K
ATP
channel–dependent electrical signaling links capillary pericytes to arterioles during neurovascular coupling
Dominic Isaacs,
Liuruimin Xiang,
Ashwini Hariharan
et al.
Abstract:The brain has evolved mechanisms to dynamically modify blood flow, enabling the timely delivery of energy substrates in response to local metabolic demands. Several such neurovascular coupling (NVC) mechanisms have been identified, but the vascular signal transduction and transmission mechanisms that enable dilation of penetrating arterioles (PAs) remote from sites of increased neuronal activity are unclear. Given the exponential relationship between vessel diameter and blood flow, tight control of arteriole m… Show more
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