Juzen-taiho-to, an Herbal Medicine, Activates and Enhances Phagocytosis in Microglia/Macrophages

Liu, Huayan; Wang, Jun; Sekiyama, Atsuo; Tabira, Takeshi

doi:10.1620/tjem.215.43

Cited by 20 publications

(15 citation statements)

References 37 publications

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“…Our previous study also indicated that the HF488-Aβ 1-42 phagocytosis by the mouse primary microglia was enhanced by LPSp treatment (11). These results are consistent with recent studies reporting that Juzen-taiho-to (JTT), a Chinese herbal medicine, and LPS, a major macrophageactivating substances found in JTT, increased the microglial phagocytosis of Aβ 1-42 in primary microglia (12), and monophosphoryl lipid A, and LPS, increased Aβ 1-42 phagocytosis by mouse microglia cell line BV-2 (10). However, further studies were required for elucidating the molecular mechanisms underlying the promotory effect of Aβ phagocytosis by LPSp.…”

Section: Discussionsupporting

confidence: 93%

Lipopolysaccharides Derived from Pantoea agglomerans Can Promote the Phagocytic Activity of Amyloid β in Mouse Microglial Cells

Kobayashi

Inagawa

Kohchi

et al. 2017

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Section: Discussionsupporting

confidence: 93%

Lipopolysaccharides Derived from Pantoea agglomerans Can Promote the Phagocytic Activity of Amyloid β in Mouse Microglial Cells

Kobayashi

Inagawa

Kohchi

et al. 2017

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“…Recently, Liu et al [12] reported that JTT activated microglia and induced microglial proliferation and activation without an increase in nitric oxide production. Furthermore, bone marrow derived macrophages from JTT-treated mice showed enhanced phagocytosis of fibrillar Aβ 1−42 .…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effects of the Herbal Medicine, Juzen-taiho-to, on Amyloid-β Burden in a Mouse Model of Alzheimer's Disease

Hara

Kataoka

Anan

et al. 2010

JAD

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Abstract. Innate immunity, especially that involving macrophage function, reportedly diminishes with advancing age and in patients with Alzheimer's disease (AD). In this study, we tried to elicit the non-specific activation of peripheral macrophages by oral administration of the herbal medicine Juzen-taiho-to (JTT), to assess its effect as a possible treatment for AD patients. Amyloid-β protein precursor transgenic mice were used as a model of AD to clarify the effect of JTT. Activated macrophages derived from bone marrow cross the blood-brain barrier, and then develop into microglia, which phagocytose aggregated amyloid-β (Aβ) in senile plaques. Here we show that orally administered JTT increased the number of CD11b-positive ramified microglia in the mouse brain. The immunohistochemical examination of brain sections stained with polyclonal anti-Aβ antibody showed reduced Aβ burden, and Aβ levels were also decreased in the insoluble fractions of brain homogenates, as determined by ELISA. Thus, the activation of peripheral macrophages by JTT might be a potential new therapeutic strategy for AD.

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“…The immunostimulatory effects of herbal medicines are widely known (1,2). In our previous study, it was demonstrated that juzentaihoto, a Japanese herbal medicine, increased and prolonged antibody production following an influenza vaccination in a human clinical experiment (13).…”

Section: Discussionmentioning

confidence: 99%

“…The immunostimulatory effects of herbal medicines, such as Kampo in Japan and Chinese herbal medicines, have been extensively reported. Herbal medicines are prescribed for infection and tumor, and one of their properties is strong immunostimulatory effects, including increased phagocytosis and antibody production (1,2). However, limited information is currently available regarding the immunostimulant components of these herbal medicines.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory effects of cell wall‑based nanoparticles in boiled Glycyrrhizae radix water extracts involves TLR4

et al. 2020

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A number of immunostimulant effects of herbal medicines have been reported; however, the underlying mechanisms of their immunostimulatory effects have not been elucidated in detail. Our previous study showed that sugar-based nanoparticles derived from cell walls acted as the immunostimulatory component of boiled Glycyrrhizae radix water extracts. Therefore, the aim of the present study was to clarify the molecular mechanisms by which these cell wall-based nanoparticles functioned as immunostimulants. Mouse macrophage RAW-blue cells were stimulated by these nanoparticles and several immunological effects were investigated. When phosphorylation of nuclear factor-κB (NF)-κB p65 subunit was increased, the expression of the inflammatory cytokines interleukin-6 and tumor necrosis factor-α were induced via NF-κB. On the other hand, Toll-like receptor 4 recognizes cell wall components of bacteria and fungi. In the present study, it was also shown that these cell wall-based nanoparticles serve an immunostimulatory role as ligands of Toll-like receptor 4 by RNA interference experiments. The results of the present study suggested that the signaling pathway of nanoparticles obtained from boiled Glycyrrhizae radix water extracts, at least partially involved TLR4 and downstream signaling from this receptor, resulting in the immunostimulatory effects of these nanoparticles in RAW-blue cells.

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Juzen-taiho-to, an Herbal Medicine, Activates and Enhances Phagocytosis in Microglia/Macrophages

Cited by 20 publications

References 37 publications

Lipopolysaccharides Derived from Pantoea agglomerans Can Promote the Phagocytic Activity of Amyloid β in Mouse Microglial Cells

Lipopolysaccharides Derived from Pantoea agglomerans Can Promote the Phagocytic Activity of Amyloid β in Mouse Microglial Cells

The Therapeutic Effects of the Herbal Medicine, Juzen-taiho-to, on Amyloid-β Burden in a Mouse Model of Alzheimer's Disease

Immunostimulatory effects of cell wall‑based nanoparticles in boiled Glycyrrhizae radix water extracts involves TLR4

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