Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner

Xu, Wen; Liu, Jianwen; Li, Changlong; H, Wu

doi:10.1016/j.canlet.2008.01.044

Cited by 91 publications

(50 citation statements)

References 32 publications

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“…Two widely distributed flavonols, fisetin and quercetin are able also to suppress the migration and invasion of human cervical tumor cells providing some insights on the use of these compounds as potential antimetastatic agents in cancer chemotherapy (Bishayee et al, 2013;Chou et al, 2013). Differently from some flavones described above, introduction of sugar moiety into the structure of flavonol kaempferol does not seem to result in any remarkable decrease in its cytotoxic activity as both kaempferol-7-O-β-D-glucoside and kaempferitrin display important time-and dose-dependent anticancer activity in human cervix carcinoma HeLa cells (Xu et al, 2008;AlonsoCastro et al, 2013).…”

Section: Flavonolsmentioning

confidence: 99%

“…Also, the clinical use of current treatment modalities is often hampered by severe side effects and toxicity to normal tissues (Xu et al, 2008;Xu et al, 2011;Singh et al, 2013). Therefore, considering the high incidence and mortality rate of cervical cancer worldwide novel treatment strategies are urgently required Xu et al, 2008;Singh et al, 2013).…”

Section: Sensitization Of Cervical Cancer Cells To Chemo-and/or Radiomentioning

confidence: 99%

“…The common dietary licorice chalcone isoliquiritigenin has shown to reduce the cell viability by inducing cell cycle arrest and morphological and biochemical features of apoptosis in both HPV16-(CaSki, SiHa) and HPV18-positive (HeLa) cell lines as well as HPV-negative cervical cancer cells (C33A) (Li et al, 2008;Hsu et al, 2009;Park et al, 2009;Hirchaud et al, 2013). Increase in intracellular reactive oxygen species (ROS) and triggering oxidative stress may play a critical role in isoliquiritigenin induced HeLa cell apoptosis (Yuan X et al, 2012;Yuan et al, 2013).…”

Section: Chalconesmentioning

confidence: 99%

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Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.

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Section: Flavonolsmentioning

confidence: 99%

Section: Sensitization Of Cervical Cancer Cells To Chemo-and/or Radiomentioning

confidence: 99%

Section: Chalconesmentioning

confidence: 99%

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Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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“…Os efeitos antioxidantes desta espécie são atribuídos aos flavonóides identificados, que podem ser indicadores do controle de qualidade desta planta como a isoramnetina, camferol e quercetina (Rugna et al, 1999;Rugna et al, 2004;Rugna et al, 2007;Shao et al, 2007;Rugna et al, 2008;Xu et al, 2008).…”

Section: Echinodorus Grandiflorus Bauhinia Forficata Tabebuia Avellunclassified

“…Modelos in vitro de vários tipos de cultura celular têm sido utilizados por grandes laboratórios de pesquisas e indústrias farmacêuticas para comprovar, a nível molecular, o mecanismo de ação pelos quais os flavonóides são eficazes em reduzir a concentração de colesterol do sangue Whitman et al, 2005;Brusq et al, 2006). A fitoterapia é modalidade de tratamento que vem crescendo nos últimos anos, principalmente em função do alto custo dos medicamentos industrializados (Yunes et al, 2001). Apesar de muito usada como alternativa para os tratamentos de doenças como câncer, aterosclerose, diabetes, hipertensão, dentre outras, pesquisas científicas devem ser feitas sobre a atividade farmacológica das plantas bem como os efeitos tóxicos (Singi et al, 2005).…”

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Plantas com possível atividade hipolipidêmica: uma revisão bibliográfica de livros editados no Brasil entre 1998 e 2008

Pizziolo

Brasileiro

Oliveira

et al. 2011

Rev. bras. plantas med.

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RESUMO:O objetivo deste trabalho foi realizar levantamento sobre as plantas medicinais indicadas para o tratamento da hiperlipidemia, hipercolesterolemia e/ou aterosclerose. Este estudo foi feito a partir da pesquisa bibliográfica em 32 livros publicados no Brasil entre 1998 e 2008, resultando em lista de 85 espécies distribuídas em 53 famílias, principalmente Asteraceae e Fabaceae, com 54 espécies exóticas e 31 nativas. As espécies mais citadas foram Allium sativum (Alliaceae), Cynara scolymus (Asteraceae), Curcuma longa (Zingiberaceae), Allium cepa (Alliaceae), Echinodorus grandiflorus (Alismataceae), Taraxacum officinale (Asteraceae), Vernonia condensata (Asteraceae), Cuphea carthagenensis (Lythraceae) e Curcuma zedoaria (Zingiberaceae). As espécies nativas, citadas em pelo menos 2 livros, foram investigadas para alguma evidencia científica relacionada a possíveis efeitos hipolipidêmico, hipocolesterolêmico e/ou contra aterosclerose. Somente foram encontrados estudos científicos, relacionados a estes efeitos, para as espécies nativas Cuphea carthagenensis e Echinodorus grandiflorum, indicando a necessidade de pesquisas que possam garantir a segurança e a eficácia do uso destas espécies.Palavras-chave: aterosclerose, hipercolesterolemia, hiperlipidemia, plantas medicinais ABSTRACT: Plants with possible hypolipidemic activity: a review of books published in Brazil between 1998 and 2008. The aim of this study was to survey medicinal plants indicated for the treatment of hyperlipidemia, hypercholesterolemia and/or atherosclerosis. This study was performed from a review of 32 books published in Brazil between 1998 and 2008, resulting in a list of 85 species belonging to 53 families, especially Asteraceae and Fabaceae, with 54 exotic and 31 native species. The species most often cited were Allium sativum (Alliaceae), Cynara scolymus (Asteraceae), Curcuma longa (Zingiberaceae), Allium cepa (Alliaceae), Echinodorus grandiflorus (Alismataceae), Taraxacum officinale (Asteraceae), Vernonia condensata (Asteraceae), Cuphea carthagenensis (Lythraceae) and Curcuma zedoaria (Zingiberaceae). Native species cited in at least 2 books were investigated for some scientific evidence related to possible hypolipidemic and hypocholesterolemic effects and/or action against atherosclerosis. Scientific studies related to these effects were found only for the native species Cuphea carthagenensis and Echinodorus grandiflorum, indicating the need for studies capable of assuring the safety and the efficacy as to the use of these species.Key words: atherosclerosis, hypercholesterolemia, hyperlipidemia, medicinal plants INTRODUÇÃOOs últimos 30 anos tem presenciado um declínio razoável da mortalidade por causas cardiovasculares em países desenvolvidos, enquanto que elevações rápidas e substanciais tem ocorrido em países em desenvolvimento, dentre eles o Brasil. De acordo com a OMS, esta tendência de aumento na doença cardiovascular tende a persistir, agravando ainda mais o quadro de morbidade e mortalidade elevadas nos países em desenvolviment...

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Inhibition of IGF‐IR increases chemosensitivity in human colorectal cancer cells through MRP‐2 promoter suppression

Shen

Cui

Sun

et al. 2012

J of Cellular Biochemistry

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The emergence of multidrug resistance (MDR) in cancer cells has made many of the currently available chemotherapeutic agents ineffective. However, the mechanism involved in mediating this effect is not yet fully understood. Here, we found the overexpression of type I insulin‐like growth factor receptor (IGF‐IR) in established colorectal MDR cells. Specific siRNA of IGF‐IR decreases cell proliferation, exert synergistic effect with anticancer drugs. The downstream signaling of IGF‐IR, PI3K/AKT pathway, was altered upon IGF‐IR silencing. The expression of multidrug‐resistance‐associated protein 2 (MRP‐2) was suppressed due to the nuclear translocation of nuclear factor‐like 2 (Nrf2). Then the intracellular drug concentration was increased and the drug‐resistant phenotype was reversed. Our findings improve current understanding of the biology of IGF‐IR and MDR and have significant therapeutic implications on colorectal MDR cancer. J. Cell. Biochem. 113: 2086–2097, 2012. © 2012 Wiley Periodicals, Inc.

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Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner

Cited by 91 publications

References 32 publications

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Plantas com possível atividade hipolipidêmica: uma revisão bibliográfica de livros editados no Brasil entre 1998 e 2008

Inhibition of IGF‐IR increases chemosensitivity in human colorectal cancer cells through MRP‐2 promoter suppression

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