Kaposi Sarcoma in an Immunosuppressed Patient With Presumed Crohn’s Disease: Iatrogenic or Epidemic?

Claytor, Jennifer; Viramontes, Omar; Conner, Stephanie; Wen, Kwun Wah; Beck, Kendall

doi:10.1053/j.gastro.2021.01.034

Cited by 3 publications

(2 citation statements)

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“…The KS in patients with HIV and IBD is extremely rare with few cases ever reported [6][7][8]. Similarly, visceral KS is rarely present at the initial diagnosis of HIV, with an incidence of about 15% [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Though, our patient required an endoscopy and colonoscopy given new dysphagia and weight loss, as well as an unclear prior diagnosis of IBD. While it may be reasonable to start corticosteroids, or anti-tumor necrosis factor-alpha for IBD flares in patients receiving HAART or with CD4+ >500, the safety of starting such treatments have not been studied in those with uncontrolled HIV as in our case [6,[14][15][16].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identifying Visceral Kaposi Sarcoma (KS): A Responsibility to Avoid Anchoring on the Diagnosis of a Crohn’s Flare

Seltzer¹,

Shenoy²,

Yoon³

et al. 2023

Cureus

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The initial evaluation of reported inflammatory bowel disease (IBD) should include an assessment for immunosuppression which can broaden the differential diagnosis to include opportunistic infection as well as other processes. Here we present an exceedingly rare case of a patient with a self-reported history of Crohn's disease presenting with frequent diarrhea presumed to be a Crohn's flare, however, after further workup was found to have extensive visceral Kaposi sarcoma (KS).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identifying Visceral Kaposi Sarcoma (KS): A Responsibility to Avoid Anchoring on the Diagnosis of a Crohn’s Flare

Seltzer¹,

Shenoy²,

Yoon³

et al. 2023

Cureus

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Mimics of Crohn's Disease

Gupta

Allegretti

2022

Gastroenterology Clinics of North America

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Cutaneous Kaposi’s Sarcoma Following Long-Term Infliximab Treatment in a Patient with HIV-Negative Antibiotic-Dependent Chronic Pouchitis: Considerations on an Exceptional Finding

Pellegrino,

Palladino,

Pagliuca

et al. 2024

Gastrointestinal Disorders

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In managing ulcerative colitis (UC), anti-tumour necrosis factor (TNF) agents are among the primary choices. Evidence suggests anti-TNF does not significantly increase malignancy risk (apart from lymphoma and melanoma), though uncertainties persist due to inconsistent long-term data. Kaposi’s sarcoma (KS), induced by human herpesvirus type-8 (HHV-8), is a multifocal neoplasm linked to immunosuppressive therapies, primarily affecting the skin and gastrointestinal tract. KS cases during anti-TNF therapy for UC are anecdotal. We report a rare occurrence of KS in the setting of the long-term use of the standard maintenance dose of infliximab (initiated in 2010) in a 56-year-old male patient with UC diagnosed in 2001. The patient underwent restorative proctocolectomy with ileal J-pouch-anal anastomosis in 2002 and subsequently developed chronic antibiotic-dependent pouchitis. Given the secondary loss of response to infliximab, a switch to vedolizumab was performed. In April 2024, the patient reported the presence of a skin lesion on the right leg. Following surgery, a rhomboid-shaped skin area was removed, encompassing the irregular, greyish KS lesion. The histopathological analysis confirmed the diagnosis of patch-like KS. We continued vedolizumab due to its gut-selective profile. The patient is in clinical remission and under dermatological follow-up with no lesion recurrence.

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Kaposi Sarcoma in an Immunosuppressed Patient With Presumed Crohn’s Disease: Iatrogenic or Epidemic?

Cited by 3 publications

References 0 publications

Identifying Visceral Kaposi Sarcoma (KS): A Responsibility to Avoid Anchoring on the Diagnosis of a Crohn’s Flare

Identifying Visceral Kaposi Sarcoma (KS): A Responsibility to Avoid Anchoring on the Diagnosis of a Crohn’s Flare

Mimics of Crohn's Disease

Cutaneous Kaposi’s Sarcoma Following Long-Term Infliximab Treatment in a Patient with HIV-Negative Antibiotic-Dependent Chronic Pouchitis: Considerations on an Exceptional Finding

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