In this study, it is aimed to determine the levels of self-alienation and burnout among housewives in the context of gender perceptions. In this context, the study was carried out with descriptive, cross-sectional and relational design. The study was conducted with 368 housewives living in Turkey. Personal information form, gender perception scale (GPS), self-alienation scale (SAS) and housewives burnout scale (CUBAC) were used to data collection. In the analysis of the data, SPSS package program was used and descriptive statistics were made with Linear Regression. In line with the analyzes, it was determined that the mean age of the women was 40.53±10.14, the mean number of children was 2.25±1.62, and the mean private time allotted to herself in a day was 2.08±2.01. In addtion, it was found that 65% of women got married in traditional way, 32% of women was only responsibile person in home for housework, 34% of women need psychological support, and 33% of women define theirselves as responsible. According to the findings, the mean score of GPS was 95.61±16.12, CUBAC was 54.68±14.28, and SAS was 69.19±10.65. It has been determined that the gender perceptions of housewives are directly related to their burnout and self-alienation levels. It was determined that these women experienced severe burnout and self-alienation especially as a result of their gender perceptions due to the expectations in the society they lived in.