Juxtaglomerular cell tumor in pregnancy

Henderson, Natalie L.; Mason, Richard C.

doi:10.1016/s0029-7844(01)01547-2

Cited by 10 publications

(11 citation statements)

References 6 publications

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“…The mean duration of hypertension was 47 months (range 0-23 years; median 24 months). In four cases, hypertension was first detected during pregnancy [36,40,45,48].…”

Section: Discussionmentioning

confidence: 99%

Reninoma: case report and literature review

Wong¹,

Hsu²,

Perlroth³

et al. 2008

Journal of Hypertension

135

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Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients. The subject had persistent elevation of both plasma renin activity (PRA) and aldosterone. Imaging studies revealed the presence of a lesion in the renal cortex, which was further identified as a renin-producing lesion via selective venous catheterization following administration of an angiotensin-converting enzyme inhibitor (ACE-I). Following partial nephrectomy, the PRA and plasma aldosterone levels declined rapidly and the blood pressure and potassium supplementation requirements normalized. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis.

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“…The mean duration of hypertension was 47 months (range 0-23 years; median 24 months). In four cases, hypertension was first detected during pregnancy [36,40,45,48].…”

Section: Discussionmentioning

confidence: 99%

Reninoma: case report and literature review

Wong¹,

Hsu²,

Perlroth³

et al. 2008

Journal of Hypertension

135

View full text Add to dashboard Cite

show abstract

“…Among the number of reninoma cases reported (12)(13)(14)(15)(16)(17), the patient of the present study case is the 7th study reporting a patient with reninoma during pregnancy. According to previous studies, the majority of reninomas present in the form of solitary tumor (11,18).…”

Section: Discussionmentioning

confidence: 78%

Reninoma coexisting with adrenal adenoma during pregnancy: A case report

et al. 2017

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Abstract. Reninoma is a rare form of secondary hypertension. The present study reported a case of reninoma that coexisted with an adrenal adenoma in a young female with secondary hypertension during pregnancy. The patient, a 31-year-old female exhibiting hypertension for >1 year, developed a mass in the right adrenal gland, which was detected by an ultrasound scan in the 33rd gestational week. In addition, a well-defined solid mass on the left kidney was detected by a magnetic resonance imaging scan1 month subsequent to the termination of the pregnancy. The blood pressure (BP) of the patient did not change subsequent to the laparoscopic right adrenalectomy. The patient subsequently underwent laparoscopic left partial nephrectomy 2 months later. The BP levels demonstrated a significant reduction from 177/115 to 125/80 mmHg in the same day postoperatively, and stabilized to be within the normal range. The BP level of the patient remained within the normal range subsequent to a 6-month follow-up. Pathological analysis revealed reninoma on the left kidney. The present study aimed to provide information for radiologists who may encounter this type of benign tumor in the future, which exhibits elevated BP levels. IntroductionReninomas, or renal juxtaglomerular cell tumors, develop within the juxtaglomerular apparatus through the evolution of small artery smooth muscle cells. These tumor cells produce excessive amounts of renin that results in severe hypertension with hypokalemia and hyperaldosteronism, through the activity of the renin-angiotensin aldosterone system (1). It is a rare form of secondary hypertension. Removing the reninoma results in the conversion of increased blood pressure to normal blood pressure (2). Therefore, perioperative hemodynamic management is important in patients who undergo surgery for the removal of a reninoma.Adrenal adenoma is a benign neoplasm, which is derived from cells of the adrenal cortex, and may be functionally active or nonfunctional (3). Functional adrenal adenoma is able to cause aldosteronism or Cushing's syndrome. Primary aldosteronism (PA) is characterized by autonomous aldosterone production, which is a cause of secondary hypertension (4). Evidence has developed over the past decades and led to the recognition that autonomous adrenal aldosterone production, termed primary aldosteronism, is common in hypertensive patients. Between 5 and 13% of patients with hypertension have primary aldosteronism (5).The present study reported a rare case of reninoma coexisting with an adrenal adenoma in a young female with secondary hypertension during pregnancy. Case reportA 2.5-cm mass was detected on the right adrenal gland of a 31-year-old pregnant female with hypertension in her 33rd gestational week by an ultrasound scan. The patient presented with a personal history of elevated blood pressure (BP) for several months prior to conception, and exhibited a family history of hypertension. There were no other abnormalities found by the ultrasounds of the adrenal gland and the renal arter...

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“…There are at least two reports of JGCT occurring in pregnancy [4,5]. In the first case, the patient miscarried after a nephrectomy was performed [4].…”

Section: Discussionmentioning

confidence: 99%

“…In the first case, the patient miscarried after a nephrectomy was performed [4]. In the second case, hypertension was diagnosed and attributed to pregnancy.…”

Section: Discussionmentioning

confidence: 99%