Karwinskia Species (Buckthorn): In Vitro Culture, Micropropagation, and the Production of Toxin Anthracenone

Lišková, Desana; Lee, Alexander; Piñeyro-López, Alfredo; Luján-Rangel, R.

doi:10.1007/978-3-662-08614-8_13

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The genus Karwinskia (Rhamnaceae family) consists of small trees and shrubs native to southern United States and Mexico in North America; Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica, and Panama in Central America; Colombia and Venezuela in South America; and Cuba, Haiti, and the Dominican Republic in the Caribbean [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…There are 22 accepted species of Karwinskia (Table 1, [2,3]). Species are often spined; leaves are simple, opposite or nearly so, usually stipulate, entire or toothed; flowers are greenish or yellowish grouped in short-stemmed clusters in the axils of the leaves; the fruit is capsular or drupaceous, green when immature turns dark purple on ripening; the wood is hard and strong [1,2,4]. K. humboldtiana is the most widespread and studied of the species, and is also known as tullidora, cacachila, coyotillo, tuvii, capulin, wild cherry, and pimientillo, among other names [5].…”

Section: Introductionmentioning

confidence: 99%

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Toxicity and Anticancer Potential of Karwinskia: A Review

et al. 2020

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Karwinskia genus consists of shrubs and small trees. Four toxic compounds have been isolated from Karwinskia plants, which were typified as dimeric anthracenones and named T496, T514, T516, and T544. Moreover, several related compounds have been isolated and characterized. Here we review the toxicity of the fruit of Karwinskia plants when ingested (accidentally or experimentally), as well as the toxicity of its isolated compounds. Additionally, we analyze the probable antineoplastic effect of T514. Toxins cause damage mainly to nervous system, liver, lung, and kidney. The pathophysiological mechanism has not been fully understood but includes metabolic and structural alterations that can lead cells to apoptosis or necrosis. T514 has shown selective toxicity in vitro against human cancer cells. T514 causes selective and irreversible damage to peroxisomes; for this reason, it was renamed peroxisomicine A1 (PA1). Since a significant number of malignant cell types contain fewer peroxisomes than normal cells, tumor cells would be more easily destroyed by PA1 than healthy cells. Inhibition of topoisomerase II has also been suggested to play a role in the effect of PA1 on malignant cells. More research is needed, but the evidence obtained so far indicates that PA1 could be an effective anticancer agent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicity and Anticancer Potential of Karwinskia: A Review

et al. 2020

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“…Therefore our attention was focused to these effects of GGMOs in K. humboldtiana root culture. Genus Karwinskia is interesting for the production of cancerostatic and antibacterial substances, for that reason vegetative propagation and the rooting ability of the two most important species of this genus, K. humboldtiana and K. parvifolia, in vivo as in vitro was examined formerly by Luján-Rangel (Lišková et al 1999), Henselová et al (2002), Kollárová-Sadloňová et al (2003).…”

Section: Introductionmentioning

confidence: 99%

Influence of galactoglucomannan oligosaccharides on root culture of Karwinskia humboldtiana

Kollárová

Lišková

Lee

2007

Plant Cell Tiss Organ Cult

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Galactoglucomannan oligosaccharides (GGMOs) activity in K. humboldtiana root culture has been determined. GGMOs inhibited adventitious root growth and lateral root induction in contrast to IAA, IBA, and NAA stimulating effect in these processes. Similarly, the combination of GGMOs with natural auxins (IAA, IBA) evoked an inhibition of adventitious root growth and lateral root induction that depended on the oligosaccharides concentration and the type of auxin. The growth stimulating effect of the synthetic auxin, NAA, in adventitious roots was negatively affected by GGMOs, but they were without influence on lateral root induction. The presence of oligosaccharides triggered lateral root position on adventitious roots and the anatomy of adventitious roots (diameter, proportion of primary cortex to the central cylinder, number and size of primary cortical cells, intercellular spaces, and the number of starch grains in cells of primary cortex) in dependence on their coactions with auxin.

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Effect of growth regulators on rooting cuttings of Karwinskia species under in vivo conditions

Henselová¹,

Lee²,

Masarovičová³

2002

PLANT SOIL ENVIRON

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Effect of the growth regulators Atonik, Rastim 30 DKV, Stimulator AS 1, and Stimulax III on rooting of half-woody shoots of the species Karwinskia humboldtiana (Roem et Schut) Zucc. and Karwinskia parvifolia Rose was studied. Rooting does not occur without stimulation in these species, after stimulation rhizogenesis takes 14 to 16 weeks. Growth regulators, with the exception of the preparation Atonik, showed a significantly stimulating effect on rhizogenesis, and effect of them declined in the order Stimulax III, Stimulator AS, and Rastim 30 DKV. The percentage of rooting in the species Karwinskia humboldtiana was higher than that in Karwinskia parvifolia and this was dependent on the age of the plants, the type of stimulator, cutting, substrate, and conditions of cultivation.

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Karwinskia Species (Buckthorn): In Vitro Culture, Micropropagation, and the Production of Toxin Anthracenone

Cited by 3 publications

References 18 publications

Toxicity and Anticancer Potential of Karwinskia: A Review

Toxicity and Anticancer Potential of Karwinskia: A Review

Influence of galactoglucomannan oligosaccharides on root culture of Karwinskia humboldtiana

Effect of growth regulators on rooting cuttings of Karwinskia species under in vivo conditions

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