Kamikihito, a traditional Japanese Kampo medicine, increases the secretion of oxytocin in rats with acute stress

Tsukada, M.; Ikemoto, Hideshi; Lee, Xiao‐Pen; Takaki, Takashi; Tsuchiya, Naho; Mizuno, Keita; Inoue, Tatsuki; Tsunokawa, Yoshiki; Okumo, Takayuki; Matsuyama, Taka‐aki; Sunagawa, Makoto

doi:10.1016/j.jep.2021.114218

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…Kampo prescription has the effect of enhancing the body's natural healing power. Kamikihito, prescribed in case 1, consists of 14 crude drugs ( 32 ) and is a Kampo prescription known to be effective in treating insomnia, anorexia, and depression ( 33 ). Ninjin'yoeito, prescribed in case 2, consists of 12 crude drugs and is used for recovery from decreased physical strength after illness or surgery and improvement of symptoms such as fatigue, anorexia ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Acupuncture is an effective treatment for olfactory dysfunction in the post COVID-19 condition

et al. 2022

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Olfactory dysfunction in the post COVID-19 condition reported worldwide are refractory for some patients. For this reason, appropriate treatment is desired. In this article, we describe two cases of olfactory dysfunction in the post COVID-19 condition that was improved by traditional acupuncture treatment. By using the Yingxiang point (LI20), which is said to improve the sense of smell since ancient times, acupuncture treatment was performed 1–2 times a week in two patients about 6 and 7 months after the diagnosis of COVID-19. Acupuncture needles with a body length of 30 mm and a body diameter of 0.16 mm were inserted about 10 mm deep into the skin. We stimulated LI20 of the right and left sides until the patients felt the de qi sensation (acupuncture resonance), and left needles in the points for about 15 min. Immediately after the acupuncture treatment, the symptoms of olfactory dysfunction were alleviated, and the improvement in olfactory dysfunction lasted for 2–4 days. As the number of acupuncture treatments increased, the time until the flareup of olfactory dysfunction was prolonged, and the symptoms tended to decrease. In our experience, the acupuncture treatment was effective in a short period for treating residual olfactory dysfunction of the post COVID-19 condition, suggesting that acupuncture may serve as an adjunct to modern medical treatment, and it may also be a new option for patients who are resistant to Western medical treatment or unable to continue treatment because of side effects. In conclusion, acupuncture may be a new option for patients who are resistant to modern medical treatment or who are unable to continue treatment because of side effects.

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Section: Discussionmentioning

confidence: 99%

Case Report: Acupuncture is an effective treatment for olfactory dysfunction in the post COVID-19 condition

et al. 2022

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“… Tsukada et al (2021) reported that ACTH and CORT levels of KKT-administrated rats slightly increased in the acute immobilization stress (AIS) group compared with those in the control group. This is a different result of the nociceptive response than in the present experiment.…”

Section: Discussionmentioning

confidence: 99%

“…There was a significant difference in plasma CORT concentrations between males and females in both the control and KKT pre-treated groups (Figure 2). Tsukada et al (2021) reported that ACTH and CORT levels of KKT-administrated rats slightly increased in the acute immobilization stress (AIS) group compared with those in the control group. This is a different result of the nociceptive response than in the present experiment.…”

Section: Figurementioning

confidence: 99%

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Expression of oxytocin in hypothalamus and reduction of nociceptive stress following administration of Kamikihi-to in female rats

et al. 2022

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Hypothalamo-neurohypophysial oxytocin (OXT) plays an essential role in reproduction and in several socio-physiological functions, including stress reduction, anxiety relief, feeding suppression, social recognition, and trust building. Recent studies suggest that the central OXT system is also involved in antinociceptive and anti-inflammatory functions. Kamikihi-to (KKT), a Japanese traditional herbal (Kampo) medicine composed of 14 herbal ingredients, is clinically prescribed for patients with psychological symptoms, including anxiety, depression, and insomnia, and it has been associated with OXT expression. We investigated the antinociceptive response and OXT expression according to sex and the effects of KKT pre administration in a rat model. We found that nociceptive responses measured via the hot plate and formalin tests were attenuated following the administration of KKT-enriched feed for 4 weeks. The observation of mRFP1 fluorescence in OXT-mRFP1 transgenic rats revealed that KKT-administered rats showed increased expression of OXT in the magnocellular and parvocellular paraventricular nucleus of the hypothalamus. Food intake in the KKT-pre-administered group significantly decreased after cholecystokinin (CCK)-8 administration. Our results suggest that KKT is involved in the attenuation of nociceptive stress in female rats by enhancing the expression of OXT in the hypothalamus.

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“…The method of intracerebroventricular naltrindole administration was modified from a previous report. 19 In brief, all rats were deeply anesthetized intraperitoneally with a combination of three anesthetics (medetomidine hydrochloride, midazolam, and butorphanol), and an injection cannula (EIM-143, Eicom, Kyoto, Japan) was inserted into the lateral ventricle (at the coordinates of AP = À0.8 mm; ML = +1.8 mm; DV = +3.5 mm from the bregma). Naltrindole (0.1 μg/rat) was intracerebroventricularly administered after the recovery period (7 days).…”

Section: Intracerebroventricular Naltrindole Administrationmentioning

confidence: 99%

Duration of the preemptive analgesic effects of low‐ and high‐frequency transcutaneous electrical nerve stimulation in rats with acute inflammatory pain

Ikemoto,

Adachi,

Okumo

et al. 2024

The Kaohsiung J of Med Scie

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Transcutaneous electrical nerve stimulation (TENS) activates various pathways to induce antinociceptive effects, based on the frequencies used. This study evaluates the preemptive analgesic effects and their duration of low‐ (LT: 4 Hz) and high‐frequency TENS (HT: 100 Hz) using a rat model of acute inflammatory pain. Acute inflammation was induced by injecting 1% formalin into the hind paws of rats. LT or HT was applied for 30 min before formalin injection. Pain‐related behaviors, such as licking, flinching, and lifting, were recorded for 60 min postinjection. Immunohistochemistry was used to assess the number of phosphorylated extracellular signal‐regulated kinase (pERK)‐ and c‐fos‐positive cells in the spinal cord. Naloxone, a μ‐opioid receptors (MORs) antagonist, and naltrindole, a δ‐opioid receptors (DORs) antagonist, were administered before TENS application. Pain behavior duration and pERK‐ and c‐fos‐positive cell expression were then measured. LT and HT pretreatment significantly reduced both pain behaviors and the number of pERK‐ and c‐fos‐positive cells postformalin injection. Naloxone and naltrindole partially reversed the effects of LT and HT, respectively. Notably, HT's analgesic effect lasted up to 120 min whereas that of LT persisted for 90 min. LT and HT effectively exerted their preemptive analgesic effects on acute inflammatory pain by inhibiting pERK and c‐fos expression in the spinal cord. HT presented a longer‐lasting effect compared to LT. MOR and DOR activation may contribute to LT and HT's analgesic mechanisms, respectively.

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Kamikihito, a traditional Japanese Kampo medicine, increases the secretion of oxytocin in rats with acute stress

Cited by 15 publications

References 36 publications

Case Report: Acupuncture is an effective treatment for olfactory dysfunction in the post COVID-19 condition

Case Report: Acupuncture is an effective treatment for olfactory dysfunction in the post COVID-19 condition

Expression of oxytocin in hypothalamus and reduction of nociceptive stress following administration of Kamikihi-to in female rats

Duration of the preemptive analgesic effects of low‐ and high‐frequency transcutaneous electrical nerve stimulation in rats with acute inflammatory pain

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