1995
DOI: 10.1016/0016-5085(95)90201-5
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K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas

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Cited by 48 publications
(62 citation statements)
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“…24 -27 K-ras2 mutations in colorectal adenomas were detected in both DNA diploid and aneuploid cells and in some cases in regions of histologically normal mucosa, suggesting that K-ras2 mutations occur before change in DNA ploidy. 22,23 Also, human colorectal aberrant crypt foci, suggested to be early precursor lesions of adenomas, were found to be mutated in K-ras2 up to the 85% level. 28 -30 The present study addresses the possible relationship of specific Kras2 mutations with DNA aneuploidy and proliferation in human sporadic colorectal adenomas.…”
mentioning
confidence: 99%
“…24 -27 K-ras2 mutations in colorectal adenomas were detected in both DNA diploid and aneuploid cells and in some cases in regions of histologically normal mucosa, suggesting that K-ras2 mutations occur before change in DNA ploidy. 22,23 Also, human colorectal aberrant crypt foci, suggested to be early precursor lesions of adenomas, were found to be mutated in K-ras2 up to the 85% level. 28 -30 The present study addresses the possible relationship of specific Kras2 mutations with DNA aneuploidy and proliferation in human sporadic colorectal adenomas.…”
mentioning
confidence: 99%
“…Many studies have examined the association of K-ras mutations with CRC (Bos et al, 1987;Forrester et al, 1987;Vogelstein et al, 1988;Bos, 1989;Burmer and Loeb, 1989;Vogelstein et al, 1989;Capella et al, 1991;Oudejans et al, 1991;Sidransky et al, 1992;Bell et al, 1993;Finkelstein et al, 1993a and b;McLellan et al, 1993;Urosevic et al, 1993;Breivik et al, 1994;Moerkerk et al, 1994;Morrin et al, 1994;Giaretti et al, 1995;Hasegawa et al, 1995;Hayashi et al, 1995;Ranaldi et al, 1995;Carpenter et al, 1996;Span et al, 1996;Villa et al, 1996). However, there are significant differences in reported frequencies of K-ras mutations in CRC (McLellan et al, 1993).…”
Section: Discussionmentioning
confidence: 99%
“…A significant proportion of CRCs have mutations in the K-ras oncogene (Bos et al, 1987;Forrester et al, 1987;Vogelstein et al, 1988;Burmer and Loeb, 1989;Delattre et al, 1989;Fearon and Vogelstein, 1990;Capella et al, 1991;Oudejans et al, 1991;Offerhaus et al, 1992;Bell et al, 1993;Finkelstein et al, 1993a and b;McLellan et al, 1993;Peltomaki et al, 1993;Urosevic et al, 1993;Breivik et al, 1994;Moerkerk et al, 1994;Morrin et al, 1994;Tanaka et al, 1994;Giaretti et al, 1995;Span et al, 1996). We report a study using 301 DNA samples extracted from a colorectal tumour bank.…”
mentioning
confidence: 94%
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