KARYOTYPIC CONVERSION IN Ph1-POSITIVE CHRONIC MYELOID LEUKÆMIA WITH COMBINATION CHEMOTHERAPY

Sharp, J. C.; Joyner, Miles V.; Wayne, A. W.; Kemp, John D.; Crofts, M; Birch, AA; McArthur, Grant A.; Lai, Shih‐Wei; Sterndale, H.; Williams, Yvonne

doi:10.1016/s0140-6736(79)92008-7

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Rationale For Autografting In CML1

Chronic Granulocytic Leukaemia1

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1981

2006

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Cited by 54 publications

(2 citation statements)

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“…Clinically, this observation has been confirmed after treatment with IFN-α [3][4][5][6][7], intensive chemotherapy [8][9][10][11], and mobilization of Ph-negative progenitor cells into the peripheral blood after intensive chemotherapy [12][13][14][15]. Cytogenetic and other clonality studies suggest but do not prove that these cells are part of the original "normal" population [16][17][18][19][20].…”

Section: Rationale For Autografting In CMLmentioning

confidence: 99%

Autotransplants in Chronic Myeloid Leukemia

Carella

1998

The Oncologist

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Section: Rationale For Autografting In CMLmentioning

confidence: 99%

Autotransplants in Chronic Myeloid Leukemia

Carella

1998

The Oncologist

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“…Hydroxyurea may be useful in the accelerated phase before overt transformation, where busulphan or melphalan may no longer be effective. More intensive chemotherapy has been used but although karyotypic conversions have been obtained in some cases the overall survival has not been significantly improved (Sharp et al, 1979). Neither does early elective splenectomy delay the onset of metamorphosis (Ihde et al, 1976) although it may make the terminal phase easier to manage.…”

Section: Chronic Granulocytic Leukaemiamentioning

confidence: 99%

Recent advances in haematology

Samson

Chanarin

Reid

1981

Postgraduate Medical Journal

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Results of a prospective randomized trial of early splenectomy in chronic myeloid leukemia. The italian cooperative study group on chronic myeloid leukemia

Baccarani

1984

Cancer

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The role of early splenectomy in the management of chronic myeloid leukemia (CML) was investigated in a multicentric study with 21 contributing Hospitals. One hundred eighty‐nine patients younger than 66 years of age and previously untreated, were first seen between November 1974 and May 1977, were randomized to splenectomy or to nonsplenectomy, were given the same chemotherapy (busulfan, and courses of arabinosyl cytosine, 6‐thioguanine, and daunomycin), and were followed up for more than 5 years. Median survival was 45 months. No relationship of splenectomy to survival length could be shown either in the whole series, or in several subgroups that were selected according to presentation features and stage classification. Thromboembolic and vascular accidents were more frequent in the splenectomy group, and this was associated with more difficult control of platelet count. Early splenectomy is not recommended for treatment of CML.

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KARYOTYPIC CONVERSION IN Ph1-POSITIVE CHRONIC MYELOID LEUKÆMIA WITH COMBINATION CHEMOTHERAPY

Cited by 54 publications

References 7 publications

Autotransplants in Chronic Myeloid Leukemia

Autotransplants in Chronic Myeloid Leukemia

Recent advances in haematology

Results of a prospective randomized trial of early splenectomy in chronic myeloid leukemia. The italian cooperative study group on chronic myeloid leukemia

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