It is well known that herpesviruses are pantropic, hence herpetic infections are characterized by a diverse clinical pattern. Often one of the syndromes of various «herpetic nosologic forms» is the exanthema syndrome. Traditionally, this is a vesicular rash accompanying the infection caused by herpes simplex virus, which occupies a fairly limited area, but the rashes can be completely different in nature, quantity, and localization. The article discusses a relatively rare variant of herpetic infection, called: Kaposi’s varicelliform eruption (eczema herpeticum), or Kaposi–Juliusberg varioliform pustulosis, characterized by the severity of clinical manifestations, often an unfavorable outcome, diagnostic and therapeutic difficulties. Photo documents of the dynamics of the skin process and laboratory parameters against the background of antiviral therapy are presented.