Middle Devonian magnesian andesites (MAs) are widely distributed in south Altay and Carboniferous MAs are present in Alataoshan and west-and east-Tianshan in the north Xinjiang region. These MAs are andesitic rocks with 53-65% SiO 2 , \1% (0.21-1.08%; average of 0.72%) TiO 2 , and C50 Mg # . Magnesian dacites and diorites, with 52.38-66.91% SiO 2 , \0.30% TiO 2 and C42 Mg # commonly occur with these MAs. Relative to boninites, MAs have lower MgO contents (average 6.39%) but higher Ti, K and Na. They have characteristic flat chondritenormalized REE patterns with weak to no Eu anomalies (Eu depletion, or Eu/Eu* = 0.65-1.15), low (La/Yb) N (0.98-6.4, mostly 4±) and low total REE contents (15-95 ppm). They also have high contents of compatible elements Cr and Ni (72-790 and 29-276 ppm, respectively). Their relative depletion in high field strength elements Nb, Ta and Ti, and relative enrichment in mobile large-ion lithophile elements Rb, K and Pb are evident on primitive mantle-normalized trace element spidergrams. If magnesian andesites are melts coming from the subducted oceanic crust, as proposed elsewhere, then the relatively high Y contents ([15 ppm), low Sr/Y ratios (4.4-6.2), low (La/Yb)N, and high Mg # of the MAs in north Xinjiang provide evidence of interaction of such melts with mantle wedge peridotite. New petrographic, chemical and isotopic [( 143 Nd/ 144 Nd)I = 0.51221-0.51255 (eNd(t) +0.28 to +7.2); ( 87 Sr/ 86 Sr)I = 0.7029-0.7065] data suggest that the petrogenesis of the MAs in the north Xinjiang region may have involved: (1) multiple source materials including subducted oceanic slab, juvenile crustal materials (mainly volcanic-volcanoclassic rocks with low maturity and clear mantle geochemical signatures) coming from the forearc accretionary prism and mantle wedge peridotite; (2) a combination of different petrogenetic processes including partial melting of subducted oceanic slab and juvenile crustal materials, followed by interaction of slab melts with the mantle wedge peridotite; (3) high geothermal gradient creating a high temperature ([1,000°C) environment in a volatile-rich source region; (4) unique tectonic settings including oblique subduction, slab break off resulting in slab window formation and asthenosphere upwelling, and subduction erosion resulting in transfer of forearc accretionary materials into the source region of MA magma.