Kampo medicine “Dai-kenchu-to” prevents CPT-11-induced small-intestinal injury in rats

Abstract

DKT suppressed CPT-11 induced inflammatory cytokines and apoptosis in the intestinal mucosa and maintained the mucosal integrity.

TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression

“…A prior study had shown that small intestinal damage induced by the drug CPT-11 is also inhibited by TU-100 [43]. Whether TU-100 can be used to treat other small bowel inflammatory diseases such as viral enteritis or Celiac disease remains to be determined.…”

TU-100 exerts a protective effect against bacterial translocation by maintaining the tight junction

“…Thus, another combination treatment, which can block the cytotoxic effects of CPT-11 on normal cells, but not in tumor cells, should be sought. Various in vivo studies in animals and clinical trials in humans have reported that TU-100 shows multiple functions, including the downregulation of inflammatory mediators, with negligible side effects [13]. We therefore hypothesized that the addition of TU-100 Fig.…”

Effect of Daikenchuto, a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Trial

“…These include: anti-inflammatory properties through the selective inhibition of cyclooxygenase-2 (COX-2) 8) and/or down-regulation of several inflammatory mediators such as tumor necrosis factor-α, interleukin-1b and endothelin-1; prevention of bacterial translocation 9,10) ; and increased gastrointestinal blood flow through the induction of calcitonin gene-related peptide (CGRP), substance P, and vasoactive intestinal polypeptide (VIP) 11,12) .…”