K-complex evoked in NREM sleep is accompanied by a slow negative potential related to cognitive process

Niiyama, Yoshitsugu; Fushimi, Masahito; Sekine, Atsushi; Hishikawa, Yasuo

doi:10.1016/0013-4694(95)00021-p

Cited by 52 publications

(52 citation statements)

References 16 publications

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“…The P450 and N550, however, were found to be indiscernible in several of our conditions. The N550 was considered to be the negative component of the K-complex and was shown to be absent or greatly reduced when the trials with K-complex were excluded from averaging Niiyama et al, 1995;Colrain et al, 1999;Gora et al, 2001). Previous studies have reported that K-complexes were not to be elicited with shorter ISIs (Bastien and Campbell, 1994;Colrain, 2005;Halasz, 2005).…”

Section: Discussionmentioning

confidence: 99%

The effects of sleep stages and time of night on NREM sleep ERPs

Yang

2007

International Journal of Psychophysiology

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Section: Discussionmentioning

confidence: 99%

The effects of sleep stages and time of night on NREM sleep ERPs

Yang

2007

International Journal of Psychophysiology

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“…There is now a substantial literature indicating that the N550 measured in KC averages in adults, has a topographic distribution indicating frontal or fronto-central maxima, bilateral symmetry, and a gradual fall off in voltage from the midline frontal/fronto-central area to the posterior and lateral scalp regions (Colrain et al, 1999; Cote et al, 1999; Niiyama et al, 1995). In adult humans, KCs thus represent a highly synchronized cortical phenomenon that has a substantial frontal predominance.…”

Section: Discussionmentioning

confidence: 99%

Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan

Colrain

Crowley²,

Nicholas

et al. 2010

Neurobiology of Aging

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Aging is associated with many changes in sleep, with one of the most prominent being a reduction in slow wave sleep. Traditional measures of this phenomenon rely on spontaneous activity and typically confound the incidence and amplitude of delta waves. The measurement of evoked K-complexes during sleep, enable separate assessment of incidence and amplitude taken from the averaged K-complex waveform. The present study describes data from 70 normal healthy men and women aged between 19 and 78 years. K-complexes were evoked using short auditory tones and recorded from a midline array of scalp sites. Significant reductions with age were seen in the amplitude of the N550 component of the averaged waveform, which represents the amplitude of the K-complex, with linear regression analysis indicating approximately 50% of the variance was due to age. Smaller, yet still significant reductions were seen in the ability to elicit K-complexes. The data highlight the utility of evoked K-complexes as a sensitive marker of brain aging in men and women.

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“…K-complexes are < 2.0 Hz-waveforms with a sharp initial negative component followed by a slower positive component (Rechtschaffen and Kales, 1968). Similar to slow waves (Finelli et al, 2001), K-complexes are maximal over the frontocentral region of the scalp (Niiyama et al, 1995; Paiva and Rosa, 1991). K-complexes are unique because they occur spontaneously and can also be evoked.…”

Section: Sleep and Arousalmentioning

confidence: 98%

Sleep and the functional connectome

2013

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Sleep and the functional connectome are research areas with considerable overlap. Neuroimaging studies of sleep based on EEG-PET and EEG-fMRI are revealing the brain networks that support sleep, as well as networks that may support the roles and processes attributed to sleep. For example, phenomena such as arousal and consciousness are substantially modulated during sleep, and one would expect this modulation to be reflected in altered network activity. In addition, recent work suggests that sleep also has a number of adaptive functions that support waking activity. Thus the study of sleep may elucidate the circuits and processes that support waking function and complement information obtained from fMRI during waking conditions. In this review, we will discuss examples of this for memory, arousal, and consciousness after providing a brief background on sleep and on studying it with fMRI.

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K-complex evoked in NREM sleep is accompanied by a slow negative potential related to cognitive process

Cited by 52 publications

References 16 publications

The effects of sleep stages and time of night on NREM sleep ERPs

The effects of sleep stages and time of night on NREM sleep ERPs

Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan

Sleep and the functional connectome

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