Kaposi's sarcoma and cytomegaloviral ileocolitis complicating long-standing Crohn's disease in an HIV-negative patient

Cohen, R L; Tepper, Robert; Urmacher, Carlos; Katz, Seymour

doi:10.1111/j.1572-0241.2001.04676.x

Cited by 15 publications

(3 citation statements)

References 22 publications

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“…Apart from the above speculations, it has been proposed that, in IBD patients on chronic immunosuppression, it is important to consider opportunistic infections and concomitant neoplasms 24. It should also be mentioned that CMV could induce immunologic disorders such as ulcerative colitis that may culminate in increased susceptibility of the involved tissue to malignant degeneration 25.…”

Section: Discussionmentioning

confidence: 99%

Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease

Dimitroulia

Spanakis

Konstantinidou

et al. 2006

Inflammatory Bowel Diseases

118

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Patients with ulcerative colitis had more often detectable CMV genome in their blood as well as in their intestinal tissue samples as compared with controls (P = 0.022 and P < 0.0001, respectively). However, patients with Crohn's disease had more often detectable CMV genome only in their intestinal tissue samples as compared with controls (P = 0.001). Detection of CMV genome in blood or intestinal tissue was significantly associated with short duration of IBD (P = 0.0088 and 0.04, respectively) but not with age, sex, severity of the disease, activity at colonoscopy, pancolitis, administration of a specific treatment, and surgery. In this cross-sectional prospective study, detection of CMV genome or antigen in the intestine was commonly associated with IBD.

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Section: Discussionmentioning

confidence: 99%

Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease

Dimitroulia

Spanakis

Konstantinidou

et al. 2006

Inflammatory Bowel Diseases

118

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“…[7] It has been suggested that immunosuppressives such as glucocorticoids and cyclosporine do not activate the lytic cycle of HHV-8 or modify the cell survival, thus promoting cancer progression by a direct cellular effect. [16] There are KS cases reported following treatments with corticosteroid therapy of various rheumatologic, [4] dermatologic, [17][18][19] hematologic (ITP), [20] and gastrointestinal [21,22] disorders. Nephrologists are also familiar with KS because of immunosuppressive treatment following renal transplantation, and they encounter it in HIVinfected patients as well, though less frequently.…”

Section: Discussionmentioning

confidence: 98%

A Case of Kaposi's Sarcoma Following Treatment of Membranoproliferative Glomerulonephritis and a Review of the Literature

et al. 2007

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Kaposi's sarcoma (KS) is an unusual tumor principally affecting the skin of the lower extremities. Although the association between KS and renal transplant has been well documented, there are a few KS cases in the literature associated with membranoproliferative glomerulonephritis or other glomerular diseases. This report presents a patient with membranoproliferative glomerulonephritis (MPGN) who developed KS following treatment with long-term medium dose glucocorticoid and short-term additional immunosuppressives. The KS cases associated with glomerulonephritis are also reviewed. KS is a rare complication in glomerular diseases that may (or may not) be related to immunosuppression. Hence, immunosuppression treatment should be carefully planned in glomerulonephritis treatment and avoided if they are not essentially necessary.

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“…[1][2][3][4][5]7 Although iatrogenic KS more often develops in patients undergoing solid organ transplants, there have been rare reports of iatrogenic KS in patients with inflammatory bowel disease (IBD) on immunosuppressants. [1][2][3][4][5][6][8][9][10][11][12][13] Gastrointestinal involvement is most often asymptomatic, although it may present with abdominal pain, diarrhea, and rectal bleeding, resembling an IBD flare. 4,6 Screening endoscopy is not performed in patients without risk factors such as low CD4 ,100 cells/mL, men who have intercourse with men, and presence of cutaneous KS lesions.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine-Induced Kaposi Sarcoma in a Patient With Ulcerative Colitis

et al. 2021

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Kaposi sarcoma (KS) is an angioproliferative neoplasm associated with human herpesvirus-8. Gastrointestinal KS has been well documented in immunosuppressed solid organ transplant patients, with only 26 iatrogenic cases published in patients with inflammatory bowel disease. We report a 24-year-old patient with ulcerative colitis, maintained on cyclosporine for 2 years, who presented with watery, nonbloody diarrhea and weight loss. Colonoscopy revealed human herpesvirus-8-positive hemorrhagic nodules throughout the colon and terminal ileum, with diffuse lymphadenopathy on computed tomography consistent with KS. As gastrointestinal KS may present with symptoms that mimic inflammatory bowel disease, it is critical to maintain suspicion in patients on prolonged immunosuppression to reduce complications.

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Kaposi's sarcoma and cytomegaloviral ileocolitis complicating long-standing Crohn's disease in an HIV-negative patient

Cited by 15 publications

References 22 publications

Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease

Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease

A Case of Kaposi's Sarcoma Following Treatment of Membranoproliferative Glomerulonephritis and a Review of the Literature

Cyclosporine-Induced Kaposi Sarcoma in a Patient With Ulcerative Colitis

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