Karanjin

Singh, Anuma; Bhatt, Gaurav; Gujre, Nihal; Mitra, Sudip; Swaminathan, Rajaram; Limaye, Anil Mukund; Rangan, Latha

doi:10.1016/j.phytochem.2020.112641

Cited by 30 publications

(24 citation statements)

References 60 publications

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“…(Zingiberaceae) (Roots), Elettaria cardamomum Maton (Zingiberaceae) (Seed pods), Syzygium aromaticum (L.) Merr. & Perry (Myrtaceae) (Buds) 1 , Mentha longifolia, Mentha piperita, Mentha spicata, and Nepeta cataria 10 , A. indica, Eucalyptus globules, Ocimum basilicum L. 11 were used for the management of P. solenopsis. Further, neem oil and NSKE 12 , biopesticides and biorationals insecticides 13 or commercial need product (Neemosal) 14 were also tested against P. solenopsis.…”

Section: Introductionmentioning

confidence: 99%

“…Proposed plants like Annona squamosa 15 , Justicia adatoda 16 , Ipomea carnea 17,18 and Pongamia glabra (= Pongamia pinnata) 11,19 showed insecticidal, repellent and antifeedant properties against various insect pests have been known for three decades. However, crude extracts of these plants have not tested against various life stages of P. solenopsis.…”

Section: Introductionmentioning

confidence: 99%

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Insecticidal activity of crude extracts of four plants and their Ag Nano liquids against Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae)

Madasamy

Sahayaraj

Sayed

et al. 2022

Preprint

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A good quantity of global agricultural production is being devastated due to insect pests which need serious attention by the agricultural scientists and policy makers. The sole dependence on agrochemicals has increased over the past decades. However, adoption of botanical insecticides is gaining momentum as an ecofriendly alternative to the hazardous chemical pesticides. Applications of bionanoparticles are highly effective and may limit the risk of synthetic pesticide usage. Leaf dip and topical application toxicity bioassay were carried out to investigate the biological effects of aqueous leave extracts of Annona squamosa, Justicia adathoda, Ipomea carnea and Pongamia glabura at different concentrations (1.25, 2.5, 5 and 10%) against first, second, third nymphal instars and adult of Phenacoccus solenopsis (Hemiptera: Pseudococcidae). The result suggest that the aqueous leaf extract of P. glabura (LC50 = 9.673%) showed more impact after 144 hrs of exposure followed by J. adathoda, I.carnea and A. squamosa in leaf dip toxicity bioassay. In the topical application, P. glabura (LC50 = 1.042%) recorded the highest insecticidal activity followed by other three tested plants. The AgNP’s of P. glabura-AgNP’s showed highest impacts (LC50 = 4.750%) than other three tested nanoparticles i.e., I.carnea-AgNP’s, J. adathoda-AgNP’s, A. squamosa-AgNP’s in addition to Vijay neem, respectively. From these experiments, it is evident that the P. glabura-AgNP’s and J.adathoda-AgNP’s possess more insecticidal activity and hence these products could be used for P. solenopsis management.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insecticidal activity of crude extracts of four plants and their Ag Nano liquids against Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae)

Madasamy

Sahayaraj

Sayed

et al. 2022

Preprint

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“…Recent reports have revealed that its radix also has the pharmacological effects such as cardiovascular protection, hepatoprotection and anti-tumor properties [1,2]. These bio-activities have been associated with a number of isolated flavonoids, such as karanjin, lanceolatin B and pongamol [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The unique furanoflavonoid karanjin was first isolated from Pongamia pinnata (L.) Pierre [6]. The reports on in vitro and in vivo studies of karanjin suggests that it exhibits significant biological effects, including anti-tumor, anti-inflammatory, anti-diabetic, antioxidant, and anti-colitis activities [1,2,6,7]. These medicinal properties are mainly attributed to its anti-oxidant effect via the TNF-α signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

“…These medicinal properties are mainly attributed to its anti-oxidant effect via the TNF-α signaling pathway. Karanjin has been also demonstrated to stimulate GLUT4 translocation to plasma via triggering AMP-activated protein kinase (AMPK), without including PI 3-kinase and protein kinase B (AKT), which modulates TNF and insulin signaling, plays a vital role in cell cycle arrest, metabolism, and drug efflux, and inhibits ROS [4,6].…”

Section: Introductionmentioning

confidence: 99%

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Quantification and Optimization of Ethanolic Extract Containing the Bioactive Flavonoids from Millettia pulchra Radix

Liaw

Lin

et al. 2021

Molecules

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Millettia pulchra is traditionally used for treating diseases, including joint pain, fever, anemia, and allergies. It is also a potential resource of natural flavonoid derivatives, which represents major constituents of this plant. This study aimed to isolate the major compounds from M. pulchra radix, develop and validate the HPLC-PDA method to determine their contents, and optimize its extraction. Four major flavonoid derivatives (karanjin, lanceolatin B, 2”,2”-dimethylpyrano-[5″,6″:7,8]-flavone, and pongamol) were isolated using silica gel column chromatography, crystallization techniques in large amounts with high purities (>95%). A simple, accurate high-performance liquid chromatography–photodiode array (HPLC–PDA) detection method has been developed and validated with significantly statistical impacts according to International Conference on Harmonization (ICH) guidelines. The Response Surface Methodology (RSM), Artificial Neural Network (ANN) models were employed to predictive performance and optimization of the extraction process. The optimized conditions for the extraction of major flavonoids were: extraction time (twice), solvent/material ratio (9.5), and ethanol concentration (72.5%). Our research suggests an effective method, which will be helpful for quality control in the pharmaceutical development of this species.

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The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway

Han

et al. 2022

Drug Development Research

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Karanjin is a bioactive furanoflavonoid with various pharmacological activities including anticancer activities. However, the effect and the related mechanism of karanjin in breast cancer (BC) have not been revealed. The potential targets of karanjin and BC were predicted using SwissTargetPrediction and GeneCards databases, respectively. The overlapping targets between karanjin and BC were identified using the Venn diagram. DAVID database was used for the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway analysis. Cell viability, proliferation, and apoptosis were examined by MTT (3-(4, 5-dimethyl-2thiazolyl)-2, 5-diphenyl-tetrazolium bromide), EdU (5-ethynyl-2′-deoxyuridine) incorporation, and TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP digoxigenin nick-end labeling) assays, respectively. The protein levels were measured by western blot analysis. We screened out 28 overlapping targets between karanjin and BC. KEGG analysis showed that the targets of karanjin in BC were associated with the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway.Karanjin inhibited cell viability and impeded the proliferative ability of BC cells.Moreover, karanjin treatment induced apoptosis in BC cells. Additionally, karanjin treatment blocked the PI3K/Akt signaling pathway and activation of the PI3K/Akt pathway reversed the antitumor effect of karanjin on BC cells. In conclusion, karanjin exerted antitumor activity in BC cells by regulating the PI3K/Akt signaling pathway.

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Karanjin

Cited by 30 publications

References 60 publications

Insecticidal activity of crude extracts of four plants and their Ag Nano liquids against Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae)

Insecticidal activity of crude extracts of four plants and their Ag Nano liquids against Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae)

Quantification and Optimization of Ethanolic Extract Containing the Bioactive Flavonoids from Millettia pulchra Radix

The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway

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