Kaposiʼs Sarcoma: A Clinicopathologic Study With Particular Reference to Its Relationship to the Reticuloendothelial System

Reynolds, W. Ann; Winkelmann, R K; Soule, Edward H.

doi:10.1097/00005792-196509000-00003

Cited by 215 publications

(80 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These should be considered immunosuppressive, iatrogenic variants of KS described to be associated to several condition^,^^-^^ mainly to renal transplantation. l 4 The microscopic analysis of our cases emphasizes the remarkable tendency of the classic form of KS to remain localized within the dermis, its low mitotic index, and the exceptional occurrence of necrosis and anaplasia. These features, together with the bland clinical behavior and the forms of distribution and dissemination, make this a peculiar mesenchymal tumor of an extremely low grade of malignancy.…”

Section: Discussionmentioning

confidence: 66%

Kaposi's sarcoma in Colombia

Madrid

Olivella

Valderrama

et al. 1989

Cancer

View full text Add to dashboard Cite

Seventy-nine cases of Kaposi's sarcoma (KS), which correspond to one of every 1000 malignant tumors, were reviewed at the National Institute of Cancer (NIC), Bogota, Colombia, from 1935 to 1985. Seventyfour percent of the patients were older than 65 years of age. The male to female ratio was 8:l. In all cases, plaques and nodules first appeared in the lower limbs; they were symmetrical in 47% of the cases and ulcerated in 25%. No generalized or epidemic forms were seen. Esophageal squamous cell carcinoma concurrent with K S was observed in one case. KS developed several years after treatment for follicular lymphoma and chronic lymphocytic leukemia in two patients. An angiosarcomatous variant and one fibrosarcomatous change were seen. Ten cases studied for factor VIII expression through the peroxidaseantiperoxidase (PAP) technique were all reactive. We conclude that in Colombia before 1985, KS behaved as a chronic multicentric Stage I disease without a tendency to associate simultaneously with malignant conditions.

show abstract

Section: Discussionmentioning

confidence: 66%

Kaposi's sarcoma in Colombia

Madrid

Olivella

Valderrama

et al. 1989

Cancer

View full text Add to dashboard Cite

show abstract

“…The involvement of genitalia have been described in patients having generalized Kaposi sarcoma, but exclusive involvement of genitalia is rare. 2,3 In our patient, the primary site of involvement was the skin of the scrotum with subsequent involvement of the shaft of the penis. No further lesions were noticed on other parts of the body.…”

Section: Discussionmentioning

confidence: 70%

Localized Genital Kaposi Sarcoma

Govalkar

Wangnoo

1994

Annals of Saudi Medicine

View full text Add to dashboard Cite

Kapoi sarcoma is a neoplasm of multifocal origin that may involve skin as well as the viscera. It can involve skin of any part of the body, but exclusive involvement of genitalia alone is uncommon. It can occur as a sporadic, endemic or in association with HIV and non-HIV induced immunosuppression. A case of Kaposi sarcoma localized to genitalia is presented herein. To the best of our knowledge, it appears to be the first case reported from Saudi Arabia. Case ReportA 75-year-old male with diabetes mellitus (Type II NIDDM) on diet control was hospitalized for the complaints of loss of appetite and generalized weakness with a 12 week history of reddish nodules over the genitalia. There was no history of abdominal pain, loose motions, hematemesis or melena. He denied any risk factors for HIV infection or use of immunosuppressive drugs. Physical examination revealed pallor and dependent edema of both lower legs. There was no lymphadenopathy or organomegaly. Cardiovascular, respiratory and central nervous system examination revealed no abnormalities. Local examination of genitalia showed 12 reddish brown nodules and plaques involving the scrotum and shaft of the penis (Figure 1). A clinical suspicion of Kaposi sarcoma was confirmed by the histopathological study (Figure 2) of one of the nodules over the scrotum. It showed aggregated spindle-shaped cells and vascular spaces in the entire dermis. Vascular spaces were lined by plump endothelial cells and did not contain RBCs. The spindle cells were arranged in bundles. In between the spindle cells, extravasated RBCs and brownish granular hemosiderin pigment were seen. The epidermis did not show any remarkable changes. Laboratory data were as follows: microcytic hypochromic anemia (Hb levels varying between 7 to 9 g/dL), hematocrit values 28% to 35%, WBC count varying between 12,500/mm3 to 18,600 mm3, lymphocytes 5% to 15% and ESR 138 mm/hr (Westergren method). Coombs' test was negative. Routine urinalysis showed many pus cells and RBCs. Urine culture isolated different organisms on various occasions (E. coli, Klebsiella pneumoniae, Proteus mirabilis and Citrobacter diversus). Stool analysis showed no parasite or occult blood. Serological tests for HIV infection, HBsAg and syphilis were negative. Blood sugars, liver function test and serum electrolytes were within normal limits. Other biochemical indices were as follows: BUN 70 mg/dL, serum creatinine 2.5 mg/dL, total serum proteins 4.6 g/dL and 24-hour urinary proteins 0.06 g/day. Chest x-ray and skeletal survey were within normal limits. Upper GI tract endoscopy and barium studies could not be performed because of poor general condition of the patient. Ultrasound of the abdomen revealed free fluid in the abdomen. Diagnostic tapping of the abdomen revealed turbid yellowish fluid. Cytochemical analysis showed mesoepithelial cells, 0 to 4 pus cells/hpf, absence of bacteria and malignant cells and protein levels of 0.497 g/dL. CT scan of the chest and abdomen showed no significant findings except free fluid in the abdomen....

show abstract

“…Yet classical KS itself manifests at least three subtypes (Hood et al, 1982). The betterknown cutaneous variant runs a protracted course and those affected usually die of unrelated causes (Reynolds et al, 1962;Safai & Good, 1981) with an average survival of 8-13 years after diagnosis (Rothman, 1962). The nodular form of the disease is characterised by locally aggressive lesions which may appear as fungating, exophytic, ulcerating growths or as a diffuse infiltrative process involving large areas of skin and subcutaneous tissue, with bone involvement common.…”

Section: Discussionmentioning

confidence: 99%