Kaposiform Hemangioendothelioma in Adults:<i>Clinicopathologic and Immunohistochemical Analysis of Three Cases</i>

Mentzel, Thomas; Mazzoleni, Guido; Tos, Angelo Paolo Dei; Fletcher, Christopher D.�M.

doi:10.1093/ajcp/108.4.450

Cited by 113 publications

(64 citation statements)

References 5 publications

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“…This finding is notable because both of these tumors have been postulated to show lymphatic endothelial differentiation, on the basis of their characteristic infiltration by lymphocytes (29,30), the association of the former with lymphangiomatosis (29,31), and their reported usual absence of vWF expression (29,31). We observed vWF expression in 80% of kaposiform hemangioendothelioma and all Dabska tumors; again, this difference may be the result of our use of heat-induced epitope retrieval.…”

Section: Discussionmentioning

confidence: 59%

Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3): A Marker of Vascular Tumors with Presumed Lymphatic Differentiation, Including Kaposi's Sarcoma, Kaposiform and Dabska-Type Hemangioendotheliomas, and a Subset of Angiosarcomas

et al. 2000

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Recently, a novel monoclonal antibody to vascular endothelial growth factor receptor 3 (VEGFR-3), a tyrosine kinase receptor expressed almost exclusively by lymphatic endothelium in the adult, has been shown to react with a small number of cases of Kaposi's sarcoma (KS) and cutaneous lymphangiomas. We sought to extend these studies to a large number of well-characterized vascular neoplasms to evaluate diagnostic uses of this antibody and to determine whether it defines them in a thematic fashion.

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Section: Discussionmentioning

confidence: 59%

Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3): A Marker of Vascular Tumors with Presumed Lymphatic Differentiation, Including Kaposi's Sarcoma, Kaposiform and Dabska-Type Hemangioendotheliomas, and a Subset of Angiosarcomas

et al. 2000

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“…In our case, the histological appearance of the tumor had remarkable resemblance of the spindle cell proliferation of dog and human KHE [5,6]. The vascular origin was confirmed by its histological appearance with evident blood vessels (which contain numerous erythrocytes) and by its positivity to factor VIII-related antigen, a universally accepted marker for endothelial cells, also expressed in bovine endothelial cells [4].…”

mentioning

confidence: 51%

“…In humans, hemangioendotheliomas are classically tumors of "intermediate" or "borderline" malignancy and are classified into spindle cell, retiform, polymorphous and kaposiform hemangioendotheliomas [2,6]. The Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor found almost exclusively in early childhood with a wide anatomical distribution.…”

mentioning

confidence: 99%

Kaposi-Like Vascular Tumor of the Urinary Bladder in a Cow

Pires

Queiroga

Silva

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Kaposiform hemangioendothelioma is a rare human vascular neoplasm. In veterinary medicine this tumor type was only recognized in the dog. Here we describe an unusual case arising in the urinary bladder of a Holstein-Friesian adult cow. Histologically the tumor presented a nodular proliferation of spindle cells, forming angular slits, often containing extravasated erythrocytes. Peripherically, well-formed vascular channels were seen. These cells were positive to vimentin and to factor VIII-related antigen by immunohistochemical stain. Based on its characteristics, it was classified as kaposiform hemangioendothelioma and as far as we know, it is the first case described in cattle.KEY WORDS: cattle, Kaposiform hemangioendothelioma, urinary bladder, vascular tumor.

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“…KHE typically occurs during infancy and in the first decade of life. Although KHE may also develop in adults, only approximately 20 adult KHE patients have been reported (table 1) [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]; most of them were not associated with KMS [6]. KHE rarely originates from bone without accompanying cutaneous changes.…”

Section: Introductionmentioning

confidence: 99%

CyberKnife Treatment for Kaposiform Hemangioendothelioma of the Ilium in an Adult: Case Report and Review of the Literature

Wang¹,

Kong

Wu³

et al. 2014

Oncol Res Treat

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Background: Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that mainly affects infants. KHE rarely develops in adolescents and adults. These tumors tend to be locally invasive, but are not known to produce distant metastases. Numerous treatment modalities are available for KHE, but the optimal therapy is unknown. Case Report: A 51-year-old woman was diagnosed with KHE of the ilium in September 2005. The lesion recurred within 5 years of local excision, and was subsequently treated with CyberKnife. Within 1 month of CyberKnife therapy, pain intensity was significantly reduced and the patient's quality of life was significantly improved. Since January 2011, she has remained pain-free and has had no signs of recurrence or metastasis for more than 2 years following CyberKnife therapy. Conclusion: We report the first CyberKnife treatment of an adult with KHE of the bone without accompanying cutaneous changes and Kasabach-Merritt syndrome. CyberKnife treatment could be a useful temporizing measure for bone KHE.

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Kaposiform Hemangioendothelioma in Adults:Clinicopathologic and Immunohistochemical Analysis of Three Cases

Cited by 113 publications

References 5 publications

Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3): A Marker of Vascular Tumors with Presumed Lymphatic Differentiation, Including Kaposi's Sarcoma, Kaposiform and Dabska-Type Hemangioendotheliomas, and a Subset of Angiosarcomas

Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3): A Marker of Vascular Tumors with Presumed Lymphatic Differentiation, Including Kaposi's Sarcoma, Kaposiform and Dabska-Type Hemangioendotheliomas, and a Subset of Angiosarcomas

Kaposi-Like Vascular Tumor of the Urinary Bladder in a Cow

CyberKnife Treatment for Kaposiform Hemangioendothelioma of the Ilium in an Adult: Case Report and Review of the Literature

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