KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease

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doi:10.3350/cmh.2013.19.4.325

Cited by 107 publications

(59 citation statements)

References 225 publications

(248 reference statements)

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“…Nonalcoholic fatty liver disease (NAFLD), a common cause of chronic liver disease, with an increasing prevalence (20%–30%) worldwide, 10 , 11 is the most common cause of elevated serum ALT levels. 10 An association between hepatic fat and VAT has been suggested, 12 and hepatic steatosis, as measured by proton magnetic resonance spectroscopy, was found to be closely related to central obesity.…”

Section: Introductionmentioning

confidence: 99%

Visceral Adipose Tissue Area as an Independent Risk Factor for Elevated Liver Enzyme in Nonalcoholic Fatty Liver Disease

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Visceral Adipose Tissue Area as an Independent Risk Factor for Elevated Liver Enzyme in Nonalcoholic Fatty Liver Disease

et al. 2015

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“…US can introduce false-negative results when fatty infiltration is below 30% [ 40 ]. However, it was impossible to perform an invasive test in an apparently healthy population, and US is used as the first-line method for clinical practical guidelines [ 41 , 42 ]. Third, information on dietary components and tests for inflammation were unavailable.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Metabolic Factors for Nonalcoholic Fatty Liver Disease in Women

Chung

Yim

Kim

et al. 2015

BioMed Research International

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Background/Aims. Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD). However, the pathogenesis of NAFLD in women has not been clearly defined. In this study, we aimed to determine the risk factors for NAFLD in women. Methods. A retrospective cohort study was conducted. Women who underwent abdominal ultrasonography and blood sampling for routine health check-ups were recruited. Results. Among 1,423 subjects, 695 women (48.9%) were in a menopausal state. The prevalence of NAFLD was higher in postmenopausal women than in premenopausal women (27.2% versus 14.4%, P < 0.001). In premenopausal women, low HDL-cholesterol, central obesity, and homeostasis model assessment-estimated insulin resistance showed a significant association with the increased risk of NAFLD in multivariate analysis. In postmenopausal women, the presence of diabetes, triglyceridemia, and central obesity showed a significant association with the risk of NAFLD. The presence of menopause and hormone replacement therapy in postmenopausal women were not risk factors for NAFLD. Conclusions. Our findings showed different metabolic factors for NAFLD in pre- and postmenopausal women. However, the key issues are the same: central obesity and insulin resistance. These results reemphasize the importance of metabolic factors irrespective of menopausal status in the pathogenesis of NAFLD in women.

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“…NAFLD is the most common chronic liver disease and its prevalence has increased to 20–30% in Western nations and to 16–33% in Korea [7, 8], and it leads to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma in some individuals [9]. NAFLD is closely associated with risk factors for cardiovascular diseases, including central obesity, dyslipidemia, hypertension, and glucose intolerance, all of which are components of metabolic syndrome [10].…”

Section: Introductionmentioning

confidence: 99%

Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease

Chung

Yim

Kim

et al. 2016

Gastroenterology Research and Practice

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Aims. Chronic low-grade inflammation is thought to be associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the association between serum white blood cell (WBC) counts and the development of incidental NAFLD. Methods. In this retrospective longitudinal cohort study, we recruited participants who underwent abdominal ultrasonography and blood samplings during medical checkups in both 2005 and 2010. A total of 2,216 subjects were included in our analyses. Results. The prevalence of NAFLD in 2010 increased steadily in conjunction with increasing WBC counts in 2005 after adjustment for body mass index (BMI) [odds ratio (OR) 2.44, 95% confidence interval (CI) = 1.49–4.00 for women and OR 2.42, 95% CI = 1.61–3.63 for men, lowest quartile versus highest quartile]. Multivariate regression analysis after adjusting for age, BMI, hypertension, smoking, triglycerides, HDL cholesterol, and glucose levels revealed that NAFLD was significantly associated with the highest WBC quartile compared to the lowest quartile [OR 1.85, 95% CI, 1.10−3.10 for women and OR 1.68, 95% CI, 1.08−2.61 for men]. Conclusions. We demonstrated that the risk of developing NAFLD was significantly associated with WBC counts independently of metabolic factors. This finding provides novel evidence indicating that serum WBC counts may be potential surrogate markers of NAFLD.

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KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease

Cited by 107 publications

References 225 publications

Visceral Adipose Tissue Area as an Independent Risk Factor for Elevated Liver Enzyme in Nonalcoholic Fatty Liver Disease

Visceral Adipose Tissue Area as an Independent Risk Factor for Elevated Liver Enzyme in Nonalcoholic Fatty Liver Disease

The Influence of Metabolic Factors for Nonalcoholic Fatty Liver Disease in Women

Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease

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