Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice

Morita, Yasuyo; Ishida, Takanobu; Morisawa, Shumpei; Jobu, Kohei; Ou, Yangran; Fujita, Hiroko; Hanazaki, Kazuhiro; Miyamura, Mitsuhiko

doi:10.1248/bpb.b20-00555

Cited by 7 publications

(9 citation statements)

References 31 publications

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“…As for the countries where the experiments were conducted, China had the most cases (n = 20) [ 8 , 9 , 13 , 15 , 16 , 19 , 23 , 26 , 27 , 28 , 29 , 30 , 32 , 36 , 38 , 39 , 46 , 47 , 48 , 49 ], followed by Japan (n = 8) [ 12 , 20 , 40 , 41 , 42 , 43 , 44 , 45 ], Korea (n = 6) [ 24 , 31 , 33 , 34 , 35 , 37 ] and Taiwan (n = 3) [ 21 , 22 , 23 ]. Thailand [ 18 ], the United States [ 17 ], Mexico [ 11 ] and Poland [ 25 ] were each associated with one study.…”

Section: Resultsmentioning

confidence: 99%

“…In herbal medicine extraction, 17 studies used water extraction [ 9 , 13 , 14 , 17 , 20 , 21 , 22 , 27 , 31 , 33 , 39 , 40 , 42 , 45 , 47 , 48 ]; 6 studies used ethanol [ 10 , 16 , 18 , 24 , 34 , 35 ]; and 2 studies used carbon dioxide fluid [ 23 , 26 ]. Three studies used a suspension of the herbal formula Guilingji [ 15 , 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

et al. 2023

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Background: The world’s population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines. Methods: In vivo studies of single or complex herbal medicines for anti-aging that were published in the last five years were included in this review. The following databases were used: PubMed, Scopus, ScienceDirect, Web of Science and EMBASE. Results: A total of 41 studies were considered eligible for the review. The articles were classified into body organs and functions, experimental country, herbal medicine, extraction method, administration route, dosage, duration, animal model, aging-induced method, sex, number of animals per group, and outcomes and mechanisms A single herbal extract was used in a total of 21 studies including Alpinia oxyphylla Miq., Acanthopanax senticosus and Lyceum barbarum, and a multi-compound herbal prescription was used in a total of 20 studies, including Modified Qiongyu paste, Wuzi Yanzong recipe, etc. Each herbal medicine had anti-aging effects on learning and memory, cognition, emotion, internal organs, gastrointestinal tracts, sexual functions, musculoskeletal function and so on. The common mechanisms of action were antioxidant and anti-inflammatory, and various effects and mechanisms for each organ and function were identified. Conclusions: Herbal medicine exhibited beneficial effects on anti-aging in various parts of the body and its function. Further investigation of the appropriate herbal medicine prescriptions and their components is recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

et al. 2023

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“…Thereafter, reverse transcription was carried out using the PrimeScript RT reagent Kit (Takara Bio, Otsu, Japan). qRT-PCR of the mRNA in the GA samples was performed as previously described [ 25 ]. qRT-PCR was performed using the Step One Plus Real-Time PCR System (Applied Biosystems, CA, USA) and the mRNA expression levels of sirtuin1 ( sirt1 ) and ubiquitin ligases ( murf1 and atrogin1 ) were evaluated using GAPDH as the internal reference standard.…”

Section: Methodsmentioning

confidence: 99%

“…These herbal medicines include several traditional Japanese medicines that consist of a combination of several herbs. Recently, several herbal medicines have been reported to inhibit muscle atrophy [23][24][25][26] suggesting that these therapeutic compounds may act as a preventive treatment for sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Saikokeishikankyoto extract alleviates muscle atrophy in KKAy mice

Jobu

Ishida

et al. 2022

J Nat Med

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Sarcopenic obesity is associated with increased visceral fat and decreased muscle mass, resulting in decreased insulin sensitivity, increased production of inflammatory cytokines, and oxidative stress. In this study, we first evaluated the effects of herbal medicines on the transcriptional activity of the Sirtuin 1 (sirt1) promoter in vitro as an indicator of their therapeutic effect. Our data suggested that hot water Saikokeishikankyoto (SKK) extracts increased sirt1 transcriptional activity in vitro, identifying it as a candidate therapeutic for evaluation in the KKAy type 2 diabetic obesity mouse model. These in vivo evaluations revealed that SKK treatment increased the wet weight and muscle fiber content in cross sections of the gastrocnemius muscle (GA) and restored motor function in these animals. In addition, SKK treatment reduced tumor necrosis factor-α (TNFα) expression in the sera and suppressed Atrogin1 and MuRF1 transcription in the GA samples. This treatment also increased sirt1 expression in these tissues. These results suggest that SKK inhibits skeletal muscle atrophy and improves motor function in KKAy mice by suppressing inflammation. In actual clinical practice, SKK is expected to inhibit muscle atrophy and improve motor dysfunction in sarcopenic obesity. Graphical abstract

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“…Resveratrol also protects the mice against negative health consequences of a high-fat diet. Juzentaihoto, a Chinese herbal medicine, prevents muscle atrophy in senescence accelerated mouse (SAMP8) via activation of SIRT1 [83]. Bring together, all these findings suggest that SIRT1 activation plays a pivotal role in the protection against age associated sarcopenia.…”

Section: Sirtuin As a Marker/ Therapeutic Targetmentioning

confidence: 97%

The Role of Sirtuins in Sarcopenia and Frailty

Anwar¹,

Pradhan²,

Dey³

et al. 2023

Aging and disease

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The population of older individuals is increasing rapidly, but only a small fraction among them is able to experiences a healthy life. Due to lack of physical exercise and oxidative stress, aging leads to sarcopenia and finally end up with frailty. Sarcopenia is a component of the frailty and described as age related degenerative changes in the skeletal muscle mass, strength and quality. Though the loss of muscle strength and mass gradually seem inevitable during aging, it can be partially prevented or overcome by a deeper insight into the pathogenesis. Sirtuin protein leads to longevity across different organisms ranging from worms to mammals. Expression of sirtuin protein increases during physical exercise and thus strengthens muscle mass. Satellite cells leads to muscle repair in a SIRT1 dependent manner. In addition, SIRT1 improves insulin sensitivity and induces autophagy in the aged mice. The current paper discussed the putative role of sirtuins in sarcopenia and frailty. Moreover, it highlighted the pathways by which sirtuins can inhibit ROS production, inflammation and mitochondrial dysfunctions and therefore confers a protective role against frailty and sarcopenia. The critical role of sirtuins in the sarcopenia and frailty pathogenesis can eventually fuel the development of novel interventions by targeting sirtuins.

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Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice

Cited by 7 publications

References 31 publications

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

Saikokeishikankyoto extract alleviates muscle atrophy in KKAy mice

The Role of Sirtuins in Sarcopenia and Frailty

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