The condition of COVID-19 pandemic led to a high generation of medical waste through hospital activity. This study aimed to analye the hazardous waste management during the pandemic at Hospital A in Yogyakarta. Dynamic system modelling applications by considering the technical, financial, and environmental aspects using the Vensim PLE with the stock-flow diagram. The model simulation results in this study indicate an increase in technical, financial, and environmental aspects during the pandemic. The technical and financial aspect shows that the generation and transportation of waste increased during the pandemic reaching 9.36%. In the technical aspect, hazardous waste generation produced 11,756 kg/year. Then, the financial aspect shows that the costs incurred for transporting waste increased during the pandemic, reaching IDR109,860,000/year. The financial aspect also indicates that the fees received by hospital A in Yogyakarta from recycling waste increased until IDR3,232,900/year. The environmental aspect shows that CO2 emissions released into the air due to the transportation of waste during the pandemic experienced a stable condition, it is 5,445.44 kgCO2 per year, and CO2 emissions stored due to the recycling of plastic infusion bottle waste increased by 4,021.73 kgCO2 per year.