Kaposi's sarcoma and other manifestations of human herpesvirus 8

Geraminejad, Pedram; Memar, Omeed; Aronson, Iris K.; Rády, Peter L.; Hengge, Ulrich R.; Tyring, Stephen K.

doi:10.1067/mjd.2002.128383

Cited by 96 publications

(75 citation statements)

References 115 publications

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“…532 Although mainly known for its association with Kaposi sarcoma (KS), HHV-8 is generally accepted to be associated with development of primary effusion lymphoma (PEL), a rare B-cell lymphoma that almost exclusively affects HIV-positive patients. 533,534 This lymphoma, however, is often associated with both HHV-8 and Epstein-Barr virus (EBV), limiting the understanding of the pathogenic role of HHV-8. 533 Judde et al 535 suggests that HHV-8 infection precedes tumor growth, which would indicate a causal role of HHV-8 in monoclonal expansions of KS and PEL.…”

Section: Interactions With Environment and Lifestyle Factorsmentioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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Section: Interactions With Environment and Lifestyle Factorsmentioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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“…Entre os tumores cutâneos, os mais intimamente relacionados à infecção viral, na literatura, são o sarcoma de Kaposi e aqueles relacionados a doenças genéticas, como xeroderma pigmentoso e EV. [20][21] Não existe confirmação experimental de oncogenia do HHV1 na pele, ainda que existam evidências de transformação viral pela radiação ultravioleta. 22,23 Paralelamente, as neoplasias cutâneas epiteliais, como o CEC, o CBC e as QA, também são mais frequentes nas áreas expostas ao sol.…”

Section: Discussionunclassified

Prevalência do herpes-vírus humano tipo 1 em neoplasias cutâneas epiteliais malignas

Ypiranga

Moraes

2009

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS -O DNA viral pode atuar como oncogene, favorecendo o desenvolvimento de neoplasias, como as linfoides e da pele. Entre esses vírus, encontram-se alguns herpes-vírus humanos. OBJETIVO -Identificar a presença de DNA do herpes-vírus humano tipo 1 em neoplasias epiteliais pré-malignas, malignas e pele normal de indivíduos controle, avaliando seu papel na carcinogênese. MÉTODOS -Identificação, por reação em cadeia da polimerase, do DNA viral do tumor e pele sã de 41 pacientes e comparação com grupo controle, sem neoplasia. Análise estatística: Testes de Fisher e de McNemar. RESULTADOS -O vírus foi identificado em 20 indivíduos sem e em 21 com neoplasia. Destes últimos, 11 o expessaram apenas nas células tumorais. A diferença, entretanto, não foi estatisticamente significante. CONCLUSÕES -Parece não haver relação direta entre o encontro do DNA viral na pele sã e na pele tumoral. Sua presença pode facilitar o desenvolvimento da neoplasia ou apenas coincidir de se localizar onde esta já ocorreu. Palavras-chave: Herpes-vírus humano 1; Neoplasias cutâneas; Reação em cadeia de polimerase; Vírus oncogênicos Abstract: Background -Viral DNA may act as an oncogene, especially in skin and lymphoid organs. This group includes some human herpes virus. Objective -To identify human herpes virus type 1 DNA in pre-malignant and malignant skin samples of epithelial tumors comparing to normal skin to determine its role in carcinogenesis. Methods -Forty-one patients with epithelial tumors were submitted to biopsies from tumor and normal skin. The control group comprised 41 biopsies from patients with other dermatoses than cancer. After DNA extraction, polymerase chain reaction was performed to identify 199-bp band. The results were statistically evaluated by Fisher and McNemar tests. Results -The virus was identified in 20 subjects without cancer and in 21 with skin cancer. From these, 11 expressed it only in tumor cells. This difference was not significant. Conclusion -There seem to be no direct relation between viral findings in normal skin and skin cancer cells. It may act as a promoter or just coexist at the same site where a neoplastic transformation has already occurred.

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“…KS is classically seen as a complication of HIV infection and in older men of Mediterranean, Central and Eastern European heritage [2]. However, iatrogenic KS can also occur in patients undergoing immunosuppressive therapies for autoimmune disorders and in patients who are transplant recipients [1].…”

Section: Letter To the Editormentioning

confidence: 99%

“…Approximately 95% of KS lesions show polymerase chain reaction (PCR) evidence of HHV8 infection [1]. KS is classically seen as a complication of HIV infection and in older men of Mediterranean, Central and Eastern European heritage [2].…”

Section: Letter To the Editormentioning

confidence: 99%