Kaposiform hemangioendothelioma with fatal income: Kasabach–Merritt phenomenon and hypercalcemia

Baklouti, Massara; Rekik, Mariem; Bahloul, E.; Triki, Mouna; Safi, Faiza; Boudaya, S.; Amouri, M.; Gargouri, L.; Sellami, Tahya; Turki, H.

doi:10.1002/ccr3.5458

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Presentation of these symptoms worsens the prognosis of the patient because it supports tumor growth and infiltration, hemodynamic instability, and compression of vital structures in the body. As the laboratory examination did not show any signs of coagulation disorder the anemia was most likely caused by the location and rapid growth of the tumor [5 , 6] .…”

Section: Discussionmentioning

confidence: 89%

Digital subtraction angiography and trans arterial embolization in preventing massive hemorrhage of Kaposiform hemangioendothelioma: A case report

Sidipratomo

Pandelaki

Ramandika

et al. 2022

Radiology Case Reports

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Section: Discussionmentioning

confidence: 89%

Digital subtraction angiography and trans arterial embolization in preventing massive hemorrhage of Kaposiform hemangioendothelioma: A case report

Sidipratomo

Pandelaki

Ramandika

et al. 2022

Radiology Case Reports

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“…Children diagnosed with KMP are often susceptible to morbidity and mortality due to congenital vascular anomalies that result in haemorrhaging, invasion, or compression of critical structures by vascular tumours. Such occurrences are commonly observed in conjunction with children affected by KMP 4 …”

Section: Introductionmentioning

confidence: 97%

Spontaneous haemothorax as a complication of Kassabach‐Merritt phenomenon (KMP) in a‐2‐years old female child: A case report

Cesilia,

Ridar,

Hatta

et al. 2023

Respirology Case Reports

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Kasabach‐Merritt phenomenon (KMP) is a rare condition that is associated with two rare vascular tumours: Kapossiform haemangioendothelioma (KHE) and tufted angioma (TA). A 2‐year‐old girl presented to our emergency room with a haemangioma and respiratory distress. The patient had a violaceous, palpable mass in the right upper chest since she was 5 months old. Severe anaemia, thrombocytopenia, coagulopathy, and hypofibrinogenemia were found. Chest x‐ray revealed massive pleural effusion in the right hemithorax. Chest computed tomography (CT) scanning revealed right pleural effusion, multiple destructions of bilateral ribs and multiple osteopenia of thoracic vertebrae. Chest CT angiography revealed a vascular mass in the sternum region. Based on clinical, laboratory and imaging findings, the diagnosis of KMP was established. Clinical, consumptive coagulopathy and thrombocytopenia were resolved by prednisone (3 mg/kg/day) and vincristine (1 mg/body surface area in m2/week) as an adjunct. Unfortunately, she had spontaneous rebleeding and died before the biopsy was done.

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A case report of primary Kaposiform hemangioendothelioma of the humerus

Wang,

He,

Hao

2024

Int J Immunopathol Pharmacol

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To examine the clinicopathological and immunohistochemical features of Kaposiform hemangioendothelioma (KHE) and discuss its differential diagnosis and prognosis. A patient with KHE was examined; the patient’s clinical and histopathological features were observed, and the expression levels of CD31, CD34, ERG, D2-40, SMA, GLUT-1, and LANA-1 were assessed. The patient was a four-year-old child with primary KHE of the humerus. She was admitted to the hospital because of pain in the right elbow joint and limited movement for more than 2 years. Imaging revealed Langerhans cell histiocytosis. The child was not diagnosed with Kasabach-Merritt phenomenon (KMP). The tumor consists of multiple hemangiomatous nodules with infiltrative growth separated by fibrous connective tissue. The proliferating hemangiomatoid nodules consisted of crisscrossing short spindle-shaped cell bundles and erythrocyte-containing lacunar or crescentic vessels. Immunohistochemical staining showed that the tumor cells diffusely expressed CD31, CD34, ERG, and other vascular endothelium-derived markers; further, the tumor cells expressed neither GLUT-1 nor LANA-1. The patient’s general condition improved after surgical resection. There was no tumor recurrence after more than 8 months of follow-up. Primary KHE of the humerus is a rare vasculogenic tumor. It presents with morphological features that require an accurate differential diagnosis.

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Kaposiform hemangioendothelioma with fatal income: Kasabach–Merritt phenomenon and hypercalcemia

Cited by 4 publications

References 6 publications

Digital subtraction angiography and trans arterial embolization in preventing massive hemorrhage of Kaposiform hemangioendothelioma: A case report

Digital subtraction angiography and trans arterial embolization in preventing massive hemorrhage of Kaposiform hemangioendothelioma: A case report

Spontaneous haemothorax as a complication of Kassabach‐Merritt phenomenon (KMP) in a‐2‐years old female child: A case report

A case report of primary Kaposiform hemangioendothelioma of the humerus

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