiopericytoma and other renal tumors.

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“…In this study, 6 out of 9 JGCTs patients received nephron-sparing surgery. With surgical excision, the patients may not need medication (as in the present study) or markedly reduce the medications for blood pressure control ( 16 ).…”

Section: Discussionmentioning

confidence: 92%

Characterization and Management of Juxtaglomerular Cell Tumor: Analysis of 9 Cases and Literature Review

Jiang

Yang

et al. 2020

Balkan Med J

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Aims: Juxtaglomerular cell tumor is a rare kidney tumor. This study aimed to report the clinic features of juxtaglomerular cell tumor and our treatment experience. Methods: The medical records of 9 juxtaglomerular cell tumor patients treated in our hospital from 1997 to 2017 were retrospectively reviewed. Clinical characteristics, immunohistochemical findings, treatments and outcomes were collected. Results: The mean age of 9 patients was 24±8.1 years (range: 18-37). All cases had symptoms of hypertension, hyperaldosteronism, high plasma renin, high plasma angiotensin II. Four cases had hypokalemia. The renal masses were found by enhanced contrast tomography in all patients. One case received ultrasound-guided ablation and was clinically diagnosed with juxtaglomerular cell tumor. Among the remaining 8 cases, 2 cases received nephrectomy while 6 underwent partial nephrectomy. The 8 cases were pathologically diagnosed with juxtaglomerular cell tumor. Immunohistochemical findings showed that juxtaglomerular cell tumor was positive for vimentin, CD34, and actin but negative for chromogranin A. After treatment, all the patients had normal levels of blood pressure, serum renin activity, potassium, and aldosterone. No patients had tumor progress or metastasis within a median follow-up period of 94 (range: 33-241) months. Conclusion: Hypertension combined with hyperaldosteronism and hypokalemia secondary to high plasma renin activity are the typical symptoms of juxtaglomerular cell tumor. Partial nephrectomy is an optimal treatment for juxtaglomerular cell tumor.

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Juxtaglomerular Cell Tumor: Importance of Clinical Suspicion

Cited by 10 publications

References 8 publications

Reninoma: case report and literature review

Reninoma: case report and literature review

Juxtaglomerular Cell Tumor

Characterization and Management of Juxtaglomerular Cell Tumor: Analysis of 9 Cases and Literature Review

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