Kaposi's Sarcoma

Antman, Karen H.; Chang, Yuan

doi:10.1056/nejm200004063421407

Cited by 857 publications

(741 citation statements)

References 93 publications

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“…This conclusion has also been made in most of the studies conducted around the world on the main risk factors for women to acquire HHV-8 [1,2,7,8,10]. On the other hand, if we consider the antibodies detected in children to be maternal antibodies, we can identify the intravenous (blood) route as another route of virus transmission and/or acquisition.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma

Caterino–de–Araujo¹,

Santos-Fortuna²,

Carbone³

et al. 2003

Braz J Infect Dis

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Section: Discussionmentioning

confidence: 80%

“…Female hormones, such as human chorionic gonadotropin and luteinizing hormone, may play a role in KS avoidance [6]. Other factors have been pointed out as regulators of KS outcome, such as the interruption of posttransplant immunosuppressive therapy in KS, and the use of highly active antiretroviral therapy (HAART) by HIV-infected individuals [7][8].…”

mentioning

confidence: 99%

Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma

Caterino–de–Araujo¹,

Santos-Fortuna²,

Carbone³

et al. 2003

Braz J Infect Dis

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“…HHV-8 infects CD 19 -positive B cells as well as endothelial-derived spindle cells of Kaposi's sarcoma. 2 Coincidental immunosuppression resulting from either HIV infection, advancing age or post-organ transplantation is required before Kaposi's sarcoma becomes manifest. KSHV is found in 95% of all forms of Kaposi's sarcoma but rarely in control patients without AIDS or Kaposi's sarcoma.…”

mentioning

confidence: 99%

Treatment of AIDS-associated Kaposi's sarcoma in Zimbabwe: Results of a randomized quality of life focused clinical trial

Olweny¹,

Borok

Gudza

et al. 2004

Int. J. Cancer

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Kaposi's sarcoma is currently the most common tumor in Zimbabwe. The purpose of our study is to compare the effectiveness of supportive care vs. 3 intervention approaches, namely oral Etoposide, a 3-drug combination, and radiotherapy using quality of life (QOL) as the primary measure of success. In addition, our study was to determine whether a disease-specific module has greater sensitivity to group differences than a generic QOL questionnaire and to determine the most pragmatic approach to treating epidemic Kaposi's sarcoma (EKS) in Zimbabwe. In addition, on the physical and psychological subscales, the Etoposide group had a significantly better QOL than the other 3 treatment groups (p < 0.04). The 3-drug combination, supportive care and radiotherapy groups did not differ significantly from each other with respect to the total FLI-C score or its subscales. There were no group differences with respect to survival. Oral Etoposide therapy resulted in better total FLI-C QOL score than radiotherapy. As well, Etoposide resulted in better physical and psychological subscale scores than radiotherapy, 3-drugs and supportive care. Thus, funds permitting, oral Etoposide is a pragmatic approach to treating EKS in an environment where antiretroviral drugs are not universally available. The study underscores the value of undertaking studies in areas of disease prevalence and the necessity of selecting appropriate outcome measures.

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“…The annual incidence is between 0.02 and 0.06% of all malignant tumors. 7 KS rarely affects American or European heterosexuals, but it often occurs in African or Caribbean heterosexuals. 8 Most patients with pulmonary KS already present with cutaneous lesions at the time of diagnosis; however, visceral disease may occasionally precede the skin.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Kaposi’s sarcoma in a female patient: Case report

Petribu¹,

Cisneiros²,

Carvalho³

et al. 2016

Rev. Assoc. Med. Bras.

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SUMMARY Kaposi’s sarcoma (KS) is a multicentric lymphoproliferative malignancy. Most of the time this tumor is confined to the skin and subcutaneous tissue, but it can present with widespread visceral involvement, such as in the lung. Pulmonary KS is the most frequent form in young adult males, in a ratio of 15:1. The disease usually affects individuals with low CD4 lymphocyte counts (<150-200 cells/mm3). We report a case of a female patient aged 35 years, with the presence of skin lesions, self-limiting episodes of diarrhea and weight loss of 15 kg for nearly 9 months, progressing to persistent fever. AIDS was diagnosed and biopsy of the lesions revealed Kaposi’s sarcoma. Computed tomography of the chest showed peribronchovascular thickening, areas of ground glass opacity, condensations with air bronchograms surrounded by ground glass opacity (halo sign) and bilateral pleural effusion. The diagnosis of pulmonary KS is still a challenge, especially due to the occurrence of other opportunistic diseases that may also occur concurrently. Therefore, suspecting this diagnosis based on clinical and laboratory manifestations, and even more with CT findings, is fundamental, especially in patients who already have the cutaneous form of the disease.

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Kaposi's Sarcoma

Cited by 857 publications

References 93 publications

Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma

Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma

Treatment of AIDS-associated Kaposi's sarcoma in Zimbabwe: Results of a randomized quality of life focused clinical trial

Pulmonary Kaposi’s sarcoma in a female patient: Case report

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