Kaposi's Varicelliform Eruption in a Patient with Healing Peribucal Dermabrasion

Bestue, Mercedes; Cordero, Alejandro

doi:10.1046/j.1524-4725.2000.026010939.x

Cited by 18 publications

(11 citation statements)

References 6 publications

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“…It has also been reported in association with psoriasis, pityriasis rubra pilaris, Darier’s, Grover’s, and Hailey–Hailey diseases,[ 1 5 ] and contact dermatitis (both irritant and allergic),[ 6 ] among others. [ 1 4 7 8 9 10 ] Of note, one of our patients developed KVE while being treated with prednisone 60 mg per day and cyclophosphamide 150 mg per day for pemphigus foliaceus [ Figure 4 ]. Another developed it while on extracorporeal photopheresis for Sezary syndrome.…”

Section: Discussionmentioning

confidence: 99%

Kaposi′s varicelliform eruption: A case series

Ferrari

Taliercio

Luna

et al. 2015

Indian Dermatol Online J

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Kaposi's varicelliform eruption is a rare and potentially fatal viral infection caused mainly by reactivation of herpes simplex virus. It concomitantly occurs with pre-existing skin conditions, mostly atopic dermatitis, so it is predominately found in children. We present a case series that includes four adults, familial cases, and previously healthy patients. We also highlight clinical features, associations and therapeutic options.

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Section: Discussionmentioning

confidence: 99%

Kaposi′s varicelliform eruption: A case series

Ferrari

Taliercio

Luna

et al. 2015

Indian Dermatol Online J

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“…This widespread herpes infection, termed 'eczema herpeticum' (or Kaposi's varicelliform eruption), cannot be explained by a potential immunological defect in atopic dermatitis alone, since the clinical phenotype of eczema herpeticum can also be observed to occur in patients who have other heritable skin diseases due to epidermal defect, termed Darier's disease and Hailey-Hailey disease (familial benign pemphigus), which are not known to have immunological defect [104][105][106][107]. Furthermore, eczema herpeticum has been reported to occur after dermabrasion, a surgical procedure that physically causes skin barrier defect, or in healing burned skin where skin barrier is compromised [108,109]. Similarly, when atopic dermatitis patients were immunized with smallpox vaccine, the vaccinia virus induced a potentially fatal widespread punched-out lesion termed 'eczema vaccinatum' like that of eczema herpeticum, in these patients [110].…”

Section: Data From Human Patient Studiesmentioning

confidence: 99%

Atopic Dermatitis in 2008

Chan¹

2008

Current Directions in Autoimmunity

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Atopic dermatitis (also termed atopic eczema and infantile eczema), a chronic, itchy, inflammatory skin disease that sets on at infancy or early childhood, is observed with increasing prevalence around the world, particularly in developed nations. Although sufficient evidences are not yet available to define it as a classical autoimmune disease, autoantigens have been identified. Investigations of atopic dermatitis in human patients and animal models suggest that this disease is initiated, maintained and perpetuated by the actions of cytokines, chemokines, T cells, antigen-presenting cells and other inflammatory cells; there is also evidence of skin barrier defect and angiogenesis. Recent identification of mutations of the epidermal barrier protein filaggrin (encoded by FLG), present in about 9% of people of European origin, with 70% of individuals homozygous or compound heterozygous for FLG null alleles developing atopic dermatitis, provides a strong link between a defect of the epidermal barrier that allows easy penetration of pathogen/allergen through the skin and a systemic hyperactive immune response to the penetrated pathogen/allergen. The newly introduced concept of 'intrinsic' and 'extrinsic' atopic dermatitis has fueled the debate among academic dermatologists as to how 'atopic' atopic dermatitis should be defined. Some recent advancements on the management options for atopic dermatitis are also discussed.

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“…Children are most commonly affected, but the disease can occur in individuals of all ages [3]. Eczema is the main predisposing factor, but KVE may appear with many other inflammatory skin disorders that disrupt skin integrity, such as second degree burns, dermabrasion, rosacea, pemphigus, and keratosis follicularis [1,2,4]. KVE has also been associated with mycosis fungoides, Sezary syndrome, pregnancy, autografted skin, and use of cellmediated immunosuppressive agents, such as topical tacrolimus for the treatment of eczema [2,[5][6][7].…”

mentioning

confidence: 99%