2023
DOI: 10.1016/j.phymed.2022.154246
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Kaempferol inhibits renal fibrosis by suppression of the sonic hedgehog signaling pathway

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Cited by 15 publications
(8 citation statements)
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“…Specifically, abnormal hedgehog signaling pathway activation activates hepatic stellate cells to activate mRNAs (like Shh, Ptch 1, Gli 1, and Smo) and inhibit apoptosis [27]. In addition, the hedgehog pathway is activated when renal fibrosis occurs in the body, significantly increasing the key component expression in the signaling pathway, thereby further promoting renal fibrosis [28]. In short, the hedgehog signaling pathway is notably correlated with fibrosis in the lung, kidney, liver, and other organs.…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, abnormal hedgehog signaling pathway activation activates hepatic stellate cells to activate mRNAs (like Shh, Ptch 1, Gli 1, and Smo) and inhibit apoptosis [27]. In addition, the hedgehog pathway is activated when renal fibrosis occurs in the body, significantly increasing the key component expression in the signaling pathway, thereby further promoting renal fibrosis [28]. In short, the hedgehog signaling pathway is notably correlated with fibrosis in the lung, kidney, liver, and other organs.…”
Section: Discussionmentioning
confidence: 99%
“…Kaempferol and baicalein have been proven to play antifibrotic roles. [ 29 ] The common ingredient β-sitosterol (MOL000358) in PKSH also played a role in the treatment of liver fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Han et al demonstrated that rutin prevents fibrosis progression in CKD [20]. Kaempferol (KAE) is a plant-derived flavonoid that controls renal fibrosis progression and the EMT in the renal tubular system [21]. Meanwhile, KAE attenuates renal injury and reverses phenotypic transformation and collagen accumulation in renal tubular epithelial cells [22].…”
Section: Qsg Chemical Constituent Analysis In Vitromentioning
confidence: 99%