Community-based Sanitation (SANIMAS) is an activity to address sanitation problems in Indonesia. 88% of communities in Temanggung Regency dispose of domestic wastewater directly into the river without any prior treatment. As an effort to protect the environment, the SANIMAS program was developed with the Local Domestic Waste Management System (SPALDS). The objective is to identify the relationship between factors influencing community participation and the sustainability of the SANIMAS program. Factors influencing community participation are technological, institutional, financial and economic, socio-cultural, and environmental. Community participation is determined based on the SANIMAS program stages, namely input, process, and output as well as the sustainability of the SANIMAS program. This research uses the quantitative method of Partial Least Squares - Structural Equation Modeling (PLS-SEM) with Smart PLS version 3.0. The results of this study indicate that technological, institutional, financial and economic, and socio-cultural factors have a positive effect on community participation and sustainability. Technological, institutional, and socio-cultural factors have a significant effect on community participation and sustainability with T-statistic values 2.659, 2.136, and 2.73 and P-values 0.008, 0.033, and 0.007. These factors affect the positive and significant correlation of community participation to the sustainability of the SANIMAS program.