The development and utilization of land in the main urban area have significantly impacted the stability of the regional geological environment through various means, such as increased load and subway construction, primarily manifested as rock and soil mass deformation leading to geological hazards. Therefore, it is worth exploring how to reduce the occurrence of karst ground subsidence (KGS) through reasonable land development and control measures in the main urban areas with large-scale developments of buried karst formations. This study focuses on the main urban area of Wuhan City. An evaluation model for KGS was constructed using the analytic hierarchy process (AHP) and comprehensive index evaluation method by analyzing the geological conditions that affect KGS. The susceptibility zoning of KGS was obtained with GIS spatial analysis technology. The results show that the susceptible areas can be divided into extreme, high, medium, and weak susceptibility, accounting for 4.93%, 15.30%, 33.21%, and 46.56%, respectively, which are consistent with the distribution density of past KSGs. Furthermore, by selecting the subway construction as a human activity type, it indirectly discusses the influence of land development intensity on KGS. The results show that past KSGs are mainly concentrated in areas with high engineering construction density and significant land development intensity. Based on the above, strategies for regional land development and prevention and control of KGSs are proposed.