Karyotype analysis in acute nonlymphocytic leukemia (ANLL): Comparison with ethnic group, age, morphology, and survival

Bernstein, R; Pinto, M. R.; Morcom, G.; Macdougall, Lorna G.; Bezwoda, W. R.; Dukes, I. A. F.; Penfold, G.; Mendelow, B.

doi:10.1016/0165-4608(82)90056-5

Cited by 44 publications

(6 citation statements)

References 21 publications

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“…Our results show that there were no statistically significant differences in the frequencies of FAB subtypes among the patient age groups, though the most frequent FAB subtype was different in each age group. However, in consistent with previous reports [8,6,17] , the distribution of karyotypes in AML obviously showed age differences. The frequencies of t(8;21) and 11q23 descended and that of 5/7/8 ascended with an increase of patient age, respectively.…”

Section: Resultssupporting

confidence: 81%

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Age Difference in Immunophenotype of Acute Leukemia

Nakase¹,

Sartor²,

Bradstock³

2006

American J. of Immunology

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Abstract:We examined the immunophenotype of 880 cases with acute leukemia and analyzed their age difference in relation to the morphological subtype and the karyotype. We divided the patients into 3 age groups: child (0-15 years), adult (16-59 years) and elderly (60 years and older) group. The diagnoses based on the French-American-British (FAB) criteria and the immunophenotype as follows: 453 patients as acute myeloid leukemia (AML), 366 as precursor B-cell acute lymphoblastic leukemia (ALL) (24 CD10-cases and 342 CD10+ cases), 10 B-cell ALL and 51 T-cell ALL. In AML, there were no significant age differences in the frequency of FAB subtypes. Karyotypically, the frequencies of t(8;21) and 11q23 decreased with age and that of 5/7/8 abnormality increased with age. As for the immunophenotype in each FAB subtype, CD11b in M2 (0%) and CD34 in M3 (0%) were less commonly expressed in the child group than in the other age groups. Whereas Both CD11b (100%) and CD34 (60%) in M4 were more predominantly expressed in the child group than in the other age groups. Lymphoid antigen, CD19 showed a higher frequency (38.5%) in the child M2 than did other age M2 groups, reflecting the distribution pattern of t(8;21) among the 3 age groups. Additionally, the child group more frequently expressed this antigen (33.3%) than the older groups among CD7+ AML. In ALL, the frequency of CD10+ precursor B ALL was more common in the child group (84%) than in the adult group. On the other hand, B-cell ALL showed a lower frequency (0.7%) in the child group and T-cell ALL did a higher frequency (18.3%) in the adult group than any other age groups, respectively. Although the frequency of t(9;22) increased with age in CD10+ precursor-B ALL, myeloid antigen (CD13/CD33) expression evenly distributed among the 3 age groups. Our results suggest that phenotypic heterogeneity gradually emerged with age irrespective of the pattern of karyotype.

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Section: Resultssupporting

confidence: 81%

“…With regard to morphological FAB Number of positive case/number of cases examined (%), *1;p<.01 [16,17] . Our results show that there were no statistically significant differences in the frequencies of FAB subtypes among the patient age groups, though the most frequent FAB subtype was different in each age group.…”

Section: Resultsmentioning

confidence: 99%

Age Difference in Immunophenotype of Acute Leukemia

Nakase¹,

Sartor²,

Bradstock³

2006

American J. of Immunology

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“…Another example of regional nonrandomness is the high incidence of t(7;ll) in ANLL patients from Japan (Sato et al, 1987). That the ethnic background might influence the karyology of tumors was first suggested by Bernstein et al (1982Bernstein et al ( , 1984, and evidence pointing in the same direction was presented by the Fourth International Workshop on Chromosomes in Leukemia, 1982Leukemia, (1984. T h e proportion of clonal abnormalities and the frequencies of t(8;21), t(15;17), and der(l1q) in ANLL were higher in blacks and orientals than in whites.…”

Section: Discussionmentioning

confidence: 99%

Geographic heterogeneity of neoplasia‐associated chromosome aberrations

Johansson

Mertens

Mitelman

1991

Genes Chromosomes & Cancer

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Using a database comprising 13,266 cytogenetically abnormal neoplasms, the geographic heterogeneity of neoplasia-associated chromosomal abnormalities was investigated by comparing the frequencies of characteristic aberrations in consecutive series of patients with the same diagnosis. Significant frequency differences between geographic areas were found for the aberrations +8, i(17q), +19, and an additional Ph1 chromosome in chronic myeloid leukemia (CML); -5, 5q-, and +8 in acute nonlymphocytic leukemia (ANLL); t(8;21) in ANLL-M2; t(15;17) in ANLL-M3; 5q- and -7 in myelodysplastic syndromes (MDS); t(9;22) and +21 in acute lymphocytic leukemia (ALL); t(14;18) in follicular lymphoma; -8 and -22/22q- in meningioma; and structural abnormalities of 12q in pleomorphic adenoma of the salivary glands (PAS). No geographic incidence variation was detected for -7 and +21 in ANLL; +8 in MDS; 6q- and +8 in ALL; +12 in chronic lymphocytic leukemia; 6q- in non-Hodgkin's lymphoma (NHL); t(8;14) in Burkitt's lymphoma; t(11;22) in Ewing's sarcoma; i(12p) in germ cell tumors; 1p- in neuroblastoma; structural abnormalities of 3q, 8q, and 9p in PAS; or 3p- in renal cell carcinoma. Intraregional frequency similarities between cytogenetically identical abnormalities in related tumor types were also analyzed. No significant correlations were found regarding the incidence of 5q- in ANLL and MDS, 6q- in ALL and NHL, -7 in ANLL and MDS, +8 in ANLL and CML, +8 in ANLL and MDS, +8 in ALL and ANLL, or +21 in ALL and ANLL. The findings indicate that some geographic heterogeneity of tumor-associated aberrations exists both in hematologic neoplasms and in solid tumors.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…We report three cases with complex translocations, all of which involve both chromosomes 15 and 17 and demonstrate the expected RARA and PML gene rearrangements. Variant translocations have been reported previously in APL and fall into two categories: simple translocations, in which chromosome 17 or 15 is involved in a reciprocal translocation with a single aberrant chromosome; and complex translocations in which three or more chromosomes are involved (Bernstein et al, 1980(Bernstein et al, , 1982Callen et al, 1985;Berger et al, 1987Berger et al, , 1991Bjerrum et al, 1987;Heim et al, 1988;Osella et a]., 1991). Two of our cases demonstrated threeway translocations involving chromosome 3; however, the breakpoints in the two cases occurred in different areas of the short arm of chromosome 3.…”

Section: Gene Rearrangement Studiesmentioning

confidence: 99%

RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features

McKinney

Williams

Golden

et al. 1994

Genes Chromosomes & Cancer

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The translocation t(15;17) associated with acute promyelocytic leukemia (APL) results in fusion of the retinoic acid receptor alpha (RARA) gene on chromosome 17 with the putative transcription factor gene, PML, on chromosome 15. We report three cases of APL with complex cytogenetic translocations and five cases with atypical phenotypic features with rearrangements within or adjacent to the second intron of the RARA gene. Two patients demonstrated three-way translocations involving chromosomes 3, 15, and 17, but with differing breakpoints on the short arm of chromosome 3. A third patient developed a complex karyotype at the time of third relapse, but with no change in RARA and PML gene rearrangement pattern. Three patients had normal karyotypes; however, only small numbers of cells could be analyzed. One patient's leukemic cells expressed the T-cell-associated antigen CD2 and revealed T-cell receptor beta and gamma gene rearrangements. The localization of breakpoints to the second intron of the RARA gene in cytogenetically and phenotypically atypical cases provides additional support for a requisite role of the PML/RARA fusion gene in the pathogenesis of APL.

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Karyotype analysis in acute nonlymphocytic leukemia (ANLL): Comparison with ethnic group, age, morphology, and survival

Cited by 44 publications

References 21 publications

Age Difference in Immunophenotype of Acute Leukemia

Age Difference in Immunophenotype of Acute Leukemia

Geographic heterogeneity of neoplasia‐associated chromosome aberrations

RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features

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