Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

Rettig, Matthew B.; Ma, H. J.; Vescio, Robert; Põld, Mehis; Schiller, Gary J.; Belson, Daniel; Savage, A.; Nishikubo, Carol Y.; Wu, Chun-Hsin; Fraser, John K.; Said, Jonathan; Berenson, James R.

doi:10.1126/science.276.5320.1851

Cited by 442 publications

(238 citation statements)

References 31 publications

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“…4 While a controversial increased incidence of multiple myeloma and other hematopoietic neoplasms in Classic Kaposi Sarcoma has been extensively reported in the literature, 14,16,18,[21][22][23][24][25][26][27][28][29] the suggested link between HHV-8 and multiple myeloma 30 supports an increase, such as noted in our study, in multiple myeloma in Kaposi Sarcoma patients. An increased incidence of other hematopoietic neoplasms was also observed in our cohort.…”

Section: Discussionsupporting

confidence: 79%

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

et al. 2008

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Section: Discussionsupporting

confidence: 79%

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

et al. 2008

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“…For example, Coussens et al (1999), using a mouse model of epithelial carcinogenesis, showed that inflammatory mast cells are involved in activating premalignant neovascularization in the skin and proposed a key functional role for these infiltrating cells during the premalignant stages of squamous carcinogenesis due to the release of specific pro-angiogenic proteases. In other studies, the production of growth factors (such as IL-6) by herpesvirusinfected dendritic cells and macrophages was shown to drive the initial proliferation of hematopoietic malignant cells and autoimmune deficiency syndromeassociated neoplasms (McGrath et al, 1995;Rettig et al, 1997). In both studies, herpesvirus sequences were detected only in the tumor-associated stromal cells (dendritic cells and macrophages) and not in the malignancies.…”

Section: Oncogenic Functions Of Stromal Cellsmentioning

confidence: 87%

New insights into the role of extracellular matrix during tumor onset and progression

Pupa

Ménard

Forti

et al. 2002

Journal Cellular Physiology

303

210

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Recently, a view of the tumor as a functional tissue interconnected with the microenvironment has recently been described. For many years, the stroma has been studied in the context of the malignant lesion, and only rarely has its role been considered before carcinogenic lesions appear. Recent studies have provided evidence that stromal cells and their products can cause the transformation of adjacent cells through transient signaling that leads to the disruption of homeostatic regulation, including control of tissue architecture, adhesion, cell death, and proliferation. It is now well established that tumor progression requires a continually evolving network of interactions between neoplastic cells and extracellular matrix. A relevant step of this process is the remodeling of microenvironment which surrounds tumors leading to the release of ECM-associated growth factors which can then stimulate tumor and/or endothelial cells. Finally, tumor cells reorganizing the extracellular matrix to facilitate communications and escape the homeostatic control exerted by the microenvironment modify response to cytotoxic treatments.

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“…The role of the EBV, HTLV, HIV, and KSHV in lymphomagenesis has been explored many times in several studies [14][15][16][17][18]. In the last years, the association between NHL and HCV has been studied extensively.…”

Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

et al. 2004

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The aim of this study is to detect the possible role of hepatitis C Virus (HCV) in lymphomagenesis. HCV‐RNA and anti‐HCV antibodies were studied in tissue and serum samples taken from patients with non‐Hodgkin's Lymphoma (NHL). The prevalence of HCV, the clinical presentation of these cases, and association with histologic subtypes were determined. RT‐PCR was used to detect the HCV‐RNA in serum and tissue samples. The anti‐HCV antibodies were tested with microparticle enzyme immunoassay. Immunohistochemistry with the ABC method was used to detect the HCV core protein in HCV‐RNA+ cases. RNA could be detected in 30 of 35 cases, and other tests were performed in these 30 samples. HCV‐RNA was detected in 11 tissue samples (11/30, 37%). HCV core protein was studied in 10 of 11 HCV‐RNA+ cases, and 1–3% nuclear staining was found in only 2 samples. Serologically, HCV‐RNA was detected in 7 of 30 samples (23.3%) and anti‐HCV antibody was detected in 3 of 30 samples (10%). Detection of HCV‐RNA in 37% of the lymphoma tissue samples suggests that HCV may have a role or is a contributing factor in the pathogenesis of lymphoma. The very low HCV core protein in lymphoma tissues may be due to the low viral load in lymphoid tissues and/or higher sensitivity of the PCR method. Detection of anti‐HCV antibody in only three cases may be associated with undetectable levels of antibodies due to the immune deficiency in cases with NHL. Am. J. Hematol. 76:252–257, 2004. © 2004 Wiley‐Liss, Inc.

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Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

Cited by 442 publications

References 31 publications

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

New insights into the role of extracellular matrix during tumor onset and progression

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

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