Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer

Abstract

Background: This study aimed to assess the correlation of katanin P60 expression with clinical characteristics and survival profiles of surgical non-small cell lung cancer (NSCLC) patients. Methods: Two hundred and sixty-five primary NSCLC patients treated by surgical resection were retrospectively viewed. The expression of katanin P60 in the tumor specimen was detected by the immunohistochemical (IHC) staining assay. Preoperative clinical data were collected from patients' medical records, and survival data were extracted from follow-up records. Results: There were 127 (47.9%) and 138 (52.1%) patients with katanin P60-low expression and-high expression, respectively; in addition, patients presenting katanin P60-high+,-high++, and-high+++ expression were 62 (23.4%), 63 (23.8%), and 13 (4.9%), respectively. Katanin P60 expression was correlated with lymph node (LYN) metastasis and advanced TNM stage but not pathological grade, tumor size, carcinoembryonic antigen (CEA) level or other non-tumor features in NSCLC patients. Regarding survival profiles, disease-free survival (DFS) and overall survival (OS) were both the lowest in katanin P60-high+++ expression patients, followed with katanin P60-high++ patients, katanin P60-high+ patients, and the highest in katanin P60-low expression patients. Further analysis illustrated that katanin P60-high expression was an independent predictive factor for unfavorable DFS and OS in NSCLC patients. Conclusions: Katanin P60 presents potential as a biomarker for lymph node metastasis and prognosis in NSCLC patients.

Katanin subunits p60 and p80, potential biomarkers for papillary thyroid carcinoma to distinguish nodular goiter: STROBE

“…Both katanin p60 and p80 expression were also significantly correlated with higher lymph node metastasis and shorter overall survival in patients with breast cancer [22,23] . Recently, similar roles of katanin p60 and p80 have also been reported in NSCLC [25,26] . These results clearly show that katanin subunits p60 and p80 are not only highly expressed in cancer tissues, but also play a role in the proliferation, migration, and metastasis of cancer cells, and are related to the prognosis of cancer patients.…”

“…Elevated expression of katanin p60 has been shown during prostate cancer progression and may contribute to cancer metastasis [21] . Similarly, both katanin subunits p60 and p80 have been found to be correlated with lymph node metastasis and worse prognosis in breast cancer [22–24] and non-small cell lung cancer (NSCLC) [25,26] . In particular, it has recently been reported that compared with adjacent PTC tissues, both are highly expressed in tumor tissues [27] .…”

Ring finger protein 180 suppresses cell proliferation and energy metabolism of non-small cell lung cancer through downregulating C-myc

“…However, the moleculer pathogenesis still need to be further explored. It has been identified that Katanin P60 is a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer [ 26 ]. Moreover, circular RNAs are reported to play an essential role in the progression of human lung cancer [ 27 ].…”

The Mammalian Family of Katanin Microtubule-Severing Enzymes

“…The elevated expression of KATNB1 shares a similar positive correlation with advanced breast cancer staging, lymph node metastasis, and reduced rates of overall survival in patients ( Table 1 ; Li et al, 2018 ). Additionally, in non-small cell lung cancer (NSCLC), the elevated expression of KATNA1 and KATNB1 correlates with lymph node metastasis and advanced tumor progression ( Table 1 ; Wang et al, 2020 ; Ye et al, 2020 ). Katanin expression is also dysregulated in other types of cancers like papillary thyroid carcinoma (PTC), where both KATNA1 and KATNB1 are highly expressed in tumors and tumor-adjacent tissues; furthermore, elevated katanin expression correlates with advanced PTC staging and worse disease-free survival in patients ( Chen et al, 2020 ).…”

“…Katanins function by harnessing the energy produced from ATP hydrolysis to drive microtubule-severing events ( McNally and Vale, 1993 ; McNally and Thomas, 1998 ). Due to their role in facilitating cytoskeletal rearrangements, the katanins have become the subject of intense research in the fields of neuroscience ( Banks et al, 2018 ), cancer ( Wang et al, 2020 ), and cell and structural biology ( Willsey et al, 2018 ; Faltova et al, 2019 ; Korulu and Yildiz, 2020 ).…”