Kadukkai maathirai (a polyherbal traditional siddha formulation) prevents D-galactosamine induced hepatic necrosis in rats

Shetty, Manjunath S; Shenoy, Smita; Kumar, Nitesh; Devi, V. Gayathri; Amuthan, L Arul; Shenoy, Ganesh K; Pavithra, P

doi:10.56042/ijtk.v19i4.44506

“…Figure 1 and Figure 2 illustrate the hepatotoxins utilised in the experiments to induce liver dysfunction in animal models, as well as the frequency with which each hepatotoxin was used. They include CCl 4 (Ahmad et al 2020;Arsul, Wagh & Mayee 2011;Balkrishna, Lochab & Varshney 2022;Bera et al 2012;Gurusamy et al 2010;Nipanikar, Chitlange & Nagore 2017;Said et al 2022;Sarhadynejad et al 2016;Yogi & Mishra 2017), thioacetamide (Balkrishna et al 2022), hydrogen peroxide (H 2 O 2 ) (Ndefo et al 2021), gentamicin (Aziz et al 2017), methotrexate (MTX) (Anila et al 2015), cadmium chloride (CdCl 2 ) (Singh et al 2023), D-galactosamine (Khan et al 2015;Sachdeva, Bajpai & Razdan 2013;Shetty et al 2020), alcohol (Dey et al 2020;Kanchana & Jayapriya 2013;Nipanikar et al 2017;Rafi Reshi et al 2022;Shetty et al 2018), cisplatin , isoniazid (INH) (Sankar, Rajkumar & Sridhar 2015), acetaminophen (Ali et al 2014;Fiaz et al 2017;Gupta et al 2013;Mayuren et al 2010;Nipanikar et al 2017;Patel et al 2013;Ray, Taraphdar & Gupta 2022;Saroj, Mani & Mishra 2012;Sen et al 2015;Shakya 2011;Shrivastava & Garg 2015;…”

Section: Review Findings and Discussionmentioning

confidence: 99%

“…Furthermore, they inhibit the accumulation of extracellular matrix proteins such as collagen, reducing fibrosis (Sivakumar et al 2014). Notable examples of such antiinflammatory prowess can be found in formulations such as KM and Livshis, which have demonstrated the ability to reduce proinflammatory cytokine levels and thus prevent inflammation-induced hepatic damage (Bera et al 2011;Shetty et al 2020).…”

Section: Antiinflammatory and Antifibrotic Effectsmentioning

confidence: 99%

“…Polyherbal medicines can be found in various forms, including teas, tinctures, capsules and topical preparations, and are often customised based on individual needs and symptoms. These formulations have been traditionally used in various cultures for the management of liver diseases, and recent studies have shown promising results in their hepatoprotective effects, with negligible side effects (Iroanya, Adebesin & Okpuzor 2014;Padmanabhan & Jangle 2014;Shetty et al 2018Shetty et al , 2020. They have been found to contain a variety of bioactive compounds such as flavonoids, alkaloids and terpenoids, which exhibit various pharmacological activities such as antioxidant, antiinflammatory and hepatoprotective effects (Ghayas, Hannan & Rizwani 2022).…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective activities of polyherbal formulations: A systematic review

Aladejana,

Aladejana

2023

Journal of Medicinal Plants for Economic Development

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Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human health. Hepatoprotective agents play a pivotal role in mitigating liver damage caused by chemicals, drugs and toxins. Polyherbal formulations, combining botanical components from traditional medicine, offer a promising approach to addressing liver disorders. Their popularity arises from a multi-targeted strategy in treating complex diseases, marking a shift in focus toward these formulations.Aim: The study aimed to conduct a thorough review of the existing literature on the hepatoprotective activity of polyherbal formulations and provide a comprehensive overview of their mechanisms of action. This review provides the overview of the use of polyherbal formulations in the management of liver disease.Method: A systematic search of electronic databases, including : Scopus, Academia, Elsevier, Science Direct, Wiley, BioMed Central, PubMed, and Google Scholar, was conducted using a combination of keywords such as ‘polyherbal formulations’, ‘hepatoprotective’ and ‘liver diseases’. Studies published between January 2010 and April 2023 were included in the review.Results: A total of 61 articles were reviewed, and the studies showed that polyherbal formulations possess significant hepatoprotective activity against various hepatotoxic agents. The mechanisms of action of these formulations include antioxidant, antiinflammatory, antifibrotic and antiapoptotic effects. Additionally, some polyherbal formulations were found to stimulate liver regeneration, enhance bile secretion and promote detoxification processes.Conclusion: Polyherbal formulations have shown promising hepatoprotective activity, and their multitargeted approach to treating complex diseases makes them a potential alternative to conventional medicines. However, identifying the active compounds responsible for the hepatoprotective effects of these formulations and their pharmacokinetics and pharmacodynamics could provide insights into the development of new and effective drugs for liver disorders.Contribution: This article contributes to the growing body of literature on the potential of polyherbal formulations as hepatoprotective agents.

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Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study

Shetty,

Shenoy,

Amuthan

et al. 2024

F1000Res

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Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor clinical outcomes. Hence cost-effective drugs with fewer side effects as a standard supportive therapy might yield substantial advantages in efficacy and safety. Kadukkai maathirai (KM) is being used as a supplement in hepatocellular carcinoma. We evaluated whether KM has any preventive action on cancer progression in diethyl nitrosamine (DEN) - induced HCC in rats. Methods DEN was injected to produce HCC in rats, which was confirmed after 16 weeks. All the rats were orally administered KM for 4 weeks. Hepatoprotective potential (serum AST, ALT, ALP, Bilirubin) and anticancer efficacy (body weight, nodule count, tumor progression by histopathology, expression of GSTM1 by Liquid chromatography-mass spectrometry (LC-MS), and In-silico analysis of phytoconstituents against β catenin and LRP analysis were evaluated. Results KM prevented cancer progression against DEN-induced HCC by an increase in GSTM1, a phase II detoxifying enzyme. It significantly reversed altered nodule count, relative liver weight, body weight, and histopathological features of HCC. In silico analysis of phytoconstituents of KM showed that they modulate the intracellular transcription process by inhibiting the armadillo repeat region of β catenin. Conclusions Our results elucidate the potential of KM as a supplement in HCC by reducing nodule count, protecting the liver from further damage, GSTM1 expression, and inhibiting armadillo repeat region of β catenin.

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Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study

Shetty,

Shenoy,

Amuthan

et al. 2024

F1000Res

0

View full text Add to dashboard Cite

Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor clinical outcomes. Hence cost-effective drugs with fewer side effects as a standard supportive therapy might yield substantial advantages in efficacy and safety. Kadukkai maathirai (KM) is being used as a supplement in hepatocellular carcinoma. We evaluated whether KM has any preventive action on cancer progression in diethyl nitrosamine (DEN) - induced HCC in rats. Methods DEN was injected to produce HCC in rats, which was confirmed after 16 weeks. All the rats were orally administered KM for 4 weeks. Hepatoprotective potential (serum AST, ALT, ALP, Bilirubin) and anticancer efficacy (body weight, nodule count, tumor progression by histopathology, expression of GSTM1 by Liquid chromatography-mass spectrometry (LC-MS), and In-silico analysis of phytoconstituents against β catenin and LRP analysis were evaluated. Results KM prevented cancer progression against DEN-induced HCC by an increase in GSTM1, a phase II detoxifying enzyme. It significantly reversed altered nodule count, relative liver weight, body weight, and histopathological features of HCC. In silico analysis of phytoconstituents of KM showed that they modulate the intracellular transcription process by inhibiting the armadillo repeat region of β catenin. Conclusions Our results elucidate the potential of KM as a supplement in HCC by reducing nodule count, protecting the liver from further damage, GSTM1 expression, and inhibiting armadillo repeat region of β catenin.

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Kadukkai maathirai (a polyherbal traditional siddha formulation) prevents D-galactosamine induced hepatic necrosis in rats

Cited by 3 publications

References 2 publications

Hepatoprotective activities of polyherbal formulations: A systematic review

Hepatoprotective activities of polyherbal formulations: A systematic review

Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study

Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study

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