KAT6A::EP300 fusion in congenital myeloid sarcoma: Yet another novel molecular marker indicating spontaneous remission?

Abstract

KAT6A, a histone/lysine acetyltransferase is located on 8p11 and has been reported in association with a variety of partner genes like CREBBP (16p13), EP300 (22q13), LEUTX (9q13), NCOA2, NCOA3, and ASXL2. Favorable prognosis and spontaneous remission in congenital AML with t (8; 16) translocation have been reported. More recently, a single case report with spontaneous remission in congenital AML with KAT6A and another partner gene EP300 t (8; 22) has been described. Here we report an additional patient with congenital myeloid sarcoma of the skin with t (8; 22) with spontaneous remission.