Kashin-Beck disease and iodine deficiency in Tibet

Moreno‐Reyes, Rodrigo; Suetens, Carl; Mathieu, Françoise; Begaux, Françoise; Zhu, Dan; Rivera, T.; Boelaert, Marleen; Nève, Jean; Perlmutter, Noémi; Vanderpas, Jean

doi:10.1007/s002640000216

Cited by 33 publications

(34 citation statements)

References 10 publications

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“…A significant prevalence of goitre exists in Tibet. An appropriate dietary programme of iodine and selenium supplements should be encouraged [11,12,16]. The bilateral nature of the symptoms seen in 79% of the cases on a clinical basis [9,10] is even more evident on radiological examination where 99.4% of the lesions are bilateral.…”

Section: Discussionmentioning

confidence: 99%

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The anatomical distribution of radiological abnormalities in Kashin-Beck disease in Tibet

Hinsenkamp

Ryppens

Begaux

et al. 2001

International Orthopaedics (SICOT)

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A radiological study of osteoarticular changes in Kashin-Beck Disease (KBD) was undertaken on the appendicular skeleton in 105 patients with KBD, in 31 healthy subjects living in an endemic area and in 30 healthy subjects living in a non-endemic area. The bone age was delayed in all three populations with no significant difference between the three studied Tibetan populations. Radiological changes occur in 56% of patients with KBD, and are usually bilateral. An analysis of the distribution of lesions shows a proximo-distal gradient. The changes are more common in the distal aspect of the limb and the lower limb is involved more commonly than the upper limb. The foot and ankle are involved in 89.5% of cases. The radiological changes and their distribution might be explained by the hypothesis of inhibition of angiogenesis by mycotoxins, exacerbated by chemical and physical environmental factors.Résumé Une étude radiographique des lésions ostéoarti-culaires produites par la maladie de Kashin-Beck (KBD) a été réalisée au Tibet sur le squelette appendiculaire de 105 patients atteints de KBD, de 31 sujets cliniquement sains vivant en région endémique et de 30 sujets en ré-gion non endémique. La détermination de l'âge osseux révèle un retard de la maturité osseuse dans les trois groupes. Les lésions radiologiques sont présentes dans 56% des cas cliniques de KBD et sont bilatérales dans presque tous les cas. Le nombre de lésions augmente vers la périphérie. Le membre inférieur est plus souvent atteint que le membre supérieur. Le pied et la cheville sont atteints dans 89.5% des cas présentant une lésion radiologique. Les lésions radiologiques observées et leur distribution pourraient être expliquées par une inhibition de l'angiogénèse aggravée par les facteurs environnementaux chimiques et physiques.

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Section: Discussionmentioning

confidence: 99%

“…This sum gives a scale from 0 to 36. This scale is divided into four stages: stage 0, I (1-10), II (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and III (21-36). The bilateral presence of radiological signs was tested for each variable with the κ-test.…”

Section: Methodsmentioning

confidence: 99%

The anatomical distribution of radiological abnormalities in Kashin-Beck disease in Tibet

Hinsenkamp

Ryppens

Begaux

et al. 2001

International Orthopaedics (SICOT)

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“…However, no favorable effects have been reported for progression of clinical conditions in HIV-infected patients [82], neonatal outcomes in very low birth weights infants [83], adult asthma [84], thyroid function in pregnant women from a mild-to-moderate iodine-deficient population [85] and Hashimoto thyroidits [86], postnatal depression [87], and rheumatoid arthritis [88]. On the contrary, weak indications of positive effects of Se have been given by a randomized trial on critically ill patients [89] and a trial for the prevention of an osteoarthropathy named Kashin-Beck disease [90,91], the association of which with Se status is uncertain [92]. Beneficial effect of Se has been noted for disease progression in the case of patients with mild Graves' orbitopathy [93], pre-eclampsia and pregnancy-induced hypertension [94], and for some outcomes of patients critically ill, specifically, with septic syndrome [95,96].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

140

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In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and laboratory Downloaded by [New York University] at 16:24 19 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2studies, however, are changing our perception of the biological effects of this nutritionally essential trace element. We reviewed the most recent epidemiologic and biochemical literature on selenium, synthesizing the findings from these studies into a unifying view. Randomized trials have shown that selenium did not protect against cancer and other chronic diseases, but even increased the risk of specific neoplasms such as advanced prostate cancer and skin cancer, in addition to type 2 diabetes. Biochemical studies indicate that selenium may exert a broad pattern of toxic effects at unexpectedly low concentrations. Furthermore, its upregulation of antioxidant proteins (selenium-dependent and selenium-independent) may be a manifestation of self-induced oxidative stress. In conclusion, toxic effects of selenium species occur at lower concentrations than previously believed. Those effects may include a large range of proteomic changes and adverse health effects in humans. Since the effects of environmental exposure to this element on human health still remain partially unknown, but are potentially serious, the toxicity of selenium exposure should be further investigated and considered as a public health priority.

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“…Selenium deficiency in humans can therefore interact critically in I metabolism, leading to an I-unresponsive condition or, even worse, a negative response to I (Hotz et al, 1997). Some recent reports have suggested that Kashin-Beck disease might also be related to I deficiencies as well as Se deficiency (Moreno-Reyes et al, 2001;Zhang et al, 2001). Given the fact that in many parts of China Se and I deficiencies occur together (Tan, 1989), it is necessary to consider a possible dual supplementation of the two elements in the diet.…”

Section: Introductionmentioning

confidence: 99%

Interactions between selenium and iodine uptake by spinach (Spinacia oleracea L.) in solution culture

Zhu¹,

Huang²,

Hu³

et al. 2004

Plant and Soil

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Interactions between Se (as selenate) and I (as iodate) uptake by spinach plants (Spinacia oleracea L.) were studied under controlled conditions using solution culture. Spinach readily accumulated both Se and I in the edible parts, the leaves, with solution-to-leaf transfer factors ranging from 3.5 to 13.4. The distribution coefficients between leaves and roots ranged from 4.07 to 5.66 for I and 4.51 to 8.59 for Se. Selenium concentrations in plant tissues were unaffected by addition of I to the nutrient solution. Similarly, plant I concentrations were unaffected by addition of Se to the nutrient solution, except in nutrient solution with I at a concentration of 50 µM, in which addition of Se lowered shoot I concentrations significantly, but the effect was of low magnitude. These results indicate the possible feasibility of dual supplementation of plant growth substrates with Se and I to improve human nutrition where these two elements are deficient in the diet. The data also indicate the involvement of a positive feedback mechanism in the uptake of Se by spinach plants, since Se concentrations in leaves increased disproportionately with increasing Se concentration in the nutrient solution.

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Kashin-Beck disease and iodine deficiency in Tibet

Cited by 33 publications

References 10 publications

The anatomical distribution of radiological abnormalities in Kashin-Beck disease in Tibet

The anatomical distribution of radiological abnormalities in Kashin-Beck disease in Tibet

Selenium and Human Health: Witnessing a Copernican Revolution?

Interactions between selenium and iodine uptake by spinach (Spinacia oleracea L.) in solution culture

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